European Journal of Pharmacology
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#1Lu Tang (CSU: Central South University)H-Index: 1
#2Yun-peng Li (Zhengzhou University)
Last. Yingli Mo (Hunan University)
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Abstract Reperfusion causes undesirable damage to the ischemic myocardium while restoring the blood flow. In this study, we evaluated the effects of dexpramipexole (DPX) on myocardial injury induced by ischemia/reperfusion (I/R) in-vivo and the hypoxia/reoxygenation (HR) in-vitro and examined the functional mechanisms of DPX. DPX protected cells against H/R-induced mitochondrial dysfunction and prevented H/R damage. Both myocardial infarct size and tissue damage due to I/R was reduced upon DPX t...
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#1Sarawoot Bunbupha (MSU: Mahasarakham University)H-Index: 9
#2Patoomporn Prasarttong (KKU: Khon Kaen University)H-Index: 2
Last. Poungrat Pakdeechote (KKU: Khon Kaen University)H-Index: 15
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Abstract In the present study, the therapeutic effects of imperatorin on metabolic and vascular alterations and possible underlying mechanisms were investigated in high-fat/high-fructose diet (HFFD)-fed rats. Male Sprague-Dawley rats were fed a high-fat diet plus 15% fructose in drinking water for 16 weeks. HFFD-fed rats were treated with imperatorin (15 or 30 mg/kg/day) for the last 4 weeks. In HFFD-fed rats, imperatorin significantly reduced obesity, hypertension, dyslipidemia, and insulin res...
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#1Honglin Zhou (CDUTCM: Chengdu University of Traditional Chinese Medicine)
#2Cheng Ma (CDUTCM: Chengdu University of Traditional Chinese Medicine)
Last. Yunxia Li (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 11
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Abstract With the improvement of people's living standards and the change of eating habits, non-alcoholic fatty liver disease (NAFLD) has gradually become one of the most common chronic liver diseases in the world. However, there are no effective drugs for the treatment of NAFLD. Therefore, it is urgent to find safe, efficient, and economical anti-NAFLD drugs. Compared with western medicines that possess fast lipid-lowering effect, traditional Chinese medicines (TCM) have attracted increasing at...
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#1Bertram PittH-Index: 97
#2Nadia R. Sutton (UM: University of Michigan)H-Index: 9
Last. Michael Holinstat (UM: University of Michigan)H-Index: 33
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There is a need for therapeutic approaches to prevent and mitigate the effects of Coronavirus Disease (2019) (COVID-19). The histone deacetylase (HDAC) inhibitor valproic acid, which has been available for the therapy of epilepsy for many years, is a drug that could be repurposed for patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This article will review the reasons to consider valproic acid as a potential therapeutic to prevent severe COVID-19. Valproic ac...
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#1Tetsuro Marunouchi (Tokyo University of Pharmacy and Life Sciences)H-Index: 8
#2Chiharu Nishiumi (Tokyo University of Pharmacy and Life Sciences)
Last. Kouichi Tanonaka (Tokyo University of Pharmacy and Life Sciences)H-Index: 26
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Abstract Necroptosis is a programmed form of necrotic cell death. Necroptosis is regulated by the necroptosis-regulating proteins including receptor-interacting protein (RIP) 1, RIP3, and mixed lineage kinase domain-like (MLKL), the activities of which are modulated by the molecular chaperone heat-shock protein (Hsp) 90. Presently, to clarify the relationship between Hsp90 and necroptotic pathway proteins, RIP1, RIP3, and MLKL in the development of heart failure, we examined the effects of Hsp90...
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#1Priyasha De (Manipal University)
#2Ishita Chakraborty (Manipal University)H-Index: 2
Last. Nirmal Mazumder (Manipal University)H-Index: 9
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Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the pandemic coronavirus disease 2019 (Covid-19) has claimed more than a million lives. Various in silico, in vitro, and in vivo studies are being conducted to understand the effect of SARS-CoV-2 on the cellular metabolism of humans and the various drugs and drug-targets that may be used. In this review, we discuss protein-protein interactions (PPIs) between viral and human proteins as well as viral tar...
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#1Hua Tu (CSU: Central South University)H-Index: 2
#2Yuan-Jing Zhou (CSU: Central South University)H-Index: 1
Last. Jun Peng (CSU: Central South University)H-Index: 25
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Abstract Necroptosis, ferroptosis and cyclophilin D (Cyp D)-dependent necrosis contribute to myocardial ischemia/reperfusion (I/R) injury, and ponatinib, deferoxamine and cyclosporine are reported to inhibit necroptosis, ferroptosis and Cyp D-dependent necrosis, respectively. This study aims to explore whether the any two combination between ponatinib, deferoxamine and cyclosporine exerts a better cardioprotective effect on I/R injury than single medicine does. The H9c2 cells were subjected to 1...
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#1Xiaoqing Wang (Lanzhou University)H-Index: 2
#2Yatao Liu (Lanzhou University)H-Index: 2
Last. Yufang Leng (Lanzhou University)H-Index: 3
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Abstract The objective of study was to investigate the inhibitory effect of sinomenine on neuropathic pain on dorsal root ganglia (DRG). The DRG cell line and spinal nerve ligation (SNL) model were used in this study. The effect of sinomenine on the cell viability was examined by MTT assay. The expression of p38 MAPK, NF-κB, c-fos, SP and TNF-α was detected by using immunofluorescence and immunohistochemistry assay. We also assessed the level of p-CaMKII, COX-2, p-CREB, IL-17A, TLR4 and IL-1β vi...
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#1Afra Rezagholizadeh (Tabriz University of Medical Sciences)
#2Sajad Khiali (Tabriz University of Medical Sciences)H-Index: 2
Last. Taher Entezari-Maleki (Tabriz University of Medical Sciences)H-Index: 8
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The coronavirus disease 2019 (COVID-19) pandemic has become a global health crisis. Considering the recent food and drug administration (FDA) approval of remdesivir as the first officially approved agent for COVID-19 treatment, we performed this systematic review and meta-analysis to evaluate the efficacy and safety of remdesivir administration in COVID-19 patients. A systematic literature search was done through MEDLINE, Google Scholar, Web of Science, Scopus, Science Direct, Cochrane Library, ...
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#1Tingting Lu (Anhui University of Chinese Medicine)
#2Jiangyan Cao (USTC: University of Science and Technology of China)
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Abstract As the critical driving force for chronic myeloid leukemia (CML), BCR gene fused ABL kinase has been extensively explored as a validated target of drug discovery. Although imatinib has achieved tremendous success as the first-line treatment for CML, the long-term application ultimately leads to resistance, primarily via various acquired mutations occurring in the BCR-ABL kinase. Although dasatinib and nilotinib have been approved as second-line therapies that could overcome some of thes...
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