European Journal of Pharmacology
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#1Fatemeh Zahedipour (MUMS: Mashhad University of Medical Sciences)H-Index: 5
#2Parvin Zamani (MUMS: Mashhad University of Medical Sciences)H-Index: 13
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 111
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Abstract null null Angiogenesis has a significant role in metastasis and progression of melanoma. Even small tumors may be susceptible to metastasis and hence lead to a worse outcome in patients with melanoma. One of the anti-angiogenic treatment approaches that is undergoing comprehensive study is specific immunotherapy. While tumor cells are challenging targets for immunotherapy due to their genetic instability and heterogeneity, endothelial cells (ECs) are genetically stable. Therefore, vacci...
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#1Shuxin Li (Hebei Normal University)H-Index: 1
#2Hongmin Zhang (Hebei Normal University)H-Index: 1
Last. Pengxiu Cao (Hebei Normal University)
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Pulmonary fibrosis (PF) is a chronic, progressive heterogeneous disease of lung tissues with poor lung function caused by scar tissue. Due to our limited understanding of its mechanism, there is currently no treatment strategy that can prevent the development of PF. In recent years, iron accumulation and mitochondrial damage have been reported to participate in PF, and drugs that reduce iron content and improve mitochondrial function have shown significant efficacy in animal experimental models....
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#1Victor Gustavo Balera Brito (UNESP: São Paulo State University)H-Index: 6
#2Mariana Sousa Patrocinio (UNESP: São Paulo State University)H-Index: 2
Last. Sandra Oliveira (UNESP: São Paulo State University)H-Index: 28
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Abstract null null Telmisartan (TELM) is an angiotensin II (Ang II) type 1 receptor (Agtr1) antagonist, with partial agonism for Pparg, and has been shown to affect bone metabolism. Therefore, the aim of this study was to investigate the effects of TELM in the in vitro osteogenic differentiation of bone marrow-derived mesenchymal stromal cells (BMSC) from spontaneously hypertensive rats (SHRs). BMSC were obtained from male SHR, and the osteogenic medium (OM) was added to the cells concomitantly ...
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#1Yulai FangH-Index: 2
#2Cong DuanH-Index: 1
Last. Yufeng Xia (CPU: China Pharmaceutical University)H-Index: 25
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#1Kun Zhao (NMU: Nanjing Medical University)H-Index: 4
#2Yukang Mao (NMU: Nanjing Medical University)H-Index: 1
Last. Yong Li (NMU: Nanjing Medical University)H-Index: 5
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Abstract null null The present study was designed to explore whether high sodium chloride (NaCl)-based diet (HSD) caused cardiac fibrosis regardless of blood pressure in Sprague-Dawley (SD) rats, and to further determine the effects and the underlying mechanisms of microRNA (miR)-210–5p on HSD-induced cardiac fibrosis in rats or NaCl-induced cardiac fibroblast activation in neonatal rat cardiac fibroblasts (NRCFs). The SD rats received 8% HSD, and NRCFs were treated with NaCl. The levels of coll...
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Abstract null null Drug repurposing or studying existing drugs for potential therapeutic utility in newer indications has been identified as an attractive option for treating a number of diseases. Various strategies of drug repurposing include serendipitous observation of drug's unexpected effects, directing the failed investigational drugs to new indications and currently adopted systematic approach to identify, screen and develop existing drug molecules for new off-label indications. Drug repu...
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#1Mayara Alves Amorim (UFPR: Federal University of Paraná)
#2Janiana Raíza Jentsch Matias de Oliveira (UFPR: Federal University of Paraná)H-Index: 2
Last. Eunice André (UFPR: Federal University of Paraná)H-Index: 21
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Abstract null null Dry cough has been reported in patients receiving statin therapy. However, the underlying mechanism or other possible alterations in the airways induced by statins remain unknown. Thus, the aim of this study was to evaluate whether simvastatin promotes alterations in airways, such as bronchoconstriction and plasma extravasation, as well as the mechanism involved in these events. Using methods to detect alterations in airway resistance and plasma extravasation, we demonstrated ...
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#1Cheng WangH-Index: 5
#2Cheng MaH-Index: 2
Last. Yunxia LiH-Index: 11
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#1Eman S. Said (Qassim University)H-Index: 2
#2Asmaa Mohammed Elsayed (FU: Fayoum University)H-Index: 1
Last. Rania H. Mahmoud (FU: Fayoum University)H-Index: 7
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Abstract null null Cognitive impairments such as dementia are considered the biggest challenges for public health. Benzodiazepines are often prescribed for treatment of anxiety disorder but they are associated with elevated risk of dementia. The present study has been designed to evaluate the neuroprotective effect of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice. Piracetam was used as an established nootropic agent. Mice were divided into 8 groups, group1; control ...
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#1Yoko Hirata (Gifu University)H-Index: 34
#2Masanari Motoyama (Gifu University)
Last. Yuji O. Kamatari (Gifu University)H-Index: 20
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Abstract null null Propolis, a compound produced by honeybees, has long been used in food and beverages to improve health and prevent diseases. We previously reported that the ethanol extracts of Brazilian green propolis and its constituents artepillin C, kaempferide, and kaempferol mitigate oxidative stress-induced cell death via oxytosis/ferroptosis. Here, we investigated the potential of Brazilian green propolis and its constituents to protect against endoplasmic reticulum stress in the mouse...
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