Muscle & Nerve
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#1Takahiro Asano (Mie University)H-Index: 1
#2Masaya Tsujii (Mie University)H-Index: 12
Last. Akihiro Sudo (Mie University)H-Index: 44
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INTRODUCTION/AIMS Obesity is a factor contributing to suboptimal improvement of motor function in peripheral nerve disorders. In this study we aimed to evaluate the skeletal muscles during denervation and reinnervation after nerve crush injury in leptin-deficient (ob/ob) mice. METHODS Experiments were performed on the skeletal muscles of the hindlimbs in 20 male ob/ob mice and controls. Characteristics of the gastrocnemius muscles were evaluated by histological analysis, immunohistological analy...
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#1Mazen Alamr (Mayo Clinic)
#2Margherita Milone (Mayo Clinic)H-Index: 40
Last. Teerin Liewluck (Mayo Clinic)H-Index: 17
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INTRODUCTION/AIMS Intracellular congophilic inclusions within muscle fibers, although nonspecific, are one of the pathological hallmarks of sporadic inclusion body myositis (sIBM). Extracellular amyloid deposits in muscle, on the other hand, are the canonical findings of amyloid myopathies, which occur with or without systemic amyloidosis. METHODS We reviewed the muscle biopsy database (1998-2020) to identify sIBM patients with extracellular amyloid deposits. Clinical and laboratory data were re...
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#1Anne Louise Oaklander (Harvard University)H-Index: 36
#2Trudy van Houten (Harvard University)H-Index: 1
Last. A. Sassan Sabouri (Harvard University)H-Index: 3
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INTRODUCTION Isolated injuries to the lateral cutaneous nerve (LCNC) branch of the common peroneal nerve can cause obscure chronic posterolateral knee and upper calf pain and sensory symptoms. Routine examination and electrodiagnostic testing do not detect them because the LCNC has no motor distribution and it is not interrogated by typical peroneal nerve conduction study. There are only about 10 prior cases-thus scant physician awareness-so most LCNC injuries remain misdiagnosed or undiagnosed,...
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#1Tiffany Pike-Lee (Cleveland Clinic)H-Index: 1
#2Dana Higginbotham (Cleveland Clinic)
Last. Yuebing Li (Cleveland Clinic)H-Index: 13
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Introduction/aims null Ulnar nerve repetitive nerve stimulation (RNS) has been traditionally used in the electrophysiological evaluation of myasthenia gravis (MG). However, its low diagnostic sensitivity remains a limitation. Existing data may suggest that median nerve RNS outperforms that of the ulnar nerve, but a direct comparison is currently lacking. The aim of this study was to directly compare the diagnostic yields between the median versus ulnar nerve RNS in patients with generalized MG. ...
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#1Elizabeth Kichula (Children's Hospital of Philadelphia)H-Index: 5
#2Crystal M Proud (Boston Children's Hospital)
Last. Hugh J. McMillan (Children's Hospital of Eastern Ontario)H-Index: 22
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Spinal muscular atrophy (SMA) is an autosomal recessive, neurodegenerative disease caused by biallelic mutations in the survival motor neuron 1 (SMN1) gene. SMA is characterized by motor neuron degeneration resulting in progressive muscle atrophy and weakness. Prior to the emergence of disease-modifying therapies, children with the most severe form of SMA never achieved the ability to sit independently. Only 8% survived beyond 20 months of age without permanent ventilator support. One such thera...
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#1Thierry GendreH-Index: 2
Last. Alain CréangeH-Index: 31
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#1Fiona Hawke (University of Newcastle)H-Index: 10
#2Marnee J. McKay (RMIT: RMIT University)H-Index: 9
Last. Joshua Burns (Children's Hospital at Westmead)H-Index: 36
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INTRODUCTION/AIMS We explored correlates of night-time and exercise-associated lower limb cramps in participants of the 1000 Norms Project. METHODS A volunteer community sample of healthy people aged ≥18 y underwent assessment of motor function and physical performance, and were questioned about muscle cramps in the previous 3 mo. RESULTS Of 491 (221 female) participants age 18-101 y (mean: 59.12; SD: 18.03), about 1 in 3 experienced night-time lower limb cramps, and about 1 in 4 experienced exe...
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#1Han-Ding Mao (Chinese PLA General Hospital)H-Index: 1
#2Xin Li (Chinese PLA General Hospital)
Last. Qing Song (Chinese PLA General Hospital)H-Index: 1
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INTRODUCTION/AIMS Exertional rhabdomyolysis (ER) often occurs during prolonged intense exercise in hot environments, posing a threat to the health of military personnel. In this study we aimed to investigate possible risk factors for ER and provide further empirical data for prevention and clinical treatment strategies. METHODS A retrospective investigation of 116 concurrent ER cases was conducted. Conditional logistic regression analyses were performed to assess the association between each pot...
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#1Stefan Nicolau (Mayo Clinic)H-Index: 5
#2Margherita Milone (Mayo Clinic)H-Index: 40
Last. Teerin Liewluck (Mayo Clinic)H-Index: 17
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Despite recent advances in the understanding of inherited muscle and neuromuscular junction diseases, as well as the advent of a wide range of genetic tests, patients continue to face delays in diagnosis of sometimes treatable disorders. These guidelines outline an approach to genetic testing in such disorders. Initially, a patient's phenotype is evaluated to identify myopathies requiring directed testing, including myotonic dystrophies, facioscapulohumeral muscular dystrophy, oculopharyngeal mu...
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#1K. H. Vincent Lau (BU: Boston University)H-Index: 5
#2Michelle Kaku (BU: Boston University)H-Index: 9
Last. Peter Siao (BU: Boston University)H-Index: 1
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Abstract Introduction The initial surge of the Coronavirus Disease 2019 (COVID-19) pandemic in early 2020 led to widespread cancelation of elective medical procedures in the United States, including non-urgent outpatient and inpatient electrodiagnostic (EDX) studies null As certain regions later saw a downtrend in daily new cases, EDX laboratories have reopened under the guidance of the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) null In our reopening experience gu...
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