CNS Drugs
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#1Tao Xu (CQMU: Chongqing Medical University)H-Index: 10
#2You Wang (CQMU: Chongqing Medical University)H-Index: 1
Last. Yangmei Chen (CQMU: Chongqing Medical University)H-Index: 5
view all 4 authors...
BACKGROUND Several real-world observational studies have investigated the association between statin treatment and outcomes of cardioembolic stroke. However, substantial uncertainties remain about this association. OBJECTIVE We aimed to perform a systematic review and meta-analysis to determine the effect of statin treatment on the outcomes of cardioembolic stroke. METHODS We systematically searched the PubMed and Embase databases for relevant clinical studies. Pooled relative risks (RRs) and 95...
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#1Erica Bell (USYD: University of Sydney)H-Index: 4
#2Phil Boyce (USYD: University of Sydney)
Last. Gin S Malhi (USYD: University of Sydney)H-Index: 71
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Feeling irritable is a common experience, both in health and disease. In the context of psychiatric illnesses, it is a transdiagnostic phenomenon that features across all ages, and often causes significant distress and impairment. In mood disorders, irritability is near ubiquitous and plays a central role in diagnosis and yet, despite its prevalence, it remains poorly understood. A neurobiological model of irritability posits that, in children and adolescents, it is consequent upon deficits in r...
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#1Robert L. FindlingH-Index: 78
#2Shawn A. CandlerH-Index: 2
Last. Jeffrey H. Newcorn (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 72
view all 8 authors...
Viloxazine has a long history of clinical use in Europe as an antidepressant, and has recently been repurposed into an extended-release form for the treatment of attention-deficit/hyperactivity disorder in the USA. An immediate-release formulation was approved for the treatment of depression in the UK in 1974, and was subsequently marketed there and in several European countries for 30 years with no major safety concerns. In contrast to first-generation antidepressants (e.g., tricyclic antidepre...
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#1Christina Sun‐Edelstein (St. Vincent's Health System)H-Index: 1
#2Alan M. Rapoport (UCLA: University of California, Los Angeles)H-Index: 43
Last. Anan Srikiatkhachorn (King Mongkut's Institute of Technology Ladkrabang)H-Index: 3
view all 4 authors...
Medication overuse headache (MOH), the development or worsening of chronic headache resulting from frequent and excessive intake of medications used for acute treatment of headache, is a common secondary headache disorder and is associated with significant personal and societal burdens. The plausible physiologic mechanism is that chronic exposure to acute care migraine treatment leads to suppression of endogenous antinociceptive systems, consequently facilitating the trigeminal nociceptive proce...
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#1Roberta RobertiH-Index: 3
#2Carmen De CaroH-Index: 12
Last. Emilio RussoH-Index: 37
view all 6 authors...
Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be increased to a maximum of 400 mg/day based on clinical response. Although the high rate of seizure freedom observed in randomized, placebo-controlled clinical trials has resulted in exciting expectations, further clinical studies are needed to better d...
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#1Colin J. Mahoney (USYD: University of Sydney)H-Index: 19
#2Rebekah M. Ahmed (USYD: University of Sydney)H-Index: 23
Last. Matthew C. Kiernan (USYD: University of Sydney)H-Index: 69
view all 8 authors...
Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease typically presenting with bulbar or limb weakness. There is increasing evidence that amyotrophic lateral sclerosis is a multisystem disease with early and frequent impacts on cognition, behaviour, sleep, pain and fatigue. Dysfunction of normal physiological and metabolic processes also appears common. Evidence from pre-symptomatic studies and large epidemiological cohorts examining risk factors for the future deve...
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#1Juan Song (Zhengzhou University)H-Index: 7
#2Yong Wang (Zhengzhou University)H-Index: 3
Last. Changlian Zhu (KI: Karolinska Institutet)H-Index: 45
view all 14 authors...
BACKGROUND Intraventricular hemorrhage (IVH) is a common complication in preterm infants that has poor outcomes, especially in severe cases, and there are currently no widely accepted effective treatments. Erythropoietin has been shown to be neuroprotective in neonatal brain injury. OBJECTIVE The objective of this study was to evaluate the protective effect of repeated low-dose recombinant human erythropoietin (rhEPO) in preterm infants with IVH. METHODS This was a single-blinded prospective ran...
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#1Dee Lin (Janssen Pharmaceutica)
#2Philippe Thompson-Leduc (AG: Analysis Group)H-Index: 5
Last. Patrick Lefebvre (AG: Analysis Group)H-Index: 30
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Background Long-acting injectable (LAI) antipsychotics, compared with oral antipsychotics (OA), have been found to significantly improve patient outcomes, including reduced hospitalizations and emergency room (ER) admissions and increased medication adherence among adult patients with schizophrenia. In turn, the clinical benefits achieved may translate into lower economic burden. Real-world evidence of the comparative effectiveness of LAI is needed to understand the potential benefits of LAI out...
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#1Ioline D. Henter (NIH: National Institutes of Health)H-Index: 27
#2Lawrence Park (NIH: National Institutes of Health)H-Index: 18
Last. Carlos A. Zarate (NIH: National Institutes of Health)H-Index: 81
view all 3 authors...
The efficacy of standard antidepressants is limited for many patients with mood disorders such as major depressive disorder (MDD) and bipolar depression, underscoring the urgent need to develop novel therapeutics. Both clinical and preclinical studies have implicated glutamatergic system dysfunction in the pathophysiology of mood disorders. In particular, rapid reductions in depressive symptoms have been observed in response to subanesthetic doses of the glutamatergic modulator racemic (R,S)-ket...
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#1Frank M.C. Besag (UCL: University College London)H-Index: 20
#2Michael J. Vasey (UCL: University College London)H-Index: 4
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Psychotropic medication treatment can cause elevated serum prolactin levels and hyperprolactinaemia (HPRL). Reports have suggested that aripiprazole may decrease elevated prolactin. The aim of this review was to assess evidence for the efficacy of adjunct aripiprazole in the treatment of psychotropic-induced HPRL. PubMed and Google Scholar were searched to identify randomised placebo-controlled trials (RCTs) of adjunct aripiprazole in patients with HPRL attributed to primary psychotropic medicat...
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