Molecular Cancer Research
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#1Dinesh Kumar (NISER: National Institute of Science Education and Research)H-Index: 2
#2Saket Awadheshbhai Patel (NISER: National Institute of Science Education and Research)
Last. Manjusha Dixit (NISER: National Institute of Science Education and Research)H-Index: 15
view all 6 authors...
Anti-angiogenesis cancer therapies are facing setbacks due to side effects and resistance. Parallel targeting of multiple pathways can help in the development of more effective therapies. This requires the discovery of new molecules which can regulate multiple cellular processes. Our study has recently established the association of reduced IQGAP2 expression in breast cancer with EMT and poor prognosis of the patient. Existing literature indirectly suggests the role of IQGAP2 in angiogenesis whi...
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#1Benjamin Steinhart (Anschutz Medical Campus)
#2Kimberly R. Jordan (Anschutz Medical Campus)H-Index: 16
Last. Julia Wrobel (Anschutz Medical Campus)H-Index: 4
view all 7 authors...
Ovarian cancer is the deadliest gynecological malignancy. Multi-omics techniques have provided a platform for improved predictive modeling of therapy response and patient outcomes. While high-grade serous carcinoma (HGSOC) tumors are immunogenic and numerous studies have defined positive correlation to immune cell infiltration, immunotherapies in clinical trials have exhibited low efficacy rates. There is a significant need to better comprehend the role and composition of immune cells in mediati...
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#1Dongkook Min (Hackensack University Medical Center)
#2Jaemin Byun (Hackensack University Medical Center)
Last. Benjamin Tycko (UW: University of Washington)H-Index: 70
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Aberrant epigenetic transcriptional regulation is linked to metastasis, a primary cause of cancer-related death. Dissecting the epigenetic mechanisms controlling metastatic progression may uncover important insights to tumor biology and potential therapeutic targets. Here, we investigated the role of the SIN3A histone deacetylase 1 and 2 (SIN3A–HDAC1/2) complex in cancer metastasis. Using a mouse model of melanoma metastasis, we found that the SIN3A–HDAC1/2 transcription repressor complex silenc...
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#1Marieke Oldenbroek Burleson (University of Texas Health Science Center at San Antonio)
#2Janice Jianhong Deng (University of Texas Health Science Center at San Antonio)H-Index: 8
Last. P. Renee Yew (University of Texas Health Science Center at San Antonio)H-Index: 16
view all 19 authors...
Although the sonic hedgehog (SHH) signaling pathway has been implicated in promoting malignant phenotypes of prostate cancer, details on how it is activated and exerts its oncogenic role during prostate cancer development and progression is less clear. Here, we show that GLI3, a key SHH pathway effector, is transcriptionally upregulated during androgen deprivation and posttranslationally stabilized in prostate cancer cells by mutation of speckle-type POZ protein (SPOP). GLI3 is a substrate of SP...
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#1Yaling Hu (Nanjing Medical University)H-Index: 1
#2Yingdi Jiang (Nanjing Medical University)H-Index: 1
Last. Jian Zou (Nanjing Medical University)H-Index: 20
view all 11 authors...
Previous studies have demonstrated that glucocorticoid receptor β (GRβ) functions as an oncoprotein, regulating the malignant phenotypes and stem-like cell maintaining in human glioblastoma (GBM). Of the glucocorticoid receptor (GR) isoforms, GRβ and GRα are highly homologous, though the mechanism underlying the distinct functions of these two isoforms in GBM has not been clarified. Here by establishing a carboxyl-terminal (COOH-terminal) deletion mutant, we determined that GRβ can be ubiquitina...
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#1Yang Ge (Capital Medical University)H-Index: 9
#2Xiaona Fan (Beijing Chao-Yang Hospital)
Last. Jiannan Yao (Capital Medical University)H-Index: 6
view all 10 authors...
Cancer stem cell (CSC) marker doublecortin-like kinase 1 (DCLK1) contributes greatly to the malignancy of gastrointestinal cancers, and DCLK1-targeted agents have potential therapeutic value. However, the molecular pathways regulated by DCLK1-S (DCLK1 isoform 4), a shortened splice variant of DCLK1, still remain obscure. Here we found that the expression of DCLK1-S is significantly increased in human esophageal squamous cell carcinoma (ESCC) tissues and associated with malignant progression and p...
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#1Priyanka Sehgal (Children's Hospital of Philadelphia)
#2Claudia Lanauze (UPenn: University of Pennsylvania)H-Index: 1
Last. Andrei Thomas-Tikhonenko (Children's Hospital of Philadelphia)H-Index: 36
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Activation of Wnt signaling is among the earliest events in colon cancer development. It is achieved either via activating mutations in the CTNNB1 gene encoding β-catenin, the key transcription factor in the Wnt pathway, or most commonly by inactivating mutations affecting APC, a major β-catenin binding partner and negative regulator. However, our analysis of recent Pan Cancer Atlas data revealed that CTNNB1 mutations significantly co-occur with those affecting Wnt receptor complex components (e...
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#1Xi Chen (UMB: University of Maryland, Baltimore)
#2Gautam Adhikary (UMB: University of Maryland, Baltimore)H-Index: 20
Last. Richard L. EckertH-Index: 55
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Transglutaminase 2 (TG2) is a key epidermal squamous cell carcinoma cancer cell survival protein. null However, how TG2 maintains the aggressive cancer phenotype is not well understood. null The present studies show that TG2, which is highly expressed in epidermal cancer stem-like cells (ECS cells), maintains hepatocyte growth factor (HGF) signaling to drive an aggressive ECS cell cancer phenotype. null Inhibiting TG2 reduces MET tyrosine kinase receptor expression and activity and attenuates th...
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#1Tshering D. Lama-Sherpa (UAB: University of Alabama at Birmingham)H-Index: 1
#2Shamik Das (UAB: University of Alabama at Birmingham)H-Index: 15
Last. Lalita A. Shevde (UAB: University of Alabama at Birmingham)H-Index: 42
view all 9 authors...
Metastases account for the majority of mortalities related to breast cancer. The onset and sustained presence of hypoxia strongly correlates with increased incidence of metastasis and unfavorable prognosis in breast cancer patients. The Hedgehog (Hh) signaling pathway is dysregulated in breast cancer, and its abnormal activity enables tumor progression and metastasis. In addition to programming tumor cell behavior, Hh activity enables tumor cells to craft a metastasis-conducive microenvironment....
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#1Aditya Wirawan (Juntendo University)H-Index: 4
#2Ken Tajima (Juntendo University)H-Index: 15
Last. Tetsuhiko Asao (Juntendo University)H-Index: 7
view all 18 authors...
Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that has a low overall survival; however, no significant treatment advances have been made in the past 15 years. Large-scale molecular studies have identified a poor prognostic subset of MPM linked to the epithelial-mesenchymal transition (EMT) that may contribute toward resistance to chemotherapy, suggesting that EMT could be targeted to treat patients with MPM. Previously, we reported that histone modifiers regulating EMT could ...
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