Acta Pharmaceutica Sinica B
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7.10
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809
Papers 1189
1 page of 119 pages (1,189 results)
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#1Yesi Shi (Ha Tai: Xiamen University)H-Index: 6
#2Hongyan Qian (Ha Tai: Xiamen University)H-Index: 6
Last. Zhongning Lin (Ha Tai: Xiamen University)H-Index: 10
view all 7 authors...
Abstract null null Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases, which involve plenty of immune cells, pathogens and autoantibodies. Nanomedicine has a great potential in modulating immune system. Particularly, biomimetic nanomodulators can be designed for prevention, diagnosis and therapy to achieve a better targeted immunotherapy. With the development of materials science and bioengineering, a wide range of me...
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#1Hartmut Jaeschke (KU: University of Kansas)H-Index: 119
#2Olamide B Adelusi (KU: University of Kansas)
Last. Anup Ramachandran (KU: University of Kansas)H-Index: 58
view all 8 authors...
Abstract null null Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human pathophysiology. As a result, this clinically relevant model is frequently used to study mechanisms of drug-induced liver injury and even more so to test potential therapeutic interventions. However, the complexity of the model req...
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#1Xu Zhang (CAS: Chinese Academy of Sciences)H-Index: 24
#2Yu-xiang Wang (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Linghua Meng (CAS: Chinese Academy of Sciences)H-Index: 29
view all 3 authors...
Abstract null null Esophageal cancer is one of the most lethal cancers worldwide because of its rapid progression and poor prognosis. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are two major subtypes of esophageal cancer. ESCC predominantly affects African and Asian populations, which is closely related to chronic smoking and alcohol consumption. EAC typically arises in Barrett’s esophagus with a predilection for Western countries. While surgical operation and ...
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#1Yuyun Tang (SJTU: Shanghai Jiao Tong University)
#2Jinchao Gao (SJTU: Shanghai Jiao Tong University)
Last. Xiaoling Gao (SJTU: Shanghai Jiao Tong University)H-Index: 16
view all 9 authors...
Abstract null null The presence of protein corona on the surface of nanoparticles modulates their physiological interactions such as cellular association and targeting property. It has been shown that α-mangostin (αM)-loaded poly(ethylene glycol)-poly(L-lactide) (PEG-PLA) nanoparticles (NP-αM) specifically increased low density lipoprotein receptor (LDLR) expression in microglia and improved clearance of amyloid beta (Aβ) after multiple administration. However, how do the nanoparticles cross the...
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#1Deyan Wu (SYSU: Sun Yat-sen University)H-Index: 10
#2Xuehua Zheng (Guangzhou Medical University)H-Index: 3
Last. Yi-You Huang (SYSU: Sun Yat-sen University)H-Index: 14
view all 11 authors...
Abstract null null Scaffold hopping refers to computer-aided screening for active compounds with different structures against the same receptor to enrich privileged scaffolds, which is a topic of high interest in organic and medicinal chemistry. However, most approaches cannot efficiently predict the potency level of candidates after scaffold hopping. Herein, we identified potent PDE5 inhibitors with a novel scaffold via a free energy perturbation (FEP)-guided scaffold-hopping strategy, and FEP ...
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#1Yang HeH-Index: 4
#2Yuefei Fang (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Yongzhuo HuangH-Index: 36
view all 10 authors...
Abstract null null There is a close connection between epigenetic regulation, cancer metabolism, and immunology. The combination of epigenetic therapy and immunotherapy provides a promising avenue for cancer management. As an epigenetic regulator of histone acetylation, panobinostat can induce histone acetylation and inhibit tumor cell proliferation, as well as regulate aerobic glycolysis and reprogram intratumoral immune cells. JQ1 is a BRD4 inhibitor that can suppress PD-L1 expression. Herein,...
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#1Pearl Moharil (University of Pittsburgh)H-Index: 1
#2Zhuoya Wan (University of Pittsburgh)H-Index: 5
Last. Bei Zhang (University of Pittsburgh)H-Index: 1
view all 13 authors...
Abstract null null Combination of passive targeting with active targeting is a promising approach to improve the therapeutic efficacy of nanotherapy. However, most reported polymeric systems have sizes above 100 nm, which limits effective extravasation into tumors that are poorly vascularized and have dense stroma. This will, in turn, limit the overall effectiveness of the subsequent uptake by tumor cells via active targeting. In this study, we combined the passive targeting via ultra-small-size...
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#1Guoping Shu (SWU: Southwest University)
#2Yueli Tang (SWU: Southwest University)
Last. Lien Xiang (CWNU: China West Normal University)
view all 11 authors...
Abstract null null Artemisia annua is the main natural source of artemisinin production. In A. annua, extended drought stress severely reduces its biomass and artemisinin production while short-term water-withholding or abscisic acid (ABA) treatment can increase artemisinin biosynthesis. ABA-responsive transcription factor AabZIP1 and JA signaling AaMYC2 have been shown in separate studies to promote artemisinin production by targeting several artemisinin biosynthesis genes. Here, we found AabZI...
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#1Danyu Du (CPU: China Pharmaceutical University)H-Index: 4
#2Chan Liu (CPU: China Pharmaceutical University)
Last. Jing Xiong (CPU: China Pharmaceutical University)H-Index: 11
view all 8 authors...
Abstract null null Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat HCC, such as targeted tyrosine kinase inhibitors, immune based therapies and combination of chemotherapy. However, limitations exist in current strategies including chemoresistance for instance. Tumor initiation and progression is driven by reprogramming of metabolism, in particular during HCC development...
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#1Yu-Hong Zhang (SYSU: Sun Yat-sen University)H-Index: 3
#2Yanqing Ding (SYSU: Sun Yat-sen University)H-Index: 2
Last. Peiqing Liu (SYSU: Sun Yat-sen University)H-Index: 60
view all 9 authors...
Abstract null null Pathological cardiac hypertrophy serves as a significant foundation for cardiac dysfunction and heart failure. Recently, growing evidence has revealed that microRNAs (miRNAs) play multiple roles in biological processes and participate in cardiovascular diseases. In the present research, we investigate the impact of miRNA-34c-5p on cardiac hypertrophy and the mechanism involved. The expression of miR-34c-5p was proved to be elevated in heart tissues from isoprenaline (ISO)-infu...
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