Journal of Molecular Neuroscience
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3589
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Mesenchymal stem cells (MSCs)-derived exosomes play significant roles in alleviating spinal cord injury (SCI). Previous study showed that long non-coding RNA tectonic family member 2 (TCTN2) was able to relieve SCI. Herein, whether TCTN2 exerted its roles in functional recovery after SCI via exosomes derived from MSCs was explored. The SCI model was established in rats, and the neurological function was evaluated using the Basso, Beattie, and Bresnahan (BBB) scoring. Lipopolysaccharide (LPS)-ind...
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#1Soudeh Ghafouri-Fard (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 26
Last. Arezou Sayad (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 16
view all 8 authors...
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immunological disorder. Although the precise pathoetiology of CIDP has not been clarified yet, it is believed that both B and T cells of immune system contribute in this disorder. Based on the importance of human leukocyte antigen (HLA) cluster in the regulation of immune responses, this family of proteins is putative determinants of risk of CIDP. We conducted the current investigation to appraise association between HLA all...
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#1Fatemehsadat Seyedaghamiri (Tabriz University of Medical Sciences)
#2Javad Mahmoudi (Tabriz University of Medical Sciences)H-Index: 19
Last. Mehdi Farhoudi (Tabriz University of Medical Sciences)H-Index: 17
view all 5 authors...
Post-stroke disabilities like cognitive impairment impose are complex conditions with great economic burdens on health care systems. For these comorbidities, no effective therapies have been identified yet. Nicotinic acetylcholine receptors (nAChRs) are multifunctional receptors participating in various behavioral and neurobiological functions. During brain ischemia, the increased glutamate accumulation leads to neuronal excitotoxicity as well as mitochondrial dysfunction. These abnormalities th...
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#1Maria Papasavva (UoA: National and Kapodistrian University of Athens)H-Index: 5
#2Michail VikelisH-Index: 11
Last. Nikolaos Drakoulis (UoA: National and Kapodistrian University of Athens)H-Index: 22
view all 10 authors...
Cluster headache (CH) is a primary headache disorder with a complex genetic background. Several studies indicate a potential link between iron homeostasis and the pathophysiology of primary headaches. The HFE gene encodes for a protein involved in iron metabolism, while genetic variants in HFE have been associated with hereditary hemochromatosis (HH), an iron overload disorder. The objective of the current study was to examine the association of the more common HFE H63D variant, with the suscept...
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#1Huai-Gen Zhang (NCU: Nanchang University)
#2Li Liu (NCU: Nanchang University)
Last. Da-Ying Zhang (NCU: Nanchang University)
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Neuropathic pain (NP) involves metabolic processes that are regulated by metabolic genes and their non-coding regulator genes such as microRNAs (miRNAs). Here, we aimed at exploring the key miRNA signatures regulating metabolic genes involved in NP pathogenesis. We downloaded NP-related data from public databases and identified differentially expressed microRNAs (miRNAs) and mRNAs through differential gene expression analysis. The miRNA target prediction was performed, and integration with the d...
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#1Shuaiqun Wang (Shanghai Maritime University)H-Index: 8
#2Yafei Qian (Shanghai Maritime University)
Last. Wei Kong (Shanghai Maritime University)
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Using correlation analysis to study the potential connection between brain genetics and imaging has become an effective method to understand neurodegenerative diseases. Sparse canonical correlation analysis (SCCA) makes it possible to study high-dimensional genetic information. The traditional SCCA methods can only process single-modal genetic and image data, which to some extent weaken the close connection of the brain's biological network. In some recently proposed multimodal SCCA methods, due...
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#1Liang Yang (Hebei Medical University)H-Index: 3
#2Nan Li (Hebei Medical University)H-Index: 1
Last. Zongmao Zhao (Hebei Medical University)H-Index: 1
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As one of the main types of secondary craniocerebral injury, the onset, progression, and prognosis of chronic subdural hematoma (CSDH) are closely related to the local inflammation of intracranial hematoma. Atorvastatin is reported to be effective in the conservative treatment of CSDH. This study aimed to clarify whether atorvastatin regulated the inflammatory responses in CSDH by interfering with the function of macrophages. The rat CSDH model was prepared by repeated intracranial blood injecti...
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#1Kang-Zhen ChenH-Index: 2
#2Lu Ding (SYSU: Sun Yat-sen University)H-Index: 3
Last. Wu Hongfu
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Brachial plexus avulsion (BPA) is a devastating traumatic peripheral nerve injury complicated with paralysis of the upper extremity. We previously reported that leucine-rich repeat and immunoglobulin-like domain-containing NOGO receptor-interacting protein 1 (LINGO-1) has a potent role in inhibiting neuron survival and axonal regeneration after the central nervous system (CNS) damage and miR-615 is a potential microRNA (miRNA) negatively regulated LINGO-1. However, the effect of miR-615 in BPA r...
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#1Malak Al-Jumaiah (KSU: King Saud University)
#2Mona Alonazi (KSU: King Saud University)H-Index: 4
Last. Afaf El-Ansary (KSU: King Saud University)H-Index: 26
view all 7 authors...
The present study investigated that maternal type 1 diabetes may contribute to autism pathogenesis in offspring, and that insulin therapy during pregnancy may prevent the onset of autism. As evidenced, selected brain biomarkers representing the accepted etiological mechanism of autism in newborn rats from diabetic mothers and diabetic mothers receiving insulin therapy compared to the propionic acid (PPA) rodent model of autism were screened. Female Wistar rats with a controlled fertility cycle w...
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