Seminars in Fetal & Neonatal Medicine
IF
3.93
Papers
1,120
Papers 1,103
1 page of 111 pages (1,103 results)
#1Jessica L. Wisnowski (CHLA: Children's Hospital of Los Angeles)H-Index: 14
#2Pia Wintermark (MUHC: McGill University Health Centre)H-Index: 3
Last. Vann Chau (University of Toronto)H-Index: 19
view all 9 authors...
Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few published guidelines on neuroimaging for neonates with NE. This review outlines the primary patterns of brain injury associated with hypoxic-ischemic injury in neonates with NE and their frequency, associated neuropathological features, and risk factors. In addition, it provides an overview of neuroimaging methods, includ...
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#1Pia Wintermark (Montreal Children's Hospital)H-Index: 20
#2Khorshid Mohammad (UoC: University of Calgary)H-Index: 9
Last. Sonia L. Bonifacio (SU: Stanford University)H-Index: 25
view all 3 authors...
Neonates with neonatal encephalopathy (NE) often present with multi-organ dysfunction that requires multidisciplinary specialized management. Care of the neonate with NE is thus complex with interaction between the brain and various organ systems. Illness severity during the first days of birth, and not only during the initial hypoxia-ischemia event, is a significant predictor of adverse outcomes in neonates with NE treated with therapeutic hypothermia (TH). We thus propose a care practice bundl...
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#1Christian F. Poets (University of Tübingen)H-Index: 43
#2Véronique Abadie (University of Paris)H-Index: 14
Last. Cornelia Wiechers (University of Tübingen)H-Index: 8
view all 9 authors...
Abstract null null Treatment of infants with craniofacial malformations, e.g. Robin sequence, is characterized by considerable heterogeneity and a lack of randomized trials to identify an optimal approach. We propose to establish an international register using a common minimal dataset that will better allow for a comparison between key determinants and outcomes in these patients. In infants, this should include an assessment of mandibular micrognathia, glossoptosis, upper airway obstruction, we...
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#2Alexa Craig (Tufts University)H-Index: 1
view all 4 authors...
Abstract null null Neonates and families face challenges in hypothermic therapy, including trauma to parents, extreme emotions, and unfamiliarity with the medical system. Communication is an essential element to supporting parents while their children are in the NICU, and beyond, building the foundation for the ongoing relationship the family has with the medical system. Significant consideration needs to be given to the critical element of integrating the family into the care of a baby being tr...
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#1A.G. Sandoval Karamian (CHOP: Children's Hospital of Philadelphia)H-Index: 1
#2Saadet Mercimek-Andrews (University of Alberta)H-Index: 1
Last. Courtney J. Wusthoff (SU: Stanford University)H-Index: 31
view all 8 authors...
Neonatal encephalopathy (NE) describes the clinical syndrome of a newborn with abnormal brain function that may result from a variety of etiologies. HIE should be distinguished from neonatal encephalopathy due to other causes using data gathered from the history, physical and neurological exam, and further investigations. Identifying the underlying cause of encephalopathy has important treatment implications. This review outlines conditions that cause NE and may be mistaken for HIE, along with t...
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#1Danielle R. Rios (UI: University of Iowa)H-Index: 2
#2Anie Lapointe (University of Montreal)H-Index: 6
Last. Regan E Giesinger (UI: University of Iowa)H-Index: 9
view all 9 authors...
Abstract null null Neonatal encephalopathy due to a hypoxic-ischemic event is commonly associated with cardiac dysfunction and acute pulmonary hypertension; both therapeutic hypothermia and rewarming modify loading conditions and blood flow. The pathophysiological contributors to disease are complex with a high degree of clinical overlap and traditional bedside measures used to assess circulatory adequacy have multiple confounders. Comprehensive, quantitative echocardiography may be used to deli...
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#2Janette Mailo (Glenrose Rehabilitation Hospital)H-Index: 1
Last. Taeun Chang (GWU: George Washington University)H-Index: 26
view all 10 authors...
Neonatal encephalopathy (NE) is the most common etiology of acute neonatal seizures - about half of neonates treated with therapeutic hypothermia for NE have EEG-confirmed seizures. These seizures are best identified with continuous EEG monitoring, as clinical diagnosis leads to under-diagnosis of subclinical seizures and over-treatment of events that are not seizures. High seizure burden, especially status epilepticus, is thought to augment brain injury. Treatment, therefore, is aimed at minimi...
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#1Penn Aa (CU: Columbia University)H-Index: 1
#2Pia Wintermark (Montreal Children's Hospital)H-Index: 20
Last. Karin B. Nelson (NIH: National Institutes of Health)H-Index: 54
view all 7 authors...
Abstract null null Placental assessment, although currently underused, can inform our understanding of the etiology and timing of Neonatal Encephalopathy (NE). We review our current understanding of the links between placental dysfunction and NE and how this information may inform clinical decisions, now and in the future, emphasizing the four major placental lesions associated with NE. In addition, we discuss maternal and fetal factors that are hypothesized to contribute to specific placental p...
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#1Lina F. Chalak (The University of Texas Southwestern Medical Center)H-Index: 24
#2Lena Hellström-Westas (Uppsala University Hospital)H-Index: 43
view all 9 authors...
Several bedside and laboratory neuromonitoring tools are currently used in neonatal encephalopathy (NE) to assess 1) brain function [amplitude-integrated electroencephalogram (aEEG) and EEG], 2) cerebral oxygenation delivery and consumption [near-infrared spectroscopy (NIRS)] and 3) blood and cerebrospinal fluid biomarkers. The aim of the review is to provide the role of neuromonitoring in understanding the development of brain injury in these newborns and better predict their long-term outcome....
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#1Neil Marlow (UCL: University College London)H-Index: 66
#2Seetha Shankaran (WSU: Wayne State University)H-Index: 76
Last. Christopher D. Smyser (WUSTL: Washington University in St. Louis)H-Index: 27
view all 5 authors...
In randomized trials, therapeutic hypothermia (TH) is associated with reduced prevalence of the composite outcome mortality or neurodevelopmental morbidity in infants with neonatal encephalopathy (NE). Following systematic review, the reduction in prevalence of both mortality and infant neuromorbidity is clear. Among three trials reporting school age outcomes, the effects of NE and TH suggest that such benefit persists into middle childhood, but none of the major trials were powered to detect di...
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