Medical Oncology
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#1Nilgun Karasu (Erciyes University)
#2Hilal Akalin (Erciyes University)H-Index: 5
Last. Munis Dundar (Erciyes University)H-Index: 16
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Imatinib mesylate, a tyrosine kinase inhibitor, is the first choice in chronic myeloid leukemia treatment. However, resistance to imatinib may develop with time and in some cases, patients may not respond at all to imatinib. Progressive resistance to imatinib therapy is often due to mutations in the BCR/ABL region. Within the scope of our study 124 patients were evaluated via pyrosequencing between 2015 and 2020. In this regard, 32 patients who have a partial response and have no response to ima...
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#1Saptarshi Sinha (KIIT: KIIT University)H-Index: 1
#2Sefinew Molla (KIIT: KIIT University)H-Index: 3
Last. Chanakya Nath Kundu (KIIT: KIIT University)H-Index: 26
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Cancer progression requires certain tumorigenic mutations in genes encoding for different cellular and nuclear proteins. Altered expressions of these mutated genes are mediated by post-translational modifications and chromatin remodeling. Chromatin remodeling is mainly regulated by the chromatin remodeling enzyme complexes and histone modifications. Upon DNA damage, Poly-(ADP-ribose) Polymerase1 (PARP1) plays a very important role in the induction of chromatin modifications and activation of DNA...
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#1Weiliang Chen (SDU: Shandong University)H-Index: 6
#2Donghai Wang (SDU: Shandong University)H-Index: 7
Last. Peng Zhao (SDU: Shandong University)H-Index: 9
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#1Ioannis Lamprou (DUTH: Democritus University of Thrace)H-Index: 2
#2Avgi Tsolou (DUTH: Democritus University of Thrace)H-Index: 7
Last. Michael I. Koukourakis (DUTH: Democritus University of Thrace)H-Index: 74
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Lipid metabolism reprogramming is one of the adaptive events that drive tumor development and survival, and may account for resistance to chemotherapeutic drugs. Perilipins are structural proteins associated with lipophagy and lipid droplet integrity, and their overexpression is associated with tumor aggressiveness. Here, we sought to explore the role of lipid droplet-related protein perilipin-3 (PLIN3) in prostate cancer (PCa) chemotherapy. We investigated the role of PLIN3 suppression in docet...
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#1Johann Ebadfardzadeh (University of Gilan)
Last. Roghayeh SheervalilouH-Index: 12
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The third leading cause of cancer-related deaths in the world, colorectal cancer (CRC) is a global health issue that should be addressed in both diagnostics and therapeutics to improve patient survival rate. Today, microarray data analysis is increasingly being used as a novel and effective method for classification of malignancies and making prognostic assessments. Built upon the concept of microarray data analysis and aimed at the identification of CRC-associated genes, our study has adopted a...
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#1Shima Shabani (TMU: Tarbiat Modares University)
#2Mehdi Forouzandeh Moghadam (TMU: Tarbiat Modares University)H-Index: 10
Last. Seyed Latif Mousavi Gargari (Shahed University)H-Index: 16
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Glucose-regulated protein 78 (GRP78) is a well-characterized endoplasmic reticulum (ER) chaperon frequently overexpressed at the surface of tumor cells and associated with tumor survival, metastasis, and chemoresistance. Hence, potential GRP78 binders emerge as promising candidates for cancer therapy and diagnosis. We applied ribosome display to isolate a single-chain variable domain (scFv) specific for the C-terminal domain of a recombinant human GRP78 (CGRP). Six female BALB/c mice were immuni...
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The aim of this study was to determine the effect of lncRNA HIF1A-AS2 on autophagy-associated drug resistance in small cell lung cancer (SCLC) cells. The expression of HIF1A-AS2 was silenced by siRNA in doxorubicin-sensitive H69 and doxorubicin-resistant H69AR cells. Then, cytotoxicity, apoptosis and autophagy analyses were carried out in the normoxic and CoCl2-induced hypoxic environment. The effect of HIF1A-AS2 on the expression levels of genes, which are associated with drug resistance and au...
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#1Ertan Kanbur (Uludağ University)
#2Ahmet Tarik BaykalH-Index: 21
Last. Azmi YerlikayaH-Index: 3
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The ubiquitin-proteasome pathway is an important protein quality control system involved in intracellular homeostasis. To achieve intracellular homeostasis, proteins that are misfolded as a result of translational errors or genetic mutations must be eliminated by the ubiquitin-proteasome pathway. In our previous publications, we determined that 4T1 breast and B16F10 melanoma cancer cells have differential levels of resistance to proteasome inhibitors. Again, in the previous studies, we reported ...
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#1Eman Ghonaim (Tanta University)
#2Sahar M. El-Haggar (Tanta University)H-Index: 7
Last. Suzy F. Gohar (Menoufia University)H-Index: 4
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Cisplatin is used to treat solid malignancies including head and neck cancer. However, nephrotoxicity limits its use. In this study, we looked for a possible protective effect of pantoprazole against cisplatin-induced nephrotoxicity. We used novel biomarkers for early detection of nephrotoxicity. Sixty chemotherapy naive head and neck cancer patients completed the study. Following complete history taking and thorough clinical examination, patients were randomly divided into three groups: 20 pati...
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