Tetrahedron Letters
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#1Mingliang Wang (Zhejiang University of Technology)H-Index: 2
#2Dongping Cheng (Zhejiang University of Technology)H-Index: 7
Last. Xiaoliang Xu (Zhejiang University of Technology)H-Index: 16
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Abstract null null A DDQ-mediated tandem annulation of 2-aminochromones with 1,3-diarylpropenes is disclosed, which provides the azaxanthones in moderate to good yields. The oxidative coupling, intramolecular cyclization and dehydro-aromatization might be involved in this high atom-efficiency reaction.
#1Takahiro Noro (Tohoku University)H-Index: 3
#2Juri Sakata (Tohoku University)H-Index: 3
Last. Hidetoshi Tokuyama (Tohoku University)H-Index: 49
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Abstract null null This paper describes synthetic studies on a discorhabdin alkaloid with C2-N18 bond comprising the A–F hexa-cyclic framework. This specific bond was formed at the early stage of the synthesis by Mitsunobu reaction, and then a tryptamine derivative with E ring was converted to a tricyclic o-quinone intermediate via an aerobic oxidative cascade cyclization. Later in the synthesis, the D/E/F ring system incorporating E/D aza-spirocycle with C6 quaternary carbon center and the F/E ...
#1Somayeh Behrouz (Heidelberg University)
#2Nikos Kühl (Heidelberg University)H-Index: 2
Last. Christian D. Klein (Heidelberg University)H-Index: 29
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Abstract null null The amidine function is extensively utilized as synthetic intermediate for structurally diverse heterocycles and as a core element in drugs and drug candidates. This study describes a facile and convenient approach for the highly efficient synthesis of amidinophenylalanine derivatives via the reduction of amidoximophenylalanines in the presence of Ac2O/AcOH/Zn at room temperature. The described process is attractive for process and medicinal chemistry due to its facility, safe...
Abstract null null P(O)-H compounds like H-phosphonates, H-phosphinates and secondary phosphine oxides are widely used in radical reactions. Their great successes are rooted in the facile homolytic cleavage of P-H bond. Herein, recent advances of these compounds were summarized as five pathways according to their mechanisms: (1) radical addition and cyclization; (2) cyclization and ring-opening; (3) radical addition and coupling; (4) radical addition and elimination; (5) coupling with nucleophil...
#1Shiyu Sun (FIT: Florida Institute of Technology)H-Index: 1
#2Carlyn Reep (FIT: Florida Institute of Technology)H-Index: 2
Last. Norito Takenaka (FIT: Florida Institute of Technology)H-Index: 15
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Abstract null null A new strategy to effectively lock the conformation of substituents at the 3,3’-positions of axial-chiral biisoquinoline N,N’-dioxides was developed based on the strong dipole–dipole interaction between 1,2,3-triazole and pyridine N-oxide rings. The crystal structure and the DFT calculations of 3,3’-bis(1-benzyl-1H-1,2,3-triazole-4-yl)-1,1’-biisoquinoline N,N’-dioxide (3a) provided strong support for this strategy. Furthermore, we successfully demonstrated that readily availab...
#1Krishanu Bera (IITs: Indian Institutes of Technology)
#2Arup Mukherjee (IITs: Indian Institutes of Technology)H-Index: 27
Abstract null null The synthesis of N-heterocycles is considered to be an emerging field in synthetic chemistry owing to their application in the pharmaceutical as well as bulk and fine chemical industries. The disadvantages associated with the classical methods for the synthesis of these N-heterocycles involves multiple synthetic steps, scarcity of the starting materials and stoichiometric waste generation. Acceptorless dehydrogenative coupling and borrowing hydrogen methodology provide an alte...
#1Jingyang Wang (SJTU: Shanghai Jiao Tong University)
#2Yu Wang (SJTU: Shanghai Jiao Tong University)H-Index: 60
Last. Xiaomin Xie (SJTU: Shanghai Jiao Tong University)H-Index: 16
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Abstract null null An efficient and mild catalytic deallylation method of aryl allyl ethers is developed, with commercially available Ni(COD)2 as catalyst precursor, simple substituted bipyridine as ligand and air-stable hydrosilanes. The process is compatible with a variety of functional groups and the desired phenol products can be obtained with excellent yields and selectivity. Besides, by detection or isolation of key intermediates, mechanism studies confirm that the deallylation undergoes η...
#1Shruti S. Malunavar (Karnatak Science College)H-Index: 3
#2Suraj M. Sutar (Karnatak Science College)H-Index: 3
Last. Kenneth K. Laali (UNF: University of North Florida)H-Index: 27
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Abstract null null The potential of [PAIM][NTf2]/BMIM-ILs as a base/solvent in the Corey-Chaykovsky reaction is demonstrated by the facile synthesis of libraries of functionalized cyclopropanes from enones and oxiranes from aldehydes and ketones, at room temperature in respectable isolated yields. To demonstrate their application, the synthesized epoxides were employed as substrates for the synthesis of a library of 2,3-disubstituted quinolines, using [BMIM(SO3H)][OTf]/[BMIM][PF6] as a catalyst/...
#1Ha-Thanh Nguyen (VAST: Vietnam Academy of Science and Technology)
#2Tuyet Anh Dang Thi (VAST: Vietnam Academy of Science and Technology)H-Index: 10
Last. Tuyen Van Nguyen (VAST: Vietnam Academy of Science and Technology)H-Index: 13
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Abstract null null A facile and efficient synthesis of novel naphthoquinone-based chalcone hybrids (7 and 24) via the microwave-assisted one-pot three-component reactions of 2-substituted-1,4-naphthoquinones, N,N-dimethylformamide dimethyl acetal (DMF-DMA), and acetophenone derivatives has been reported. Whereas the synthesis of hybrids 7 proceeded via a condensation, 1,4-addition, rotation, elimination, and [1,3]-H shift sequence of steps, the synthesis of hybrids 24 were formed through a three...
#1Shengguo Duan (ZSTU: Zhejiang Sci-Tech University)H-Index: 2
#2Qiaoyi Xiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 1
Last. Ze-Feng Xu (ZSTU: Zhejiang Sci-Tech University)
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Abstract null null The first formal intramolecular 1,3-insertion into O Si bond of rhodium(II) azavinyl carbene have been developed, and valuable phthalan derivatives could be synthesized efficiently. In addition, various functional groups could be introduced to the product conveniently in the assistant of TBAF.
Top fields of study
Medicinal chemistry
Organic chemistry