Ophthalmology
IF
12.08
Papers
17.8k
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#1Sanjeeb BhandariH-Index: 6
#2Susan VitaleH-Index: 57
Last. Emily Y. ChewH-Index: 102
view all 5 authors...
Purpose null To evaluate the risk of developing late age-related macular degeneration (AMD) following incident cataract surgery. null Design null A prospective cohort study within a randomized controlled clinical trial of oral supplementation for the treatment of AMD - the Age-Related Eye Disease Study 2 (AREDS2). null Participants null AREDS2 participants aged 50 to 85 years with either bilateral large drusen or unilateral late AMD. null Methods null In eyes that were free of cataract surgery a...
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#1Mathilde Leclercq (University of Paris)H-Index: 3
#2Anaïs Andrillon (Saint Louis University Hospital)
Last. David Saadoun (University of Paris)H-Index: 73
view all 18 authors...
Abstract null null Objective null To analyze the factors associated with response (control of ocular inflammation and corticosteroid sparing effect) to biologics (anti-TNF-α agents and tocilizumab) in patients with refractory uveitic macular edema. null null null Design null Multicenter retrospective observational study. null null null Subjects null Adult patients with uveitic macular edema refractory to systemic corticosteroids and/or disease modifying anti-rheumatic drugs. null null null Metho...
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#1Maria Chiara Gelmi (LUMC: Leiden University Medical Center)
#2Zeynep Bas (Thomas Jefferson University)H-Index: 2
Last. Martine J. Jager (LUMC: Leiden University Medical Center)H-Index: 59
view all 6 authors...
ABSTRACT null null Purpose null Uveal melanoma (UM) is a rare disease and the most common primary intraocular malignancy in adults, with a high risk of metastases. Reliable prognostication systems are based on anatomical features, as in the Tumor Node Metastasis / American Joint Committee on Cancer (TNM/AJCC) staging, or on genetic information, as in The Cancer Genome Atlas (TCGA) system. Prior evidence suggests that combining both systems may be beneficial. We evaluated the benefit of combining...
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#1Annemijn P. A. Wierenga (LUMC: Leiden University Medical Center)H-Index: 7
#2Niels J. Brouwer (LUMC: Leiden University Medical Center)H-Index: 9
Last. Martine J. Jager (LUMC: Leiden University Medical Center)H-Index: 59
view all 14 authors...
PURPOSE Individuals with gray, blue, or green iris have a higher chance of developing uveal melanoma (UM) than those with brown eyes. We wondered whether iris pigmentation might not only be related to predisposition to UM, but also to its behavior and therefore compared clinical, histopathologic, and genetic characteristics of UM between eyes with different iris colors. DESIGN We determined iris color in a large cohort of patients who had undergone an enucleation for UM. Clinical and histopathol...
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#1Mark S. BlumenkranzH-Index: 70
#2Michelle E. TarverH-Index: 9
Last. Malvina B. EydelmanH-Index: 15
view all 4 authors...
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#1David WirtaH-Index: 7
Last. Jeffrey Nau (Princeton University)H-Index: 7
view all 7 authors...
OBJECTIVE To evaluate the efficacy and safety of OC-01 (varenicline) nasal spray for treatment of patients with dry eye disease. DESIGN Randomized, multicenter, double-masked, vehicle-controlled, phase 3 study. PARTICIPANTS Adults aged 22 years or more with a diagnosis of dry eye disease, artificial tear use, Ocular Surface Disease Index score of 23 or more, and Schirmer's Test Score (STS) of 10 mm or less. Eligibility was not restricted by Eye Dryness Score (EDS). METHODS Patients (N = 758) wer...
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#1Katharina C. Bell (SNEC: Singapore National Eye Center)
#2Mineo Ozaki (University of Miyazaki)H-Index: 17
Last. Tin Aung (NUS: National University of Singapore)H-Index: 109
view all 27 authors...
Abstract null null Purpose null Carriers of functionally deficient mutations in the CYP39A1 gene have been recently reported to have a 2-fold increased risk of exfoliation syndrome (XFS). The aim of this study was to evaluate the risk of blindness and related clinical phenotypes of XFS patients carrying the loss-of-function CYP39A1 G204E mutation in comparison to XFS patients without any CYP39A1 mutation. null null null Design null Retrospective case study null null null Participants null 35 pat...
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#1David A. Quillen (PSU: Pennsylvania State University)H-Index: 21
#2Paul P. Lee (UM: University of Michigan–Ann Arbor)H-Index: 70
Last. Steven E. Feldon (UR: University of Rochester)H-Index: 46
view all 4 authors...
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#1Stéphanie Lemaître (Moorfields Eye Hospital NHS Foundation Trust)H-Index: 3
#2Gordon Hay (Moorfields Eye Hospital NHS Foundation Trust)H-Index: 5
Last. Mandeep S. Sagoo (Moorfields Eye Hospital NHS Foundation Trust)H-Index: 23
view all 3 authors...
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#1Anita de Breuk (Radboud University Nijmegen)H-Index: 5
#2Ilhan Erkin Acar (Radboud University Nijmegen)H-Index: 6
Last. Timo Verzijden (EUR: Erasmus University Rotterdam)H-Index: 8
view all 24 authors...
Abstract Purpose To develop a genotype assay to assess associations with common and rare AMD risk variants, to calculate an overall genetic risk score (GRS), and to identify potential misdiagnoses with inherited macular dystrophies that mimic AMD. Design Case-control study. Participants Individuals (N=4,740) from five European cohorts. Methods We designed single molecule molecular inversion probes (smMIPs) for target selection and used next generation sequencing (NGS) to sequence eighty-seven si...
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