Cancer Medicine
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#2Zhenyu Liu (CAS: Chinese Academy of Sciences)H-Index: 27
Last. Tian Jie
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BACKGROUND This study evaluated the predictive value of gene signatures for biochemical recurrence (BCR) in primary prostate cancer (PCa) patients. METHODS Clinical features and gene expression profiles of PCa patients were attained from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets, which were further classified into a training set (n = 419), a validation set (n = 403). The least absolute shrinkage and selection operator Cox (LASSO-Cox) method was used to select disc...
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#1Rebecca P. Luoh (UW: University of Wisconsin-Madison)
#2Amye J. Tevaarwerk (UW: University of Wisconsin-Madison)H-Index: 20
Last. Mary E. Sesto (UW: University of Wisconsin-Madison)H-Index: 17
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BACKGROUND Portals can assist patients in managing their healthcare. Understanding how patients with cancer use portals can facilitate improvements in patient engagement in cancer care. This study sought to determine if patients with cancer used portals differently for cancer versus noncancer purposes. The effects of geographic residence (rural vs. urban residence) and cancer stage on portal usage were also investigated. METHODS We conducted a retrospective analysis of portal usage by patients s...
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#1Hajar Moradmand (Shahid Beheshti University)H-Index: 4
#2Seyed Mahmoud Reza Aghamiri (Shahid Beheshti University)H-Index: 11
Last. Hamid Emami (UI: University of Isfahan)H-Index: 1
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This retrospective study has been conducted to validate the performance of deep learning-based survival models in glioblastoma (GBM) patients alongside the Cox proportional hazards model (CoxPH) and the random survival forest (RSF). Furthermore, the effect of hyperparameters optimization methods on improving the prediction accuracy of deep learning-based survival models was investigated. Of the 305 cases, 260 GBM patients were included in our radiomics analysis based on the following criteria: d...
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#1Philip E. Castle (NIH: National Institutes of Health)H-Index: 63
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#1Till Kaemmerer (LMU: Ludwig Maximilian University of Munich)
#2Pia-Charlotte Stadler (LMU: Ludwig Maximilian University of Munich)H-Index: 1
Last. Markus Reinholz (LMU: Ludwig Maximilian University of Munich)H-Index: 16
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INTRODUCTION In this survey, we analyzed data from patients suffering from the most common cutaneous T-cell lymphomas (CTCLs) subtypes mycosis fungoides (MF) and Sezary syndrome (SS), treated with the retinoid alitretinoin during a 7-year period at our outpatient department between 2015 and 2020. MATERIALS AND METHODS We analyzed patient medical records including TNMB stage, side effects under therapy with alitretinoin, time to next treatment (TTNT), and previous photo documentation. RESULTS A t...
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#1Xuguang Chen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
#2Hanbo Chen (U of T: University of Toronto)H-Index: 1
Last. Umberto Ricardi (UNITO: University of Turin)H-Index: 52
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BACKGROUND Stereotactic body radiotherapy (SBRT) is increasingly used to treat oligometastatic disease (OMD), but the effect of metastasis timing on patient outcomes remains uncertain. METHODS An international database of patients with OMD treated with SBRT was assembled with rigorous quality assurance. Early versus late metastases were defined as those diagnosed ≤24 versus >24 months from the primary tumor. Overall survival (OS), progression-free survival (PFS), and incidences of wide-spread pr...
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#1Stéphane de Botton (Institut Gustave Roussy)H-Index: 53
#2Joseph Brandwein (U of A: University of Alberta)H-Index: 29
Last. Mathilde Hunault-BergerH-Index: 16
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BACKGROUND The present study evaluated the relative survival benefits associated with enasidenib and current standard of care (SoC) therapies for patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) and an isocitrate dehydrogenase 2 (IDH2) mutation who are ineligible for hematopoietic stem cell transplantation (HSCT). METHODS Propensity score matching (PSM) analysis compared survival outcomes observed with enasidenib 100 mg daily in the phase I/II AG221-C-001 trial and SoC outcom...
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The incidence and mortality of hepatocellular carcinoma (HCC) are gradually increasing during the past years. Recently, some studies have reported that malic enzyme (ME) plays an important role in cancer development, while the involvement of ME2 in HCC remains still undetermined. Here, we demonstrated that ME2 played an oncogenic role in HCC. ME2 was overexpressed in HCC tissues. TCGA database showed that the ME2 transcript level was inversely associated with the survival of HCC patients. Loss-o...
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#1Yu-shu Ouyang (Guangzhou University of Chinese Medicine)H-Index: 1
#2Wendao Liu (Guangzhou University of Chinese Medicine)
Last. Shunqin Long (Guangzhou University of Chinese Medicine)
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BACKGROUND The prognostic significance of programmed cell death-ligand 1 (PD-L1) expression on circulating tumor cells (CTCs) has been explored but is still in controversy. We performed, for the first time, a meta-analysis to systematically evaluate its prognostic value in human cancers. METHODS Literature databases were searched for eligible studies prior to June 30, 2021. The pooled hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated for the associations of pre-treatment...
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#1Xiangpeng Zhan (NCU: Nanchang University)
#2Ju Guo (NCU: Nanchang University)H-Index: 3
Last. Bin Fu (NCU: Nanchang University)H-Index: 15
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PURPOSE To study prognostic values of bladder neck involvement (BNI) and survival outcomes in non-muscle-invasive bladder cancer (NMIBC). METHOD AND MATERIALS The national Surveillance, Epidemiology, and End Results database (2004-2015) was applied to gain further insight into the prognostic values of BNI and 19,919 patients diagnosed with NMIBC were included in our study. We used the Kaplan-Meier method with the log-rank test and subgroup analyses to evaluate cancer-specific survival (CSS) and ...
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