Cancer Medicine
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#1Anna Lee (University of Texas MD Anderson Cancer Center)H-Index: 12
#2Jung Julie Kang (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 5
Last. Nancy Y. Lee (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 84
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Patients with previously treated, recurrent or metastatic sarcomas who have progressed on multiples lines of systemic therapy may have limited options for local control. We evaluated outcomes of palliative proton therapy with the quad shot regimen to unresectable disease for patients with recurrent and/or metastatic sarcoma. From 2014 to 2018, 28 patients with recurrent or metastatic sarcomas were treated to 40 total sites with palliative proton RT with quad shot (14.8 Gy/4 twice daily). Outcome...
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#1Helga H. HektoenH-Index: 2
#2Trude Eid RobsahmH-Index: 26
Last. Bettina Kulle AndreassenH-Index: 12
view all 8 authors...
BACKGROUND High circulating levels of vitamin D (25(OH)D) are suggested to reduce the risk of urinary bladder cancer (BC), but the evidence is weak, and several studies lack sufficient adjustment for potential confounders (e.g., smoking, body mass index (BMI), and physical activity). Moreover, few studies have investigated the role of vitamin D-binding protein (DBP) in this context. We conducted a matched nested case-control study including 378 cases and 378 controls within the Norwegian populat...
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#1Jason A Mouabbi (BCM: Baylor College of Medicine)H-Index: 3
Last. Valentina Hoyos (BCM: Baylor College of Medicine)H-Index: 14
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OBJECTIVE The goal was to compare the 5-year DFS and 5-year OS in patients with early-stage human epidermal growth factor receptor 2 breast cancer (HER2+ BC) and triple-negative breast cancer (TNBC) in relation to the amount of stromal tumor-infiltrating lymphocytes (TILs) after locoregional management by either mastectomy without radiation or lumpectomy and whole-breast radiotherapy (RT). METHODS This was a retrospective review of HER2+ BC and TNBC patients' charts and histopathology slides wit...
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#1Huy Gia Vuong (OU: University of Oklahoma)H-Index: 15
#2Tam N.M. Ngo (Pham Ngoc Thach University of Medicine)H-Index: 4
Last. Ian F. Dunn (OU: University of Oklahoma)H-Index: 67
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INTRODUCTION IDH1/2 mutations are prevalent in cartilaginous tumors including chondrosarcoma. This meta-analysis using individual patient data (IPD) aimed to investigate the clinical and prognostic association of these mutations in chondrosarcoma patients. METHODS Two electronic databases including PubMed and Web of Science were searched for relevant data. We included studies providing IPD of chondrosarcoma with available IDH1/2 mutational status for meta-analysis. Chi-square and t-test were per...
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#1Markus W. Haun (Heidelberg University)H-Index: 9
#2Laura Simon (University of Ulm)
Last. Mechthild Hartmann (Heidelberg University)H-Index: 24
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BACKGROUND The purpose of this study was to explore predictors for anxiety as the most common form of psychological distress in cancer survivors while accounting for physical comorbidity. METHODS We conducted a secondary data analysis of a large study within the German National Cancer Plan which enrolled primary care cancer survivors diagnosed with colon, prostatic, or breast cancer. We selected candidate predictors based on a systematic MEDLINE search. Using supervised machine learning, we deve...
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#1Jiayi Shen (SYSU: Sun Yat-sen University)H-Index: 6
#2Huaqiang Zhou (SYSU: Sun Yat-sen University)H-Index: 12
Last. Li Zhang (SYSU: Sun Yat-sen University)H-Index: 65
view all 9 authors...
BACKGROUND There has been no study systematically assessing the causal effects of putative modifiable risk factors on lung cancer. In this study, we aimed to construct a modifiable risk factors atlas of lung cancer by using the two-sample Mendelian randomization framework. METHODS We included 46 modifiable risk factors identified in previous studies. Traits with p-value smaller than 0.05 were considered as suggestive risk factors. While the Bonferroni corrected p-value for significant risk facto...
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#1Xuan Li (Fudan University)
#2He-Fen Sun (Fudan University)H-Index: 9
Last. Wei Jin (Fudan University)H-Index: 78
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AIMS Prognosis of patients for human epidermal growth factor receptor 2 (HER2)-negative breast cancer post neoadjuvant chemotherapy is not well understood. The aim of this study was to develop a novel pharmacophore-based signature to better classify and predict the risk of HER2-negative patients after anthracycline-and/or taxane-based neoadjuvant chemotherapy (NACT). MAIN METHODS Anthracycline and taxane pharmacophore-based genes were obtained from PharmMapper. Drug-targeted genes (DTG) related ...
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#1Luca F. Valle (UCLA: University of California, Los Angeles)H-Index: 8
#2Fang-I Chu (UCLA: University of California, Los Angeles)H-Index: 8
Last. Ann C. Raldow (UCLA: University of California, Los Angeles)H-Index: 12
view all 7 authors...
PURPOSE Though utilization of medical procedures has been shown to vary considerably across the United States, similar efforts to characterize variation in the delivery of radiation therapy (RT) procedures have not been forthcoming. Our aim was to characterize variation in the delivery of common RT procedures in the Medicare population. We hypothesized that delivery would vary significantly based on provider characteristics. METHODS The Centers for Medicare and Medicaid Services (CMS) Physician ...
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#1Marcela B. Mansur (ICR: Institute of Cancer Research)H-Index: 9
#2Caroline L Furness (ICR: Institute of Cancer Research)H-Index: 7
Last. Frederik W. van Delft (ICR: Institute of Cancer Research)H-Index: 12
view all 17 authors...
BACKGROUND Treatment on risk adapted intensive pediatric protocols has improved outcome for teenagers and young adults (TYA) with T-cell acute lymphoblastic leukemia (T-ALL). Understanding the biology of disease in this age group and the genetic basis of relapse is a key goal as patients with relapsed/refractory disease have poor outcomes with conventional chemotherapy and novel molecular targets are required. This study examines the question of whether TYA T-ALL has a specific biological-molecu...
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#1Yujia Lan (HMU: Harbin Medical University)H-Index: 11
#2Wei Liu (HMU: Harbin Medical University)H-Index: 4
Last. Yun Xiao (HMU: Harbin Medical University)H-Index: 24
view all 9 authors...
BACKGROUND Lung adenocarcinoma (LUAD), as the most common subtype of lung cancer, is the leading cause of cancer deaths in the world. The accumulation of driver gene mutations enables cancer cells to gradually acquire growth advantage. Therefore, it is important to understand the functions and interactions of driver gene mutations in cancer progression. METHODS We obtained gene mutation data and gene expression profile of 506 LUAD tumors from The Cancer Genome Atlas (TCGA). The subtypes of tumor...
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