Minerva gastroenterologica e dietologica
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#2Amjad Khan (University of Oxford)H-Index: 4
Last. Bikha Ram Devrajani (Liaquat University of Medical and Health Sciences)H-Index: 8
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When looking for new antiviral compounds aimed to counteract the COVID-19, a disease caused by the recently identified novel coronavirus (SARS-CoV-2), the knowledge of the main viral proteins is fundamental. The major druggable targets of SARS-CoV-2 include 3-chymotrypsin-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent 26 RNA polymerase, and spike (S) protein. Molecular docking studies have highlighted that quercetin, a natural polyphenol belonging to the flavonol class, inhi...
5 CitationsSource
#2Long ShiH-Index: 1
Last. Giovanna Ferraioli (UNIPV: University of Pavia)H-Index: 32
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Elastography can be thought as an extension of the ancient technique of palpation. After giving a short introduction to the history of elastography, the different technologies that are nowadays available and the physics behind them, the article focuses on the assessment of liver stiffness in patients with diffuse liver disease using shear wave elastography (SWE). Practical advices on how to perform the SWE techniques and on the factors that should be taken into account for a correct interpretati...
2 CitationsSource
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#1Mauro Lombardo (OU: Open University)H-Index: 10
#2Chiara Bellia (University of Palermo)H-Index: 19
Last. Alfonso Bellia (OU: Open University)H-Index: 2
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BACKGROUND: Controversy exists regarding whether the different daily balances of proteins between meals and snacks in a low-calorie diet may influence the effects on body composition (BC) results. Aim of this study is to evaluate BC changes made by a lifestyle intervention in a randomised homogeneous sample of two groups with equal daily caloric reduction but different protein distributions between meals. METHODS: Forty-seven men and women (mean +/- SD age: 32 +/- 10 y; body mass index: 28.4 +/-...
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#1Mauro Giuffrè (UniTS: University of Trieste)H-Index: 10
#2Michele Campigotto (UniTS: University of Trieste)H-Index: 5
Last. Riccardo Sigon (UniTS: University of Trieste)H-Index: 1
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Introduction Alcohol-related liver disease (ALD) was estimated to have a prevalence of 2% among the United States population. Since severe fibrosis in compensated patients is the main predictor of long-term survival, it is of utmost importance to early detect patients with severe fibrosis before decompensation occurs. Liver elastography has been used to stage liver fibrosis. However, there is a widespread lack in guidelines for the correct use of liver stiffness (LS) in ALD. Evidence acquisition...
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#1Tawfik Khoury (BIU: Bar-Ilan University)H-Index: 11
#2Wisam Sbeit (BIU: Bar-Ilan University)H-Index: 6
Last. Amir MariH-Index: 6
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Liver stiffness is related to the degree of hepatic fibrosis which ultimately causes portal hypertension and gastroesophageal varices. Variceal bleeding is a worrisome and potentially fatal complication of cirrhosis, primary prophylaxis has demonstrated a reduction in decompensation and mortality. Portal hypertension and esophageal varices needing treatment could be predicted through noninvasive methods, including elastography, that evaluates the mechanical properties of liver or spleen tissue i...
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#8Francesco Paolo Russo (UNIPD: University of Padua)H-Index: 29
#9Marco Senzolo (UNIPD: University of Padua)H-Index: 38
Hepatocellular carcinoma (HCC) represents the sixth most commonly diagnosed cancer and the fourth leading cause of cancer-related death worldwide. HCC occurs predominantly in patients with underlying chronic liver disease and cirrhosis, and it presents a poor prognosis in advanced stage. Since its approval, for the following 10 years, sorafenib remained the only systemic agent with proven clinical efficacy for patients with advanced HCC. Recently, more drugs have been studied and several advance...
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