European Respiratory Journal
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#1Sanjay Ramakrishnan (University of Oxford)H-Index: 5
#2Simon Couillard (University of Oxford)H-Index: 1
Despite current guidelines advising against, GPs commonly prescribe antibiotics with steroids for asthma attacks. The uncertainty caused by a symptom-based management paradigm probably drives this. A biology-guided management paradigm is needed.
The new definition of extensively drug resistant tuberculosis endorsed by WHO poses some challenges that must be addressed in a coordinated fashion by researchers, TB control stakeholders and assay developers
#1Francisco Perez-Vizcaino (Complutense University of Madrid)H-Index: 51
#2Laura Moreno (Complutense University of Madrid)H-Index: 29
Last. José A. LorenteH-Index: 42
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#1Toby M. Maher (SC: University of Southern California)H-Index: 66
#2Kevin K. BrownH-Index: 109
Last. Rainer-Georg Goeldner (Boehringer Ingelheim)H-Index: 6
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The INBUILD trial investigated nintedanib versus placebo in patients with progressive fibrosing interstitial lung diseases (ILDs). We investigated decline in forced vital capacity (FVC) in subgroups based on the inclusion criteria for ILD progression.Subjects had a fibrosing ILD other than idiopathic pulmonary fibrosis and met these criteria for ILD progression within the 24 months before screening despite management deemed appropriate in clinical practice: Group A, relative decline in FVC ≥10% ...
Incidental pulmonary embolism in cancer patients remains a challenge. Since its prognosis appears to differ from symptomatic PE, optimal anticoagulation strategies, including distinct anticoagulant dosage and duration, need to be better elucidated.
#1Dave Singh (University of Manchester)H-Index: 75
Last. Elad H. KaufmanH-Index: 4
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#1Ingunn SkjørtenH-Index: 5
Last. Charlotte Bjork Ingul (Nord University)H-Index: 20
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RATIONALE: This study aimed to describe cardiopulmonary function during exercise 3 months after hospital discharge for COVID-19 and compare groups according to dyspnea and intensive care unit (ICU) stay. METHODS: Participants with COVID-19 discharged from five large Norwegian hospitals were consecutively invited to a multicentre, prospective cohort study. In total, 156 participants (mean age 56.2 years, 60 females) were examined with a cardiopulmonary exercise test (CPET) 3 months after di...
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#1John Stegmayr (Lund University)H-Index: 8
#2Darcy E. Wagner (Lund University)H-Index: 26
New techniques permit the use of multiple omics and advanced imaging technologies with human precision-cut lung slices (PCLS) to allow for more objective and comprehensive molecular analysis to bring PCLS closer to the era of precision medicine
#1P Jane McDowell ('QUB': Queen's University Belfast)H-Index: 2
#2John H. Stone (Harvard University)H-Index: 94
Last. Liam G Heaney ('QUB': Queen's University Belfast)H-Index: 58
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Reduction in glucocorticoid exposure is the primary benefit of new biologic treatments in severe asthma, but there is currently no evidence that reduction in glucocorticoid exposure corresponds to a proportionate reduction in associated toxicity. OBJECTIVES To use the validated Glucocorticoid Toxicity Index (GTI) to assess change in glucocorticoid toxicity after 12 months treatment with mepolizumab, and compare toxicity change to glucocorticoid reduction and change in patient reported outcome me...
#1Rupert Waudby-West (Dund.: University of Dundee)
#2Benjamin J Parcell (Ninewells Hospital)H-Index: 7
Last. Moneeza K. Siddiqui (Dund.: University of Dundee)H-Index: 6
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Lower Ct values from RT-PCR tests are associated with higher risk of mortality in SARS-CoV2 infections.Ct values null 30 [(95%CI: 1.28–3.76) adjusted for age,sex,comorbidities & hopsitalisation
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