Tetrahedron Letters
IF
2.42
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98.8k
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Newest
#1Kimberly Perry (USC: University of South Carolina)
#2Binglin Sui (USC: University of South Carolina)
Last. Yangmei Li (USC: University of South Carolina)
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Abstract null null The revival of peptide-based drugs has led to the increasing demand for the development of large-scale synthesis of these complex molecules. To meet this demand, the use of mercapto-functionalized polyhedral oligomeric silsesquioxane (POSS-SH) as a soluble support for the synthesis of a model pentapeptide POSS-thioester is reported. The synthetic process provided a total yield of 62% for the pentapeptide POSS-thioester and the 1H NMR spectra validated the high purity of the pr...
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#1Pampa Maity (CU: University of Calcutta)H-Index: 3
#2Piyali Sarkar (CU: University of Calcutta)H-Index: 6
Last. Chhanda Mukhopadhyay (CU: University of Calcutta)H-Index: 25
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Abstract null null A new, efficient and operationally simple copper mediated C−I, C S and C−Se bond formation protocol has been developed. This process proceeds smoothly under mild aerobic condition to give C H iodinated, sulfenylated and selenenylated pyrrolo[3,4–c]pyridines derivative. The versatility of this process has been successfully established by simply varying different electrophile. This copper iodide-mediated C H functionalization approach provides a direct access of structurally div...
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#1Yuichiro Kawamoto (TUPLS: Tokyo University of Pharmacy and Life Sciences)H-Index: 3
#2Naoki Noguchi (TUPLS: Tokyo University of Pharmacy and Life Sciences)
Last. Hisanaka Ito (TUPLS: Tokyo University of Pharmacy and Life Sciences)H-Index: 19
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Abstract null null Chiral quaternary carbon-containing bicyclic compounds possessing carbonyl functionalities were efficiently synthesized through asymmetric intramolecular aldol reactions with organocatalysts. Bicyclo [3.3.0] and [3.4.0] systems were constructed with a diamine catalyst, while bicyclo [4.3.0] and [4.4.0] skeletons were prepared by an acylsulfonamide type catalyst.
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#1Wei Huiqin (FJMU: Fujian Medical University)
#2Mei Wu (FJMU: Fujian Medical University)
Abstract null null A transition-metal-free hydroxylation of iodoarenes to afford substituted phenols is described. The reaction is promoted by KI under white LED light irradiation and uses atmospheric oxygen as oxidant. By the use of triethylamine as base and solvent, the corresponding phenols are obtained in moderate to good yields. Mechanistic studies suggest that KI and catalysis synergistically promote the cleavage of C-I bond to form free aryl radicals.
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#1Qiang Wang (SEAC: State Ethnic Affairs Commission)
#2Jiahao Lou (SEAC: State Ethnic Affairs Commission)
Last. Jun-Lin Yin (SEAC: State Ethnic Affairs Commission)
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Abstract null null A novel sesquiterpenoid, named Cyperensol A (1), was isolated from the rhizomes of Cyperus rotundus L. Its structure was elucidated extensively by the spectroscopic analysis. Possible biosynthetic pathway of 1 was proposed. Compound 1 showed inhibitory activity on IL-6 induced activation of JAK/STAT3 signaling pathway with IC50 value of 189.37 ± 7.20 μM.
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#1Xiao-Hui Chen (CQU: Chongqing University)H-Index: 2
#2Xue Xiao (CQU: Chongqing University)H-Index: 1
Last. Hai-Lei Cui (CQU: Chongqing University)H-Index: 11
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Abstract null null A series of pyrroloisoquinolines have been modified via dicarbonylation with DMSO and arylacyl bromides. Highly functionalized 1,2-diketones bearing privileged frameworks can be prepared in acceptable to good yields (12-73%).
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#1Reihane Peirow (UT: University of Tehran)
#2Mehdi Adib (UT: University of Tehran)H-Index: 32
Last. Mohammad Mahdavi (TUMS: Tehran University of Medical Sciences)H-Index: 33
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Abstract null null A novel, one-pot, mild and operationally simple synthetic approach for the synthesis of pyrazino[1,2-a]indole derivatives is reported. The reaction proceeds via a 4-component Ugi condensation followed by N-annulation of the intermediate to afford the titled product under metal and acid-free conditions in methanol. The procedure consists of one-step tandem condensation and cyclization of Indole-2-carboxylic acid with isocyanides, phenacylamine hydrochloride and a variety of aro...
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#1Xuesong Wang (THU: Tsinghua University)H-Index: 7
#2Dongping Luo (THU: Tsinghua University)H-Index: 3
Last. Yuefei Hu (THU: Tsinghua University)H-Index: 22
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Abstract null null A new synthesis of diaryl sulfones is achieved from N,N'-disulfonylhydrazides and diaryliodonium salts. Its key advantage is that N,N'-disulfonylhydrazides carry out an efficient base-promoted evolution of nitrogen to generate in situ ammonium sulfinates with good solubility and high reactivity. N,N'-Disulfonylhydrazides prove to be an excellent synthetic equivalent of sulfinic acids and their salts with none of their drawbacks.
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#1Maity Ak (IISER: Indian Institute of Science Education and Research, Bhopal)H-Index: 7
#2Mintu Munda (IISER: Indian Institute of Science Education and Research, Bhopal)H-Index: 1
Last. Alakesh Bisai (IISER: Indian Institute of Science Education and Research, Bhopal)H-Index: 25
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Abstract null null A general strategy for asymmetric approach to the hexahydropyrrolo[2,3-b]indole alkaloids sharing a vicinal quaternary-tertiary centers has been disclosed via Pd(0)-catalyzed N-deacylative allylations (N-DaA) (dr > 20:1). Utilizing this strategy, asymmetric total syntheses of pseudophrynamines 270 (3c) and 272A (3b) have been achieved from a 3-substituted N-acyl indole 8 (pro-nucleophile) with allyl alcohol (pro-electrophile).
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#1Zhi-Wei Wang (Qilu University of Technology)H-Index: 4
#2Jin-Ping Zhang (Qilu University of Technology)
Last. Xiao-Jing Wang (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 14
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Abstract null null Rupestrisine A (1), an unprecedented heteroyohimbine-kopsinine type dimeric indole alkaloid, and rupestrisine B (2), the first example of yohimbine-kopsinine type bisindole alkaloid, were isolated from Alstonia rupestris. Their structures were elucidated based on 1D and 2D-NMR, MS, ECD, FTIR and UV spectroscopic data. Compound 1 showed moderate activity of inhibiting NO production of RAW264.7 cells induced by lipopolysaccharide with an IC50 value of 17.5 ± 1.6 μM.
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