Though liposome-based drugs are in clinical use, the mechanism of cell internalization of liposomes is yet an object of controversy. The present experimental investigation, carried out on human glioblastoma cells, indicated different internalization routes for two diastereomeric liposomes. Molecular dynamics simulations of the lipid bilayers of the two formulations indicated that the different stereochemistry of a lipid component controls some parameters such as area per lipid molecule and fluid...
#2Lujun Pan(DUT: Dalian University of Technology)H-Index: 17
Last. Yongpeng Zhao(DUT: Dalian University of Technology)H-Index: 6
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Well-organized substrate materials are of considerable significance in the development of energy-efficient pseudocapacitor electrodes. Herein, functionalized three-dimensional (3D) carbon nanocoils on nickel foam (CNCs/NF) have been used as the substrate to grow faradaic nickel cobaltite (NiCo2O4) via a solvothermal method. The arrays of NiCo2O4 were assembled by interconnected ultrathin nanosheets with random inter-particle pores. The number of electroactive sites increased specifically because...
Chlorin e6 (Ce6) is a widely utilized photosensitizer in photodynamic therapy (PDT) against tumor growth, but its hydrophobic feature and the hypoxia in the tumor microenvironment greatly compromise its therapeutic efficacy. To address the issues, here we designed a new Ce6 derivative (TCe6) by coupling Ce6 with amphiphilic d-α-tocopherol polyethylene glycol 1000 succinate (TPGS), endowing Ce6 with an excellent amphiphilic feature. In particular, the overall reactive oxygen species (ROS) generat...
Novel preparative approaches towards lamellar nanocomposites of carbon and inorganic materials are relevant for a broad range of technological applications. Here, we describe how to utilize the co-assembly of a liquid-crystalline hexaphenylene amphiphile and an aluminosilicate precursor to prepare carbon-aluminosilicate nanocomposites with controlled lamellar orientation and macroscopic order. To this end, the shear-induced alignment of a precursor phase of the two components resulted in thin fi...
Cage forming proteins have numerous potential applications in biomedicine and biotechnology, where the iron storage ferritin is a widely used example. However, controlling ferritin cage assembly/disassembly remains challenging, typically requiring extreme conditions incompatible with many desirable cargoes, particularly for more fragile biopharmaceuticals. Recently, a ferritin from the hyperthermophile bacterium Thermotoga maritima (TmFtn) has been shown to have reversible assembly under mild co...
We developed a water-soluble, stable and selective “turn-on” fluorescent sensing platform based on carbon quantum dots (CQDs) for rapid determination of the phosphate (Pi) in aqueous solutions and visualization of latent fingerprints on paper. The hydroxyl groups on the surface of synthesized CQDs can be deprotonated by Pi to trigger the intramolecular charge transfer (ICT) process and inhibition of excited-state proton transfer (ESPT), achieving the turn-on emission response. CQDs demonstrated ...
Last. Anna Klinkova(UW: University of Waterloo)H-Index: 16
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Shape and surface chemistry control in copper nanoparticle synthesis is an important research area due to a wide range of developing applications of this material in catalysis, energy conversion, sensing and many others. In addition to being an inexpensive and abundant metal, copper is an attractive photocatalyst due to its optical properties in the visible range. Here, we report a facile, tunable and sustainable methodology for synthesizing Pd-seeded Cu nanoparticles with various shapes, includ...
#1Hongze Fang(HIT: Harbin Institute of Technology)H-Index: 10
#2Shu Wang(HIT: Harbin Institute of Technology)H-Index: 3
Last. Jingjie Guo(HIT: Harbin Institute of Technology)H-Index: 25
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In order to acquire TiAl composites with a multi-scale reinforcing phase, and to improve the microstructure and tensile properties at elevated temperatures, TiAl alloys have been prepared with different added carbon content levels via vacuum arc melting. The results show that when the carbon content is greater than or equal to 1.0 at%, then Ti2AlC forms and the microstructure changes from having a dendrite morphology to an equiaxed crystal morphology. The B2 phase disappears in the Ti2AlC-contai...
Developing effective electrocatalysts for oxygen reduction reaction is of great significance for clean and renewable energy technologies, such as metal–air batteries and fuel cells. Defect engineering is the central focus of this field because overall catalytic performance crucially depends on highly active defects. For the ORR, topological defects have been proven to have a positive effect. However, because preparing and characterizing such defects are difficult, a basic understanding of the re...
We report experimental results on damage induced by ionizing radiation to DNA origami triangles which are commonly used prototypes for scaffolded DNA origami nanostructures. We demonstrate extreme stability of DNA origami upon irradiation, which is caused by (i) the multi-row design holding the shape of the origami even after severe damage to the scaffold DNA and (ii) the reduction of damage to the scaffold DNA due to the protective effect of the folded structure. With respect to damage induced ...