Cancer Medicine
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4.45
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4,292
Papers 4,143
1 page of 415 pages (4,143 results)
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#1Guanghong Luo (SHU: Shanghai University)H-Index: 1
#2Ruili Feng (SHU: Shanghai University)H-Index: 4
Last. Tieqiao Wen (SHU: Shanghai University)H-Index: 15
view all 8 authors...
Background null Dcf1 has been demonstrated to play vital roles in many CNS diseases, it also has a destructive role on cell mitochondria in glioma cells and promotes the autophagy. Hitherto, it is unclear whether the viability of glioblastoma cells is affected by Dcf1, in particular Dcf1 possesses broad localization on different organelles, and the organelles interaction frequently implicated in cancer cells survival. null Methods null Surgically excised WHO grade IV human glioblastoma tissues w...
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#1Anne Sophie Lind Helligsoe (Aarhus University Hospital)
#2Line KenborgH-Index: 10
Last. Jeanette Falck Winther (AU: Aarhus University)H-Index: 33
view all 6 authors...
BACKGROUND Incidence rates in Denmark of central nervous system (CNS) tumors remain among the highest in the world. Survival rates, however, have improved in the past decades in high-income countries. METHODS We analyzed incidence and survival of childhood CNS tumors in Denmark diagnosed from 1997 to 2019 based on data from the Danish Childhood Cancer Registry and information on histological types, tumor localization, and treatment from medical records. RESULTS From 1997 to 2019, 949 children<15...
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#1Wang Bin (Army Medical University)
#2Chen Shu (Army Medical University)
Last. Zou Hua (Army Medical University)
view all 7 authors...
Risk factors vary in terms of the pattern of lung cancer metastasis and specific metastatic organs. In this study, we retrospectively analyzed the clinical risk factors of tumor metastasis in lung cancer patients and used second-generation gene sequencing to characterize relevant gene mutations. The risk factors of different metastatic sites of real-world lung cancer were explored to find the differentially expressed genes and risk factors in different metastatic organs, which laid a foundation ...
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#1Hao Lv (Soochow University)H-Index: 1
#2Ce Chao (Soochow University)H-Index: 2
Last. Xiaoying Zhang (Soochow University)H-Index: 17
view all 6 authors...
BACKGROUND The optimal treatment for elderly patients with esophageal cancer (EC) remains controversial. In the present study, we aimed to investigate whether elderly patients with stage II-III EC could benefit from trimodal therapy. METHODS The selected elderly patients with stage II-III EC between 2004 and 2015 were included in a retrospective cohort study from the Surveillance, Epidemiology, and End Results database. The patients were divided into two groups based on whether or not they under...
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#1Huajun Cai (FJMU: Fujian Medical University)
#2Tianbao Xu (FJMU: Fujian Medical University)
Last. Guoxian Guan (FJMU: Fujian Medical University)H-Index: 8
view all 9 authors...
PURPOSE To evaluate the impact of the log odds of positive lymph nodes (LODDS) on cancer-specific survival (CSS) in colon mucinous adenocarcinoma (MAC) patients, compared with pN stage and the lymph nodes ratio (LNR). METHODS A total of 10,182 colon MAC patients from the Surveillance, Epidemiology, and End Results database were divided into the training group. The external validation group included 153 patients from Fujian Medical University Union Hospital. The Cox regression method was used to ...
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#1Enrica BalzaH-Index: 26
#2Sebastiano CarloneH-Index: 16
Last. Patrizia CastellaniH-Index: 34
view all 9 authors...
Triple negative breast cancers (TNBCs) are very aggressive and have a poor prognosis due to lack of efficacious therapies. The only effective treatment is chemotherapy that however is frequently hindered by the occurrence of drug resistance. We approached this problem in vitro and in vivo on a triple negative and a hormone sensitive breast cancer cell lines: 4T1 and TS/A. A main defense mechanism of tumors is the extrusion of intracellular protons derived from the metabolic shift to glycolysis, ...
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#1Vishal A. Patel (GWU: George Washington University)H-Index: 6
#2Catherine McCullum (GWU: George Washington University)
Last. Anokhi Jambusaria-Pahlajani (The University of Texas at Austin)H-Index: 13
view all 6 authors...
PURPOSE This study aims to determine whether there is consensus regarding staging and management of cutaneous squamous cell carcinoma (CSCC) across the various specialties that manage this disease. MATERIALS AND METHODS A survey regarding CSCC high-risk features, staging, and management was created and emailed to cutaneous oncology experts including dermatology, head and neck surgery/surgical oncology, radiation oncology, and medical oncology. RESULTS One hundred fifty-six (46%) of 357 invited p...
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#1Shunhao Zhang (Nantong University)H-Index: 1
#2Jing Sun (Nantong University)H-Index: 1
Last. Xudong Wang (Nantong University)
view all 5 authors...
BACKGROUND Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. According to the research of circular RNAs in the CRC field, compared with linear RNAs, circular RNAs are a special type of noncoding RNA that are covalently closed circular structures, which have no 5' cap structure and 3' polyA tail and are not affected by RNA exonuclease and actinomycin D. BIOLOGICAL FUNCTIONS Notably, circular RNAs have a high degree of stability and potential effect on gene...
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#1David SpanerH-Index: 21
#2Yuxuan Luo (University of Toronto)H-Index: 1
Last. Yonghong Shi (Sunnybrook Research Institute)H-Index: 11
view all 6 authors...
Preclinical observations that killing of chronic lymphocytic leukemia (CLL) cells was dexamethasone (DEX) were enhanced by concomitant inhibition of Bruton's tyrosine kinase and janus kinases (JAKs) motivated a phase II trial to determine if clinical responses to ibrutinib could be deepened by DEX and the JAK inhibitor ruxolitinib. Patients on ibrutinib at 420 mg daily for 2 months or with abnormal serum β2M levels after 6 months or with persistent lymphadenopathy or splenomegaly after 12 months...
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#1Miles E. Cameron (UF: University of Florida)H-Index: 6
#2Patrick W. Underwood (UF: University of Florida)H-Index: 9
Last. Andrew Judge (UF: University of Florida)H-Index: 67
view all 8 authors...
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of all common malignancies. Treatment is difficult and often complicated by the presence of cachexia. The clinical portrait of cachexia contributes to the poor prognosis experienced by PDAC patients and worsens therapeutic outcomes. We propose that low bone mineral density is a component of cachexia, which we explore herein through a retrospective review of all patients at our facility that underwent surgery for PDAC between 2011 and...
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