American Journal of Transplantation
Papers 9,312
1 page of 932 pages (9,312 results)
#1Dieter C. BroeringH-Index: 34
#2Mark Sturdevant (UWMC : University of Washington Medical Center)H-Index: 5
Last. Ahmed S. ZidanH-Index: 25
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Living donation in many countries is the main resource of organs. Healthy, volunteering individuals deserve the highest safety standards possible in addition to the least invasive technique to procure the organs. Since the introduction of living donor liver transplantation, many efforts have been made to minimize the surgical trauma inherent to living donor surgery. The journey started with a large Mercedes incision and evolved to a reverse L-shaped and small upper midline incisions before the i...
The optimal care for the transplant candidate is to receive a timely organ transplant. Effective organ donation is critical to this equation. Organ procurement organizations (OPOs) are responsible for: 1) ensuring organ donation occurs by identifying potential donors, obtaining consent, and executing organ allocation/distribution processes, and 2) that organs are recovered safely and efficiently to allow timely transplantation.
The question of whether transplant clinicians should mandate COVID-19 vaccination as a condition of transplant candidacy is complex. A vaccine mandate may be defensible on the grounds that transplant clinicians are obligated to ensure transplantation is conducted safely, and in a manner that entails the best use of a scarce public good. However, mandate proponents will inexorably predicate their arguments on contingent clinical judgments which meliorate rather than resolve core value disagreemen...
#2Marwan S Abouljoud (HFH: Henry Ford Hospital)H-Index: 26
Last. Philip F. Halloran (University of Alberta)H-Index: 106
view all 28 authors...
To extend previous molecular analyses of rejection in liver transplant biopsies in the INTERLIVER study ( #NCT03193151), the present study aimed to define the gene expression selective for parenchymal injury, fibrosis, and steatohepatitis. We analyzed genome-wide microarray measurements from 337 liver transplant biopsies from 13 centers. We examined expression of genes previously annotated as increased in injury and fibrosis using principal component analysis (PCA). PC1 reflect...
#1Brian Wayda (SU: Stanford University)H-Index: 7
#2Xingxing S. Cheng (SU: Stanford University)H-Index: 11
Last. Kiran K. Khush (SU: Stanford University)H-Index: 29
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Increasing rates of simultaneous heart-kidney (SHK) transplant in the United States exacerbate the overall shortage of deceased donor kidneys (DDK). Current allocation policy does not impose constraints on SHK eligibility, and how best to do so remains unknown. We apply a decision-analytic model to evaluate options for heart transplant (HT) candidates with comorbid kidney dysfunction. We compare SHK with a "Safety Net" strategy, in which DDK transplant is performed 6 months after HT, only if nat...
#1Christine M. Durand (Johns Hopkins Medicine)H-Index: 31
#2Sander Florman (Mount Sinai Hospital)H-Index: 45
view all 40 authors...
Liver transplantation (LT) from donors-with-HIV to recipients-with-HIV (HIV D+/R+) is permitted under the HOPE Act. There are only 3 international single case reports of HIV D+/R+ LT, each with limited follow-up. We performed a prospective multicenter pilot study comparing HIV D+/R+ to donors-without-HIV to recipients-with-HIV (HIV D-/R+) LT. We quantified patient survival, graft survival, rejection, serious adverse events (SAEs), HIV breakthrough, infections, and malignancies, using Cox and neg...
#1Arnaud Devresse (UCL: Université Catholique de Louvain)H-Index: 6
#2Renaud Lhommel (UCL: Université Catholique de Louvain)H-Index: 9
Last. Nada Kanaan (UCL: Université Catholique de Louvain)H-Index: 18
view all 5 authors...
Primary hyperoxaluria type 1 (PH1) is associated with hepatic overproduction of oxalate. Kidneys gradually become unable to eliminate excess oxalate, leading to systemic oxalosis (SO) with deposits in organs.1 When kidney transplantation (KT) becomes necessary, this oxalate load can lead to oxalate nephropathy recurrence. We report the potential interest of 18-FluoroDeoxy-Glucose Positron Emission Computed Tomography (18-FDG-PET/CT) as a tool to assess SO in PH1 patients. Signed informed consent...
#1Andre C. Kalil (UNMC: University of Nebraska Medical Center)H-Index: 51
#2Diana F. Florescu (UNMC: University of Nebraska Medical Center)H-Index: 25
Solid organ transplant (SOT) recipients carry a lifelong high risk of developing severe infections, including opportunistic, community, and hospital acquired infections. While major progress has been made in immunosuppressive drugs to prevent allograft rejection, the risk of infections remains always present because the continuing necessity of immunosuppressive drugs precludes a normal immune defense.
#1Freya Van Hulle (VUB: Vrije Universiteit Brussel)H-Index: 3
#2Kaat De Groot (VUB: Vrije Universiteit Brussel)H-Index: 1
Last. Daniel Jacobs-Tulleneers-Thevissen (VUB: Vrije Universiteit Brussel)H-Index: 11
view all 14 authors...
Intraportal (IP) islet cell transplants can restore metabolic control in type 1 diabetes patients, but limitations raise the need for establishing a functional beta cell mass (FBM) in a confined extrahepatic site. This study reports on function and composition of omental (OM) implants after placement of islet cell grafts with similar beta cell mass as in our IP-protocol (2-5.106 beta cells/kg body weight) on a scaffold. Four of seven C-peptide-negative recipients achieved low beta cell function ...
#1Hajime Matsushima (Nagasaki University)H-Index: 3
#2Miwa Morita-Nakagawa (Fukuoka Dental College)
Last. Koji Hashimoto (Cleveland Clinic Lerner Research Institute)H-Index: 24
view all 11 authors...
The importance of PD-1/PD-L1 interaction to alloimmune response is unknown in intestinal transplantation. We tested whether PD-L1 regulates allograft tissue injury in murine intestinal transplantation. PD-L1 expression was observed on the endothelium and immune cells in the intestinal allograft. Monoclonal antibody treatment against PD-L1 led to accelerated allograft tissue damage, characterized by severe cellular infiltrations, massive destruction of villi, and increased crypt apoptosis in the ...
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