European Respiratory Journal
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#1Alienor Campredon (University of Paris)H-Index: 2
#2E. Battistella (INRIA: French Institute for Research in Computer Science and Automation)
Last. Guillaume Chassagnon (University of Paris)H-Index: 9
view all 19 authors...
OBJECTIVES Lumacaftor-ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator known to improve clinical status in people with cystic fibrosis (CF). This study aimed to assess lung structural changes after one year of lumacaftor-ivacaftor treatment, and to use unsupervised machine learning to identify morphological phenotypes of lung disease that are associated with response to lumacaftor-ivacaftor. METHODS Adolescents and adults with CF from the French multicenter rea...
#1Lucia Caiano (Ottawa Hospital Research Institute)H-Index: 5
#2Rhys Sharkey (Ottawa Hospital Research Institute)
Last. Aurélien Delluc (Ottawa Hospital Research Institute)H-Index: 24
view all 6 authors...
Current guidelines suggest that most patients presenting with a first episode of an unprovoked venous thromboembolism (VTE) event be considered for indefinite anticoagulation, as long as their bleeding risk remains acceptably low [1, 2]. However, this exposes a considerable number of patients to long term anticoagulation as 70% of patients with a first unprovoked VTE will have no recurrence [3]. In 2010, a guidance from the International Society on Thrombosis and Haemostasis (ISTH) suggested tha...
#1Thomas Yang Sun (SU: Stanford University)H-Index: 11
#2Grace Hwang (SU: Stanford University)H-Index: 1
Last. Sukhmani K. Padda (SU: Stanford University)H-Index: 18
view all 9 authors...
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is considered a preinvasive lesion that may progress to carcinoid tumor [1]. Histologically, it is marked by a proliferation of neuroendocrine cells that are confined to the basement membrane (neuroendocrine cell hyperplasia; NECH), and/or invaded past the basement membrane (carcinoid tumorlet) [2]. Tumorlets larger than 5 mm are classified as carcinoid tumors. Per the World Health Organization 2021 criteria, DIPNECH can be p...
#1Guang-Shing Cheng (UW: University of Washington)H-Index: 1
#2Scott E. Evans (The University of Texas MD Anderson Cancer Center)H-Index: 25
For millions of people, taking immunosuppressive medication to control or prevent disease is a daily reality [1]. Rheumatologic disease, inflammatory lung disease, organ transplantation and graft- versus -host disease are but a few of the immune dysregulation syndromes that may require short- or long-term immunosuppressive therapy (IST). Patients taking ISTs are frequently regarded as immunocompromised, sharing risks of increased infection susceptibility with cancer patients receiving chemothera...
#1Lata Jayaram (University of Melbourne)H-Index: 8
#2Alain C. Vandal (University of Auckland)H-Index: 21
Last. Conroy Wong (University of Auckland)H-Index: 20
view all 14 authors...
Tiotropium via HandiHaler® is an established long-acting, anticholinergic bronchodilator that prevents exacerbations and improves lung function in patients with COPD. We hypothesized that tiotropium would reduce pulmonary exacerbations and improve lung function in patients with stable bronchiectasis and airflow limitation, and assessed the effect of tiotropium on these outcomes. In a randomised, double-blind, 2-period crossover trial, we recruited adult patients from 3 hospitals in New Zealand. ...
#1Jouneau Stéphane (University of Rennes 1)
#2Mallorie Kerjouan (University of Rennes 1)H-Index: 11
Last. Ronan Thibault (University of Rennes 1)H-Index: 24
view all 3 authors...
#1Cendrine GodetH-Index: 9
#2Francis Couturaud (UBO: University of Western Brittany)H-Index: 32
Last. Jacques CadranelH-Index: 80
view all 30 authors...
Background null In allergic bronchopulmonary aspergillosis (ABPA), prolonged nebulised antifungal treatment may be a strategy for maintaining remission. null Methods null We performed a randomised, single-blind, clinical trial in 30 centres. Patients with controlled ABPA after a 4-month attack treatment (corticosteroids and itraconazole) were randomly assigned to nebulised liposomal-amphotericin-B or placebo for 6 months. The primary outcome was occurrence of a first severe clinical exacerbation...
#1J.N Wessels (VU: VU Amsterdam)H-Index: 2
#2S.A Mouratoglou (VU: VU Amsterdam)H-Index: 1
Last. Frances S. de Man (VU: VU Amsterdam)H-Index: 32
view all 11 authors...
Background null Pulmonary arterial hypertension (PAH) patients have altered right atrial (RA) function and right ventricular (RV) diastolic stiffness. This study assessed the impact of RV diastolic stiffness on RA-RV interaction. null Methods null Low or high end-diastolic elastance (Eed) PAH patients (n=94) were compared to controls (n=31). Treatment response was evaluated in n=62 patients. RV and RA longitudinal strain, RA emptying and RV filling were determined and diastole was divided in a p...
#1Surinder S. Birring (KCL: King's College London)H-Index: 56
#2Donald M. BushnellH-Index: 1
Last. Yoshikazu InoueH-Index: 54
view all 7 authors...
There is a lack of fully validated patient-reported outcome measures for progressive fibrosing interstitial lung disease (PF-ILD). We aimed to validate the King's Brief Interstitial Lung Disease questionnaire (KBILD) for measuring health-related quality of life (HRQoL) in these patients. We also estimated the meaningful change threshold for interpreting stabilisation of HRQoL as a clinical endpoint in PF-ILD, where the current goal of treatment is disease stability and slowing progression. This ...
#1Henan Xin (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 10
#2Xuefang Cao (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 4
Last. Lei Gao (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 26
view all 19 authors...
BACKGROUND Enlarging tuberculosis (TB) preventive treatment among at-risk populations is a critical component of the End TB Strategy. It is urgently needed to develop suitable latent tuberculosis infection (LTBI) testing and treatment tools according to local TB epidemic and available resources in worldwide. METHODS Based on an open-labeled randomised controlled trial conducted since 2015 among rural residents aged 50-70 years with LTBI, the protective efficacy of the 6-week twice-weekly regimen...
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