Movement Disorders
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#1Annette Janzen (University of Marburg)H-Index: 10
#2Rosalie Vered Kogan (UMCG: University Medical Center Groningen)H-Index: 4
Last. Wolfgang H. Oertel (University of Marburg)H-Index: 126
view all 12 authors...
Background null Isolated rapid eye movement sleep behavior disorder (iRBD) is prodromal for α-synucleinopathies. null Objective null The aim of this study was to determine whether pathological cardiac [123 I]meta-iodobenzylguanidine scintigraphy ([123 I]MIBG) is associated with progression of [18 F]fluorodeoxyglucose-positron emission tomography-based Parkinson's disease (PD)-related brain pattern (PDRP) expression in iRBD. null Methods null Seventeen subjects with iRBD underwent [18 F]fluorodeo...
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#2C. Tarrano (Allen Institute for Brain Science)
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#1Yingying Zhang (Sichuan University)H-Index: 4
#2Weixi Xiong (Sichuan University)H-Index: 10
Last. Dong Zhou (Sichuan University)H-Index: 52
view all 5 authors...
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#1Dallah Yoo (Kyung Hee University)H-Index: 7
#2Wonjae Lee (New Generation University College)H-Index: 4
Last. Tae-Beom Ahn (Kyung Hee University)H-Index: 17
view all 10 authors...
Background null Tropomyosin-receptor kinase fused gene (TFG) functions as a regulator of intracellular protein packaging and trafficking at the endoplasmic reticulum exit sites. TFG has recently been proposed as a cause of multisystem proteinopathy. null Objectives null Here, we describe a Korean family presenting with Parkinson's disease or amyotrophic lateral sclerosis caused by a novel variant of TFG (c.1148 G > A, p.Arg383His). null Methods null We collected clinical, genetic, dopamine trans...
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#1Chun Chen (Newcastle University)H-Index: 4
#2Emily Mossman (Newcastle University)
Last. Amy K. Reeve (Newcastle University)H-Index: 25
view all 11 authors...
Background null Mitochondrial dysfunction within neurons, particularly those of the substantia nigra, has been well characterized in Parkinson's disease and is considered to be related to the pathogenesis of this disorder. Dysfunction within this important organelle has been suggested to impair neuronal communication and survival; however, the reliance of astrocytes on mitochondria and the impact of their dysfunction on this essential cell type are less well characterized. null Objective null Th...
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#1Carlos Cosentino (UNMSM: National University of San Marcos)H-Index: 10
#2Luis TorresH-Index: 11
view all 7 authors...
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#1Annemarie VogelH-Index: 2
#2Inga ClausH-Index: 8
Last. Tobias WarneckeH-Index: 32
view all 10 authors...
BACKGROUND Dysphagia is a major clinical concern in multiple system atrophy (MSA). A detailed evaluation of its major endoscopic features compared with Parkinson's disease (PD) is lacking. OBJECTIVE This study systematically assessed dysphagia in MSA compared with PD and correlated subjective dysphagia to objective endoscopic findings. METHODS Fifty-seven patients with MSA (median, 64 [interquartile range (IQR): 59-71] years; 35 women) underwent flexible endoscopic evaluation of swallowing using...
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#1Emma Louise Lane (Cardiff University)H-Index: 16
#2David J. Harrison (Cardiff University)H-Index: 74
Last. Mariah Jillian Lelos (Cardiff University)H-Index: 10
view all 6 authors...
Background null The risk of graft-induced dyskinesias (GIDs) presents a major challenge in progressing cell transplantation as a therapy for Parkinson's disease. Current theories implicate the presence of grafted serotonin neurons, hotspots of dopamine release, neuroinflammation and established levodopa-induced dyskinesia. null Objective null To elucidate the mechanisms of GIDs. null Methods null Neonatally desensitized, dopamine denervated rats received intrastriatal grafts of human embryonic s...
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#1D. James Surmeier (NU: Northwestern University)H-Index: 96
Last. Richard K. WyseH-Index: 9
view all 7 authors...
Background null Recent examination of the STEADY-PD III isradipine clinical trial data concluded that early-stage Parkinson's disease (PD) participants who had longer exposure to isradipine had a significant delay in their need for symptomatic medication, as well as a lower medication burden at the end of the trial. These findings suggest that greater exposure to isradipine might slow disease progression. null Objectives null To test this hypothesis, the data from the STEADY-PD II isradipine cli...
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#1Daniel P. Eisenberg (NIH: National Institutes of Health)H-Index: 12
#2Grisel Lopez (NIH: National Institutes of Health)H-Index: 27
Last. Ellen Sidransky (NIH: National Institutes of Health)H-Index: 68
view all 5 authors...
Background null Mutations in GBA1 are a common genetic risk factor for parkinsonism; however, penetrance is incomplete, and biomarkers of future progression to parkinsonism are needed. Both nigral sonography and striatal [18 F]-FDOPA PET assay dopamine system health, but their utility and coherence in this context are unclear. null Objective null The aim of this study is to evaluate the utility and coherence of these modalities in GBA1-associated parkinsonism. null Methods null A total of 34 pat...
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