Pharmaceuticals, policy and law
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#1Theodoros Mavridis (UoA: National and Kapodistrian University of Athens)H-Index: 4
Last. Dimos D. Mitsikostas (UoA: National and Kapodistrian University of Athens)H-Index: 31
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Now more than ever is the time of monoclonal antibody use in neurology. In headaches, disease-specific and mechanism-based treatments existed only for symptomatic management of migraines (i.e., triptans), while the standard prophylactic anti-migraine treatments consist of non-specific and repurposed drugs that share limited safety profiles and high risk for interactions with other medications, resulting in rundown adherence rates. Recent advances in headache science have increased our understand...
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#1Fakhara Sabir (University of Szeged)H-Index: 6
#2Gábor Katona (University of Szeged)H-Index: 8
Last. Ildikó Csóka (University of Szeged)H-Index: 13
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The objective of the present study was to develop n-propyl gallate-loaded solid lipid nanoparticles (PG-SLNs) in a hydrogel (HG) formulation using Transcutol-P (TC-P) as a permeation enhancer. Modified solvent injection technique was applied to produce optimized PG-SLNs via the Quality by Design approach and central composite design. The in vitro mucoadhesion, scavenging activity, drug release, permeation studies of PG from PG-SLNs-loaded HG were evaluated under simulated nasal conditions. Compa...
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#1Gwenolé Loas (ULB: Université libre de Bruxelles)H-Index: 15
#2Pascal Le Corre (University of Rennes)H-Index: 27
The SARS-CoV-2 outbreak is characterized by the need of the search for curative drugs for treatment. In this paper, we present an update of knowledge about the interest of the functional inhibitors of acid sphingomyelinase (FIASMAs) in SARS-CoV-2 infection. Forty-nine FIASMAs have been suggested in the treatment of SARS-CoV-2 infection using in silico, in vitro or in vivo studies. Further studies using large-sized, randomized and double-blinded controlled clinical trials are needed to evaluate F...
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#1Ana C. Gonçalves (UBI: University of Beira Interior)H-Index: 6
#2Ana R. Nunes (UBI: University of Beira Interior)H-Index: 3
Last. Luís R. Silva (UBI: University of Beira Interior)H-Index: 23
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In recent years, the consumption of natural-based foods, including beans, fruits, legumes, nuts, oils, vegetables, spices, and whole grains, has been encouraged. This fact is essentially due to their content in bioactive phytochemicals, with the phenolic compounds standing out. Among them, anthocyanins have been a target of many studies due to the presence of catechol, pyrogallol, and methoxy groups in their chemical structure, which confer notable scavenging, anti-apoptotic, and anti-inflammato...
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#1Maria Narożna (Poznan University of Medical Sciences)H-Index: 2
#2Violetta Krajka-Kuźniak (Poznan University of Medical Sciences)H-Index: 18
Last. Wanda Baer-Dubowska (Poznan University of Medical Sciences)H-Index: 30
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Combining NSAIDs with conventional therapeutics was recently explored as a new strategy in cancer therapy. Our earlier studies showed that novel oleanolic acid oximes (OAO) conjugated with aspirin or indomethacin may enhance their anti-cancer potential through modulation of the Nrf2 and NF-κB signaling pathways. This study focused on the synthesis and biological evaluation of four diclofenac (DCL)-OAO derivative conjugates in the context of these pathways' modification and hepatic cells survival...
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#1Galina N. SinginaH-Index: 1
Last. I. LebedevaH-Index: 4
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Aging processes accelerate dramatically in oocytes that have reached the metaphase-II (M-II) stage. The present work aimed to study the patterns and intracellular pathways of actions of prolactin (PRL) and growth hormone (GH) on age-associated changes in bovine M-II oocytes aging in vitro. To this end, we analyzed spontaneous parthenogenetic activation (cytogenetic assay), apoptosis (TUNEL assay), and the developmental capacity (IVF/IVC) of in vitro-matured oocytes after prolonged culturing. Bot...
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#1Mashiro Okunaka (Meiji Pharmaceutical University)H-Index: 1
#2Daisuke KanoH-Index: 4
Last. Yoshihiro Uesawa (Meiji Pharmaceutical University)H-Index: 14
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Chemotherapy-induced neutropenia (CIN) has been associated with a risk of infections and chemotherapy dose reductions and delays. The chemotherapy regimen remains one of the primary determinants of the risk of neutropenia, with some regimens being more myelotoxic than others. Although a number of clinical trials have currently highlighted the risk of CIN with each chemotherapy regimen, only a few ones have comprehensively examined the risk associated with all chemotherapeutic agents. Therefore, ...
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#1Ravichandran Veerasamy (Saveetha University)H-Index: 1
Last. Harish RajakH-Index: 18
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A significant number of the anti-inflammatory drugs currently in use are becoming obsolete. These are exceptionally hazardous for long-term use because of their possible unfavourable impacts. Subsequently, in the ebb-and-flow decade, analysts and researchers are engaged in developing new anti-inflammatory drugs, and many such agents are in the later phases of clinical trials. Molecules with heterocyclic nuclei are similar to various natural antecedents, thus acquiring immense consideration from ...
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#1Juthamart ManeenetH-Index: 2
Last. Yaowared ChulikhitH-Index: 5
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Major depressive disorder (MDD) is a common and debilitating psychiatric disease characterized by persistent low mood, lack of energy, hypoactivity, anhedonia, decreased libido, and impaired cognitive and social functions. However, the multifactorial etiology of MDD remains largely unknown due the complex interaction between genetics and environment involved. Kleeb Bua Daeng (KBD) is a Thai traditional herbal formula that has been used to promote brain health. It consists of a 1:1:1 ratio of the...
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#1Flavia VaranoH-Index: 28
#2Daniela CatarziH-Index: 28
Last. Rosaria VolpiniH-Index: 33
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New compounds with a 7-amino-2-arylmethyl-thiazolo[5,4-d]pyrimidine structure were synthesized and evaluated in vitro for their affinity and/or potency at the human (h) A1, hA2A, hA2B, and hA3 adenosine receptors (ARs). Several compounds (5, 8–10, 13, 18, 19) were characterized by nanomolar and subnanomolar binding affinities for the hA1 and the hA2A AR, respectively. Results of molecular docking studies supported the in vitro results. The 2-(2-fluorobenzyl)-5-(furan-2yl)-thiazolo[5,4-d]pyrimidi...
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