American Journal of Transplantation
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7.34
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8642
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1 page of 900 pages (8,996 results)
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#1George H B Greenhall (NHSBT: NHS Blood and Transplant)
#2Ines Ushiro-Lumb (NHSBT: NHS Blood and Transplant)H-Index: 5
Last. Reza Motallebzadeh (Royal Free Hospital)
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Vaccine-induced thrombosis and thrombocytopenia (VITT) may follow immunisation with the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2. Autoantibodies to platelet factor 4 (PF4) may mediate VITT through antibody-dependent platelet activation, though the underlying etiology is uncertain. Anti-PF4 antibodies are also seen in heparin-induced thrombocytopenia, though most cases of VITT do not have prior heparin exposure. More than 20 million people in the United Kingdom (UK) have received the ChAdOx1 nC...
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#1Gaurav Gupta (VCU: Virginia Commonwealth University)H-Index: 16
#2Idris Yakubu (VCU: Virginia Commonwealth University)H-Index: 4
Last. M Shinbashi (VCU: Virginia Commonwealth University)
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Trials describing 4-12 week courses of direct-acting anti-viral drugs (DAAs) to treat hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant recipients (D+/R- transplants), may be limited in 'real-world' application by costs and delayed access to DAAs. We previously reported HCV transmission of 13% among D+/R- transplants with 2-4 day pangenotypic sofosbuvir/velpatasvir (SOF/VEL) peri-operative prophylaxis, where one patient with HCV transmission was a non-resp...
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#1Miranda So (UHN: University Health Network)H-Index: 8
#2Jonathan Hand (UQ: University of Queensland)H-Index: 8
Last. Dilek Ince (Roy J. and Lucille A. Carver College of Medicine)H-Index: 11
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Antimicrobial stewardship programs (ASPs) have made immense strides in optimizing antibiotic, antifungal, and antiviral use in clinical settings. However, while ASPs are required institutionally by regulatory agencies in the United States and Canada, they are not mandated for transplant centers or programs specifically. Despite the fact that solid-organ transplant recipients in particular are at increased risk of infections from multi-drug resistant organisms, due to host and donor factors and i...
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#1Nathan Osbun (UCLA: University of California, Los Angeles)H-Index: 4
#1Nathan Osbun (UCLA: University of California, Los Angeles)H-Index: 1
Last. Jeffrey L. Veale (UCLA: University of California, Los Angeles)H-Index: 17
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Nondirected kidney donors can initiate living donor chains that end to patients on the waitlist. We compared 749 National Kidney Registry (NKR) waitlist chain end transplants to other transplants from the NKR and the Scientific Registry of Transplant Recipients between February 2008 and September 2020. Compared to other NKR recipients, chain end recipients were more often older (53 vs. 52 years), black (32% vs. 15%), publicly insured (71% vs. 46%), and spent longer on dialysis (3.0 vs. 1.0 years...
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#1Ke ZhouH-Index: 1
#2Xiaona ChenH-Index: 7
Last. Penghong SongH-Index: 17
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Organ transplantation has become a mainstay of therapy for patients with end-stage organ diseases. However, long-term administration of immunosuppressive agents, a scheme for improving the survival of transplant recipients, has been compromised by severe side effects and posttransplantation complications. Therapeutic delivery targeting immune organs has the potential to address these unmet medical issues. Here, through screening of a small panel of mammalian target of rapamycin complex kinase in...
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On June 8th , Malinis et al, published their preliminary observations of the SARS-CoV-2 vaccine effectiveness in solid organ transplant recipients (SOTR) in the AJT (1). Their timely, real world results based on current practices are reassuring. Several studies have now shown 100% effectiveness of multiple SARS-CoV-2 vaccines in preventing hospitalization and death. As of May 17th , 2021, 860 of 123 million (0.0008%) who were fully vaccinated developed breakthrough infections that required hospi...
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#1C. A. te Velde-Keyzer (UG: University of Groningen)
#1Charlotte A Te Velde Keyzer (UG: University of Groningen)
Last. Martin H. de Borst (UG: University of Groningen)H-Index: 33
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We read with interest the article by Lees et al. The authors conclude that in their randomized controlled trial in kidney transplant recipients (KTRs), vitamin K supplementation (menadiol diphosphate 5 mg thrice-weekly) did not affect aortic distensibility or coronary artery calcium score. Although the authors deserve credit for their 'Viktory' of completing this trial, and notwithstanding the relevance to publish null trial results, we question if their conclusions apply to all KTRs.
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#1Daan Kremer (UMCG: University Medical Center Groningen)H-Index: 4
#2Tobias T PietersH-Index: 2
Last. Bas W.M. van BalkomH-Index: 29
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Kidney transplant recipients (KTR) may be at increased risk of adverse COVID-19 outcomes, due to prevalent comorbidities and immunosuppressed status. Given the global differences in COVID-19 policies and treatments, robust assessment of all evidence is necessary to evaluate the clinical course of COVID-19 in KTR. Studies on mortality and acute kidney injury (AKI) in KTR in the World Health Organization COVID-19 database were systematically reviewed. We selected studies published between March 20...
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#1David J. Taber (MUSC: Medical University of South Carolina)H-Index: 24
#2James N. Fleming (MUSC: Medical University of South Carolina)H-Index: 12
Last. Mulugeta Gebregziabher (MUSC: Medical University of South Carolina)H-Index: 32
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This was an economic analysis of a 12-month, parallel arm, randomized controlled trial in adult kidney recipients 6 to 36 months posttransplant (NCT03247322). All participants received usual posttransplant care, while the intervention arm received supplemental clinical pharmacist-led medication therapy monitoring and management, via a smartphone-enabled mHealth app, integrated with risk-based televisits. Hospitalization charges were captured from the study institution accounts payable and non-st...
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