Metallomics
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#1Haoxuan Ding (ZJU: Zhejiang University)H-Index: 3
#2Qian Zhang (ZJU: Zhejiang University)
Last. Jie Feng (ZJU: Zhejiang University)H-Index: 14
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Iron overload is an important contributor to disease. The liver, the major site of iron storage in the body, is a key organ impacted by iron overload. While several studies have reported perturbations in liver lipids in iron overload, it is not clear, on a global scale, how individual liver lipid ions are altered. Here, we used lipidomics to study the changes in hepatic lipid ions in iron-overloaded mice. Iron overload was induced by daily intraperitoneal injections of 100mg/kg body weight iron ...
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#1Jenna Greve (OSU: Ohio State University)
#2Andrew M. Pinkham (OSU: Ohio State University)H-Index: 2
Last. James A. Cowan (OSU: Ohio State University)H-Index: 38
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Human aspartyl/asparaginyl beta-hydroxylase (HAAH) is a member of the superfamily of nonheme Fe2+/α-ketoglutarate (αKG) dependent oxygenase enzymes with a noncanonical active site. HAAH hydroxylates epidermal growth factor (EGF) like domains to form the β-hydroxylated product from substrate asparagine or aspartic acid and has been suggested to have a negative impact in a variety of cancers. In addition to iron, HAAH also binds divalent calcium, although the role of the latter is not understood. ...
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#1Catarina Pimpão (University of Lisbon)H-Index: 2
#2Darren Wragg (TUM: Technische Universität München)H-Index: 5
Last. Angela Casini (TUM: Technische Universität München)H-Index: 79
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The inhibition of glycerol permeation via human aquaporin-10 (hAQP10) by organometallic gold complexes has been studied by stopped-flow fluorescence spectroscopy, and its mechanism has been described using molecular modelling and atomistic simulations. The most effective hAQP10 inhibitors are cyclometalated Au(III) C^N compounds known to efficiently react with cysteine residues leading to the formation of irreversible C-S bonds. Functional assays also demonstrate the irreversibility of the bindi...
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#1Kaitlin Casanova-Hampton (A&M: Texas A&M University)
#2Alexis Carey (A&M: Texas A&M University)
Last. Sargurunathan Subashchandrabose (A&M: Texas A&M University)H-Index: 12
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Copper (Cu) is a key transition metal that is involved in many important biological processes in a cell. Cu is also utilized by the immune system to hamper pathogen growth during infection. However, genome-level knowledge on the mechanisms involved in adaptation to Cu stress is limited. Here, we report the results of a genome-wide reverse genetic screen for Cu-responsive phenotypes in Escherichia coli. Our screen has identified novel genes involved in adaptation to Cu stress in E. coli. We detec...
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#1Dandan Yang (HAU: Huazhong Agricultural University)H-Index: 1
#2Chengxiao Hu (HAU: Huazhong Agricultural University)H-Index: 22
Last. Xiaohu Zhao (HAU: Huazhong Agricultural University)H-Index: 17
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Selenium (Se) is a component of many enzymes and indispensable for human health due to its characteristics of reducing oxidative stress and enhancing immunity. Human beings take Se mainly from Se-containing crops. Taking measures to biofortify crops with Se may lead to improved public health. Se accumulation in plants mainly depends on the content and bioavailability of Se in soil. Beneficial microbes may change the chemical form and bioavailability of Se. This review highlights the potential ro...
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#1Kira G. Slepchenko (OU: Ohio University)H-Index: 7
#2Si Chen (Argonne National Laboratory)
Last. Craig S. Nunemaker (OU: Ohio University)H-Index: 31
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Pancreatic beta-cells synthesize and secrete insulin maintaining an organism's energy homeostasis. In humans, beta-cell dysfunction and death contribute to the pathogenesis of type 2 diabetes (T2D). Although the causes of beta-cell dysfunction are complex, obesity-induced low- grade systemic inflammation plays a role. For example, obese individuals exhibiting increased levels of proinflammatory cytokines IL-6 and IL-1beta have a higher risk of beta-cell dysfunction and T2D. Interestingly, obesit...
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#1Afsana Mahim (UWM: University of Wisconsin–Milwaukee)H-Index: 1
Last. David H. Petering (UWM: University of Wisconsin–Milwaukee)H-Index: 54
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The cellular trafficking pathways that conduct zinc to its sites of binding in functional proteins remain largely unspecified. In this study, the hypothesis was investigated that nonspecific proteomic binding sites serve as intermediates in zinc trafficking. Proteome from pig kidney LLC-PK1 cells contains a large concentration of such sites, displaying an average conditional stability constant of 1010-11, that are dependent on sulfhydryl ligands to achieve high-affinity binding of zinc. As a res...
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#1Yoshiaki Furukawa (Keio: Keio University)H-Index: 24
#2Atsuko Shintani (Keio: Keio University)
Last. Teppei Kokubo (Keio: Keio University)
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Bacterial Cu/Zn-superoxide dismutase (SodC) is an enzyme catalyzing the disproportionation of superoxide radicals, to which the binding of copper and zinc ions and the formation of an intramolecular disulfide bond are essential. We previously showed that Escherichia coli SodC (SodC) was prone to spontaneous degradation in vivo in an immature form prior to the introduction of the disulfide bond. The post-translational maintenance involving the metal binding and the disulfide formation would thus ...
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#1Irthasa Aazem (CUSAT: Cochin University of Science and Technology)H-Index: 2
Last. G. S. Sailaja (CUSAT: Cochin University of Science and Technology)H-Index: 9
view all 7 authors...
Active surfaces with bactericidal properties are of paramount importance in health care sector as a judicious approach to confront prevalent challenges presented by disastrous pathogenic infections and antibiotic-resistant microbes. Herein, we present Bayerite underpinned Ag2O/Ag (ALD), a nanohybrid with excellent antibacterial and antibiofilm functionalities against tested standard strains and clinical isolates. The multicomponent system coexists and complement each other with respect to phase ...
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#1Bing Wang (NEAU: Northeast Agricultural University)H-Index: 2
#2Yuan Cui (NEAU: Northeast Agricultural University)H-Index: 5
Last. Shiwen Xu (NEAU: Northeast Agricultural University)H-Index: 52
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Selenium (Se) was involved in many physiological processes in humans and animals. microRNAs (miRNAs) also played important roles in lung diseases. However, the regulatory mechanism of miRNA in chicken lungs and the mechanism of lipopolysaccharide (LPS)-induced pneumonia remained unclear. To further study these mechanisms, we established a supplement of selenomethionine (SeMet) and/or LPS-treated chicken model and a cell model of LPS and/or high and low expression of miR-15a in chicken hepatocell...
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Top fields of study
Inorganic chemistry
Chemistry
Zinc
Metal
Copper
Biochemistry
Stereochemistry
Biology
Cell biology