AIM Gastrointestinal (GI) symptoms are often reported by CF patients. Despite a proven relation to exocrine pancreatic insufficiency (PI), it remains unclear whether GI symptoms are related to the timing of pancreatic enzyme replacement therapy (PERT). Whereas most international recommendations suggest administration of PERT at the beginning of meals, it has not been studied whether such a proceeding is associated with lower burden of symptoms. METHODS Thirty CF patients aged 0-17 years of age w...
Last. Ilari Kuitunen(University of Eastern Finland)H-Index: 3
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Aim null Nationwide lockdowns and social restrictions during the COVID-19 pandemic have reduced childhood infections. We assessed how many items of systemic antibiotics and asthma medicines were dispensed to children aged-0-12 years in Finland before and during the pandemic and analysed the reimbursement costs. null Methods null The data came from the national Finnish register of reimbursable prescriptions, which is maintained by the country's Social Insurance Institution. It included all prescr...
AIM To investigate neurodevelopmental outcome in 12-year-old children born very preterm in relation to perinatal, neonatal and socioeconomic variables. To examine whether previously described positive effects of antenatal steroids on cognition persist at 12 years. METHODS Prospective cohort, 78 children with gestational ages 22.7-31.9 weeks, born in 2004-2007 and examined at 12 years of age with cognitive, motor and visual motor integration tasks and compared to an age-matched control group (n =...
Last. Rachel Rosen(Boston Children's Hospital)H-Index: 24
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Many infants with fussiness or spitting-up are prescribed acid suppression therapy with proton pump inhibitors (PPIs) and H2 antagonists (H2RAs) despite data suggesting these therapies do not improve symptoms over placebo. Furthermore, there are risks with acid suppression treatment, including increasing rates of gastroenteritis, pneumonia and necrotizing enterocolitis.
AIM To test the two prevailing hypotheses regarding the aetiology of infant retinal haemorrhage: (a) traction forces exerted by the lens and/or corpus vitreum on the retina during infant shaking or (b) retinal vessel leakage secondary to intracranial pathology and raised intracranial pressure. METHODS Comparison of medical findings and reported type of trauma in infants investigated for suspected physical abuse with presence (n = 29) or non-presence of retinal haemorrhage (RH) (n = 119). RESULTS...
Multisystem inflammatory syndrome (MIS) in children (MIS-C) is a complication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, while myocarditis is a rare adverse effect to messenger ribonucleic acid (mRNA) SARS-CoV-2 vaccines, especially in males aged 12-17 years.
Aim null Vaccines are vital to ending the COVID-19 pandemic and we reviewed the data on vaccinating children, and including them in clinical trials, as most of the activity has focused on adults. null Methods null English and Chinese databases, including PubMed, Elsevier Scopus, Web of Science, CNKI and CQVIP were searched, along with websites such as the World Health Organization and the University of Oxford. null Results null We identified 44 papers and 16 news items about vaccinating children...
Austria partly spared its healthcare system from the catastrophic effects of the COVID-19 pandemic with an early lockdown. This led to a marked decrease in visits to the paediatric emergency department (PED) at the Medical University of Innsbruck. The PED is the central point of contact for patients under the age of 18 with any health concerns, except trauma. Approximately 18,700 patients visit the PED per year and 17.6% are admitted to the hospital.
Nasal high flow (HF) therapy has rapidly become a popular mode of respiratory support in the neonatal unit due to its ease of use and excellent tolerance. In recent years, clinical evidence to refine its role has accumulated, although there has been limited focus on the most extremely preterm infants. This survey aimed to assess HF practice in extremely preterm infants in the United Kingdom (UK) in line with current evidence and to identify areas for development.
Aim null Several countries, such as Norway and Sweden, have not implemented universal varicella vaccination. We present data for Norway and Sweden that were generated by a paediatric multi-country Phase III study over a 10-year period. This assessed the efficacy, antibody persistence and safety of two varicella vaccines containing the same Oka-strain. null Methods null This was an observer-blind, controlled trial conducted in 10 European countries. Children aged 12-22 months (n=5803) were random...