Pharmacoepidemiology and Drug Safety
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#1Hayato Yamana (UT: University of Tokyo)H-Index: 15
#2Asuka Tsuchiya (UT: University of Tokyo)H-Index: 7
Last. Hideo Yasunaga (UT: University of Tokyo)H-Index: 55
view all 10 authors...
Purpose null Validating outcome measures is a prerequisite for using administrative databases for comparative effectiveness research. Although the Japanese Diagnosis Procedure Combination database is widely used in surgical studies, the outcome measure for postsurgical infection has not been validated. We developed a model to identify postsurgical infections using the routinely-collected Diagnosis Procedure Combination data. null Methods null We retrospectively identified inpatients who underwen...
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#1Liliya Sinyavskaya (University of Montreal)H-Index: 3
#2Christel Renoux (Jewish General Hospital)H-Index: 25
Last. Madeleine Durand (University of Montreal)H-Index: 18
view all 3 authors...
PURPOSE In clinical practice, warfarin therapy requires frequent dose adjustments. In pharmacy claims, the days supplied value may not reflect the true duration of warfarin dispensation. This may affect the measures of association comparing the safety of direct oral anticoagulants (DOACs) versus warfarin. METHODS Using Quebec healthcare administrative databases, we formed a cohort of 55 230 patients newly treated with oral anticoagulants between 2010 and 2016. The duration of dispensations was d...
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#1Rohan Mital (CDC: Centers for Disease Control and Prevention)
#2Maribeth C. Lovegrove (CDC: Centers for Disease Control and Prevention)H-Index: 15
Last. Daniel S. Budnitz (CDC: Centers for Disease Control and Prevention)H-Index: 31
view all 7 authors...
BACKGROUND AND PURPOSE Characterization of emergency department (ED) visits for acute harms related to use of over-the-counter cough and cold medications (CCMs) by patient demographics, intent of CCM use, concurrent substance use, and clinical manifestations can help guide prevention of medication harms. METHODS Public health surveillance data from the National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance project were used to estimate numbers and population r...
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#1Jun Gong (PKU: Peking University)
#2Lingyue Ma (PKU: Peking University)H-Index: 8
Last. Yimin Cui (PKU: Peking University)H-Index: 20
view all 8 authors...
INTRODUCTION Nonsteroidal anti-inflammatory drugs (NSAIDs) are regarded as nephrotoxins. Children commonly use NSAIDs and are susceptible to nephropathy, but the relationship between acute kidney injury (AKI) and use of NSAIDs is not well examined yet. OBJECTIVE To evaluate the relationship between AKI and use of NSAIDs in hospitalized pediatric patients who are susceptible to nephropathy. METHODS We conducted this systematic review and meta-analysis of observational studies by searching PubMed,...
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#1Emmanuelle Gosselin (Université Laval)H-Index: 1
#2Marc Simard (Université Laval)H-Index: 35
Last. Caroline Sirois (Université Laval)H-Index: 15
view all 4 authors...
BACKGROUND Benzodiazepines and other hypnotic alternatives are associated with increased risks of adverse events. Heightened awareness of risks may have changed prescribing habits over the years. However, these trends are not fully described, especially in vulnerable people such as multimorbid older adults. OBJECTIVE We aimed to describe the annual prevalence of benzodiazepine and other hypnotic use in relation to multimorbidity among older adults in the province of Quebec, Canada, from 2000 to ...
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#1Anton Pottegård (SDU: University of Southern Denmark)H-Index: 37
#2Lucas Morin (INSERM: Inserm)H-Index: 2
Last. Mina Tadrous (University of Toronto)H-Index: 19
view all 7 authors...
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#1Neriman İpek Kırmızı (Istanbul Medipol University)H-Index: 1
#2Volkan Aydin (Istanbul Medipol University)H-Index: 4
Last. Ahmet Akici (MU: Marmara University)H-Index: 15
view all 3 authors...
BACKGROUND Controversies exist about excessive use of gastric acid-suppressing agents or lack of adequate indications, especially when co-prescribed with analgesics for gastroprotection. We aimed to analyze the nationwide trend of gastric acid-suppressing agents and analgesics. METHODS We obtained nationwide consumption data of analgesics (nonsteroidal anti-inflammatory drugs [NSAIDs], opioids, others) and gastric acid-suppressing agents (proton pump inhibitors [PPI] and histamine-2 receptor ant...
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#1Jim Young (MUHC: McGill University Health Centre)H-Index: 1
#2Vincent Lo Re (University of Pennsylvania)H-Index: 33
Last. Marina B. Klein (MUHC: McGill University Health Centre)H-Index: 64
view all 12 authors...
PURPOSE Despite effective antiretroviral therapy, rates of end-stage liver disease (ESLD) remain high. It is not clear whether contemporary antiretrovirals contribute to the risk of ESLD. METHODS We included patients from cohorts with validated ESLD data in the North American AIDS Cohort Collaboration on Research and Design. Patients had to initiate antiretroviral therapy after 1 January 2004 with a nucleos(t)ide backbone of either abacavir/lamivudine or tenofovir/emtricitabine and a contemporar...
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#1Lars Christian Lund (SDU: University of Southern Denmark)H-Index: 10
#2Mikkel Højlund (SDU: University of Southern Denmark)H-Index: 3
Last. Kasper Bruun Kristensen (SDU: University of Southern Denmark)H-Index: 8
view all 5 authors...
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#1Reem Masarwa (McGill University)H-Index: 10
#2Claire E. Lefebvre (Centre Hospitalier Universitaire Sainte-Justine)H-Index: 1
Last. Kristian B. Filion (McGill University)H-Index: 52
view all 4 authors...
PURPOSE To describe the prescribing trends of 17 therapeutic drug categories and the specific drug classes of systemic antibiotics, analgesics, and antidepressants in children and adolescents in the United Kingdom between 1998 and 2018. METHODS A population-based retrospective cohort study including children and adolescents aged 018 years. Overall and annual prescription rates per 10 000 person-years and corresponding 95% confidence intervals (CIs) were calculated. Rate ratios and 95% CIs were c...
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