Tissue Engineering and Regenerative Medicine
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#1Felipe Allan da Silva da Costa (UNESP: Sao Paulo State University)
#2Murilo Racy Soares (USP: University of São Paulo)H-Index: 1
Last. João Tadeu Ribeiro-Paes (UNESP: Sao Paulo State University)H-Index: 17
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BACKGROUND Chronic respiratory diseases (CRD) are a major public health problem worldwide. In the current epidemiological context, CRD have received much interest when considering their correlation with greater susceptibility to SARS-Cov-2 and severe disease (COVID-19). Increasingly more studies have investigated pathophysiological interactions between CRD and COVID-19. AREA COVERED Animal experimentation has decisively contributed to advancing our knowledge of CRD. Considering the increase in e...
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#1Dong Jun Park (UCSD: University of California, San Diego)H-Index: 1
#2Young Joon Seo (Yonsei University)H-Index: 13
In the field of tissue regeneration and tissue engineering, many years ago, various nano to macroscopic-sized materials have been used to reduce inflammation and restore damaged tissue. Whether it is safe to study the regeneration of all tissues based on the biological mechanisms of an organism composed of cells is still debated, and studies using extracellular vesicles derived from cells have become popular in the past decade. It has been reported that exosomes with a size of 100 nm or less, wh...
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BACKGROUND In order to produce and isolate the exosome derived from the cell of interests, a serum free environment (starvation) has been essential for excluding the unknown effect from serum-derived exosomes. Recently, serum-free culture media have been developed as a substitute for serum supplemented media so that MSC proliferates with maintaining the original characteristics of the cells in a serum free condition. Due to the different properties of the exosomes representing the states and cha...
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#1Vyshnavi Tallapaneni (Jagadguru Sri Shivarathreeswara University)H-Index: 1
#2Kalaivani C (Jagadguru Sri Shivarathreeswara University)
Last. Veera Venkata Satyanarayana Reddy Karri (Jagadguru Sri Shivarathreeswara University)H-Index: 10
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Diabetic wound (DW) is one of the leading complications of patients having a long history of uncontrolled diabetes. Moreover, it also imposes an economic burden on people suffering from wounds to manage the treatment. The major impending factors in the treatment of DW are infection, prolonged inflammation and decreased oxygen levels. Since these non-healing wounds are associated with an extended recovery period, the existing therapies provide treatment for a limited period only. The areas covere...
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#1Mohd Yazid Bajuri (UKM: National University of Malaysia)H-Index: 6
#2Nanchappan Selvanathan (UKM: National University of Malaysia)
Last. Angela Min Hwei Ng (UKM: National University of Malaysia)
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BACKGROUND Managing massive bone defects, a great challenge to orthopaedics reconstructive surgery. The problem arise is the supply of suitable bone is limited with many complications. Tissue-engineered hydroxyapatite bone (TEHB) scaffold impregnated with osteoprogenitor cells developed as an alternative to promote bone regeneration. METHODS This animal protocol has been approved by Universiti Kebangsaan Malaysia Animal Ethical Committee. The TEHB scaffold prepared from hydroxyapatite using gel ...
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#1Panagiotis Mallis (Academy of Athens)H-Index: 9
#2Charalampos Oikonomidis (Academy of Athens)
Last. Michalis Katsimpoulas (Academy of Athens)H-Index: 8
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BACKGROUND Renal dysfunction remains a global issue, with chronic kidney disease being the 18th most leading cause of death, worldwide. The increased demands in kidney transplants, led the scientific society to seek alternative strategies, utilizing mostly the tissue engineering approaches. Unlike to perfusion decellularization of kidneys, we proposed alternative decellularization strategies to obtain acellular kidney scaffolds. The aim of this study was the evaluation of two different decellula...
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#1Jae Young Park (Seoul National University Hospital)H-Index: 15
#2Hyun Cheol Bae (Seoul National University Hospital)H-Index: 2
Last. Hyuk Soo Han (Seoul National University Hospital)H-Index: 15
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BACKGROUND Transforming growth factor beta 1 (TGFβ1) plays an essential role in maintaining cartilage homeostasis. TGFβ1 is known to upregulate anabolic processes in articular cartilage, but the role of TGFβ1 in chondrocyte catabolism remains unclear. Thus, we examined whether TGFβ1 increases catabolic processes in the osteoarthritic joint via transglutaminase 2 (TG2). In this study, we investigated whether interplay between TGFβ1 and TG2 mediates chondrocyte catabolism and cartilage degeneratio...
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#1Seokhyeong Go (SNU: Seoul National University)H-Index: 3
#2Mikyung Kang (SNU: Seoul National University)H-Index: 6
Last. Byung Soo Kim (SNU: Seoul National University)H-Index: 87
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BACKGROUND Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often resistant to ferroptosis via increased ferritin and impaired ferritinophagy. In this study, we investigated whether treatment with JQ1 could remove senescent cells by inducing ferroptosis. METHODS Senescence of human dermal fibroblasts was ...
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#1Zhang ShuxinH-Index: 1
Last. Eui-Seok Lee (KU: Korea University)H-Index: 7
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Autogenous odontogenic materials are a new, highly biocompatible option for jaw restoration. The inorganic component of autogenous teeth acts as a scaffold to maintain the volume and enable donor cell attachment and proliferation; the organic component contains various growth factors that promote bone reconstruction and repair. The composition of dentin is similar to that of bone, which can be a rationale for promoting bone reconstruction. Recent advances have been made in the field of autogenou...
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#1Thi-Tuong Van Nguyen (Ho Chi Minh City University of Science)
#1Thi-Tuong Van Nguyen (Ho Chi Minh City University of Science)
Last. Phuc Van Pham (Ho Chi Minh City University of Science)H-Index: 16
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Ischemic diseases are conditions associated with the restriction or blockage of blood supply to specific tissues. These conditions can cause moderate to severe complications in patients, and can lead to permanent disabilities. Since they are blood vessel-related diseases, ischemic diseases are usually treated with endothelial cells or endothelial progenitor cells that can regenerate new blood vessels. However, in recent years, mesenchymal stem cells (MSCs) have shown potent bioeffects on angioge...
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Top fields of study
Anatomy
Biomedical engineering
Chemistry
Mesenchymal stem cell
Stem cell
Tissue engineering
Biology
Cell biology