Free Radical Research
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#1Nayanne Hardy Lima Pontes (UFC: Federal University of Ceará)H-Index: 1
#2Thomas Dominik de Sousa Dos Reis (UFC: Federal University of Ceará)H-Index: 1
Last. Rodrigo Maranguape Silva da Cunha (Universidade Estadual do Vale do Acaraú)H-Index: 11
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Oxidative stress is involved in many pathological disturbs, such as neurodegenerative disorders. Eugenol (Eug) is a phenolic compound with antioxidant and neuroprotective activities. Then, the present study was conducted to investigate the potential neuroprotective effects of Eug on oxidative stress model induced by 6-hydroxydopamine (6-OHDA) in rats. Firstly, the in vivo oxidative stress model was performed by intrastriatal injection (int.) of 6-OHDA (21 µg), followed by the treatment of Eug (0...
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#1Anjali Sharma (JU: Jiwaji University)H-Index: 2
#2Sadhana Shrivastava (JU: Jiwaji University)H-Index: 14
Last. Sangeeta Shukla (JU: Jiwaji University)H-Index: 20
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The study aimed to discover a link between the liver and brain's functional status due to frequency dependent-radiofrequency electromagnetic radiation (RF-EMR). Forty Wistar rats were randomly classified as control (sham-exposed) and EMR exposed groups. Animals were exposed to 900, 1800, and 2100 MHz with the specific absorption rate (SAR) 0.434 (W/Kg), 0.433 (W/Kg), and 0.453 (W/Kg) respectively. Animal exposure was limited at 1 h/day, 5 days/week for 1 month with a restricted power density (90...
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#1Oluwatosin O. Ojo (University of Reading)H-Index: 1
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Low density lipoprotein (LDL) might be oxidised by iron in the lysosomes of macrophages in atherosclerotic lesions. We have shown previously that the iron-storage protein ferritin can oxidise LDL at lysosomal pH. We have now investigated the roles of the most important antioxidant contained in LDL, α-tocopherol (the main form of vitamin E) and of ascorbate (vitamin C), a major water-soluble antioxidant, on LDL oxidation by ferritin at lysosomal pH (pH 4.5). We incubated LDL with ferritin at pH 4...
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#1Chong Bao (WHU: Wuhan University)
#2Jing Zhang (WHU: Wuhan University)
Last. Feng Chen (WHU: Wuhan University)
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Glioblastoma is one of the most frequent malignant tumors derived from the brain in adults with very poor prognosis. Ferroptosis is implicated in the initiation and progression of various tumors, including the glioblastoma. The present study aims to investigate the function of microRNA (miR)-670-3p in glioblastoma, and tries to demonstrate whether ferroptosis is involved in this process. Human glioblastoma cell lines, U87MG and A172, were transfected with the inhibitor, mimic and matched negativ...
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#1Dong Wei (HUM: Hubei University of Medicine)
#2Bao-Xue Duan (HUM: Hubei University of Medicine)
Last. Ping Cao (HUM: Hubei University of Medicine)
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Ferroptosis is a newly described regulatedform ofcell deaththat contributes to the progression of non-small cell lung cancers (NSCLCs). MicroRNA-302a-3p (miR-302a-3p) plays critical roles in thetumorigenicity of different cancers; however, its function and underlying mechanism in ferroptosis and NSCLCs remain unclear.Human NSCLCs cells were incubated with miR-302a-3pmimic or inhibitorin the presence or absence of erastinor RSL3. Cell viability, colony numbers, lactate dehydrogenase (LDH) release...
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#2Camila R. Ferraz (UEL: Universidade Estadual de Londrina)H-Index: 7
Last. Sergio M. Borghi (UEL: Universidade Estadual de Londrina)H-Index: 17
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The mechanistic interactions among redox status of leukocytes, muscle, and exercise in pain regulation are still poorly understood and limit targeted treatment. Exercise benefits are numerous, including the treatment of chronic pain. However, unaccustomed exercise may be reported as undesirable as it may contribute to pain. The aim of the present review is to evaluate the relationship between oxidative metabolism and acute exercise-induced pain, and as to whether improved antioxidant capacity un...
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#1Tadashi Tsukamoto (Mie University)
#2Masaya Tsujii (Mie University)H-Index: 12
Last. Akihiro Sudo (Mie University)H-Index: 44
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Cachexic condition due to malignant tumors has been a challenging problem. The aim of this study is to analyze effects of febuxostat on both in vitro and in vivo models of the wasting of skeletal muscles, due to LM8 osteosarcoma cells. C2C12 myotubes were incubated in the conditioned medium of LM8. Febuxostat was added at a concentration of 3 µM and 30 µM, and ROS, diameter of myotubes, and expression of atrogin-1 were analyzed. Furthermore, an in vivo study was performed by subcutaneous injecti...
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#1Ryo Koizumi (Shibaura Institute of Technology)H-Index: 1
#2Taiki Fushimi (Shibaura Institute of Technology)H-Index: 1
Last. Naomi Osakabe (Shibaura Institute of Technology)H-Index: 34
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We previously found that a single dose of B type procyanidin mixture increase in skeletal muscle blood flow (BF). We compared BF changes following administration of (-)-epicatechin (EC, monomer) and the B type procyanidins procyanidin B2 (B2, dimer), procyanidin C1 (C1, trimer), and cinnamtannin A2 (A2, tetramer). Each chemical was administered orally to rats, followed by BF measurement in cremaster arteriole for 60 min. 10 and 100 microg/kg of B2 and C1 elicited BF increase, the effect was pote...
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#1Tatjana RuskovskaH-Index: 12
#2Piet Beekhof (Centre for Health Protection)H-Index: 12
Last. Eugene Jansen (Centre for Health Protection)H-Index: 34
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Various biomarkers of oxidative stress and redox status have been used in a number of clinical and epidemiological studies related to diseases and conditions that involve disturbances of the redox balance. However, a comprehensive study of diurnal variations of a set of biomarkers has not been conducted so far. Therefore, the aim of this study is to investigate circadian rhythm and time-of-day-effects of a set of frequently used biomarkers of oxidative stress, redox and antioxidant status in ser...
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#1Yuki Kakihana (OPU: Osaka Prefecture University)H-Index: 3
#2Shingo Kasamatsu (OPU: Osaka Prefecture University)H-Index: 17
Last. Hideshi Ihara (OPU: Osaka Prefecture University)H-Index: 27
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Imidazole-containing dipeptides (IDPs), such as carnosine and anserine, are endogenously produced and have been shown to function as antioxidants. Recently, we have characterized the endogenous production of 2-oxo-imidazole-containing dipeptides (2-oxo-IDPs), such as 2-oxo-carnosine, 2-oxo-anserine, and 2-oxo-homocarnosine in mouse tissues, including brain, and demonstrated that 2-oxo-IDPs exhibit higher antioxidant activities than the corresponding IDPs. In this study, we established a highly s...
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Top fields of study
Chemistry
Oxidative stress
Antioxidant
Reactive oxygen species
Biochemistry