Papers 10,000
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#1Christopher I Jarvis (University of London)H-Index: 30
#2Amy GimmaH-Index: 19
Last. Thibaut JombartH-Index: 49
view all 9 authors...
The fraction of cases reported, known as reporting, is a key performance indicator in an outbreak response, and an essential factor to consider when modelling epidemics and assessing their impact on populations. Unfortunately, its estimation is inherently difficult, as it relates to the part of an epidemic which is, by definition, not observed. We introduce a simple statistical method for estimating reporting, initially developed for the response to Ebola in Eastern Democratic Republic of the Co...
#1Marco S. Kaiser (University of Basel)H-Index: 1
#2G. Milan (University of Basel)
Last. Markus A. Rüegg (University of Basel)H-Index: 75
view all 12 authors...
Muscle size is controlled by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which integrates signals from growth factors, energy and amino acids to activate protein synthesis and inhibit protein breakdown. While mTORC1 activity is necessary for PKB/Akt-induced muscle hypertrophy, its constant activation alone induces muscle atrophy. Here we show that this paradox is based on mTORC1 activity promoting protein breakdown through the ubiquitin-proteasome system (UPS) by simultaneously inducing ubiquitin E3 l...
#1Kevin O. Rivera (UCSF: University of California, San Francisco)H-Index: 4
#2Darnell L. Cuylear (UCSF: University of California, San Francisco)
Last. Tejal A. Desai (UCSF: University of California, San Francisco)H-Index: 78
view all 9 authors...
Currently, there are no biological approaches to accelerate bone fracture repair. Osteobiologics that promote endochondral ossification are an exciting alternative to surgically implanted bone grafts, however, the translation of osteobiologics remains elusive because of the need for localized and sustained delivery that is both safe and effective. In this regard, an injectable system composed of hydrogel-based microparticles designed to release osteobiologics in a controlled and localized manner...
#1Silvia Zaoli (ICTP: International Centre for Theoretical Physics)H-Index: 5
#2Jacopo GrilliH-Index: 21
The large taxonomic variability of microbial community composition is a consequence of the combination of environmental variability, mediated through ecological interactions, and stochasticity. Most of the analysis aiming to infer the biological factors determining this difference in community structure start by quantifying how much communities are similar in their composition, trough beta-diversity metrics. The central role that these metrics play in microbial ecology does not parallel with a q...
#1Jake Leighton (The University of Texas MD Anderson Cancer Center)
#2Min Hu (The University of Texas MD Anderson Cancer Center)H-Index: 5
Last. Nicholas Navin (The University of Texas MD Anderson Cancer Center)H-Index: 37
view all 5 authors...
Single cell DNA sequencing (scDNA-seq) methods are powerful tools for profiling mutations in cancer cells, however most genomic regions characterized in single cells are non-informative. null To overcome this issue, we developed a Multi-Patient-Targeted (MPT) scDNA-seq sequencing method. null MPT involves first performing bulk exome sequencing across a cohort of cancer patients to identify somatic mutations, which are then pooled together to develop a single custom targeted panel for high-throug...
#1Weihong Qi (ETH Zurich: ETH Zurich)H-Index: 20
Last. Wilhelm Gruissem (NCHU: National Chung Hsing University)H-Index: 106
view all 14 authors...
Background: Cassava (Manihot esculenta) is an important clonally propagated food crop in tropical and sub-tropical regions worldwide. Genetic gain by molecular breeding is limited because cassava has a highly heterozygous, repetitive and difficult to assemble genome. Findings: Here we demonstrate that Pacific Biosciences high-fidelity (HiFi) sequencing reads, in combination with the assembler hifiasm, produced genome assemblies at near complete haplotype resolution with higher continuity and acc...
#1Kevin A. BirdH-Index: 9
Last. Patrick P. EdgerH-Index: 36
view all 5 authors...
Allopolyploidy involves the hybridization of two evolutionary diverged species and the doubling of genomic material. Frequently, allopolyploids exhibit genomic rearrangements that recombine, duplicate, or delete homoeologous regions of the newly formed genome. While decades of investigation have focused on how genome duplication leads to systematic differences in the retention and expression of duplicate genes, the impact of genomic rearrangements on genome evolution has received less attention....
#1Richa Batra (CU: Cornell University)H-Index: 10
#2Matthias Arnold (Duke University)H-Index: 20
Last. Jan Krumsiek (CU: Cornell University)H-Index: 35
view all 13 authors...
We present a comprehensive reference map of metabolic brain changes in Alzheimer's disease (AD). In a multi-center study within the Accelerating Medicines Partnership in AD, we metabolically profiled 500 samples from the dorsolateral prefrontal cortex (DLPFC) and 83 samples from the temporal cortex (TCX). In the DLPFC, 298 metabolites were correlated with AD-related traits, including late-life cognitive performance and neuropathological {beta}-amyloid and tau tangle burden. Out of these 298 meta...
#1Uzozie, Anuli, Smith, Theodore, Chen, Siyuan, Lange, Philipp (UBC: University of British Columbia)
#2Theodore G. SmithH-Index: 1
Last. Philipp F. LangeH-Index: 20
view all 1 authors...
The cleavage-site specificities for many proteases are not well-understood, restricting the utility of supervised classification methods. We present an algorithm and web interface to overcome this limitation through the unsupervised detection of overrepresented patterns in protein sequence data, providing insight into the mixture of protease activities contributing to a complex system. Here, we apply the RObust LInear Motif Deconvolution (RoLiM) algorithm to confidently detect substrate cleavage...
#1K. M. Snyder (The University of Texas Health Science Center at Houston)
#2Kiefer James Forseth (The University of Texas Health Science Center at Houston)H-Index: 7
Last. Nitin Tandon (The University of Texas Health Science Center at Houston)H-Index: 29
view all 7 authors...
Deficits in word retrieval are a hallmark of a variety of neurological illnesses spanning from dementia to traumatic injuries. The role of the dominant temporal lobe in fluent naming has been characterized by lesional analyses, functional imaging, and intracranial recordings, but limitations of each of these measures preclude a clear assessment of which specific constituent of the temporal lobe is critical for naming. We studied a large cohort of patients undergoing surgical resections or laser ...
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