Acta Pharmacologica Sinica
Papers 7,165
1 page of 717 pages (7,165 results)
#1Fangfang Cai (NU: Nanjing University)H-Index: 6
#2Huangru Xu (NU: Nanjing University)H-Index: 4
Last. Zi-Chun Hua (NU: Nanjing University)H-Index: 45
view all 11 authors...
Hydrogen sulfide (H2S) is widely recognized as the third endogenous gas signaling molecule and may play a key role in cancer biological processes. ADT-OH (5-(4-hydroxyphenyl)-3H-1,2-dithiocyclopentene-3-thione) is one of the most widely used organic donors for the slow release of H2S and considered to be a potential anticancer compound. In this study, we investigated the antimetastatic effects of ADT-OH in highly metastatic melanoma cells. A tail-vein-metastasis model was established by injectin...
#1Hong-Jin Wang (SWU: Southwest University)H-Index: 3
#2Hai-Feng Ran (SWU: Southwest University)
Last. Xiaoyu XuH-Index: 1
view all 13 authors...
Neurovascular unit (NVU) is organized multi-cellular and multi-component networks that are essential for brain health and brain homeostasis maintaining. Neurovascular unit dysfunction is the central pathogenesis process of ischemic stroke. Thus integrated protection of NVU holds great therapeutic potential for ischemic stroke. Catalpol, classified into the iridoid monosaccharide glycoside, is the main active ingredient of the radix from traditional Chinese medicine, Rehmannia glutinosa Libosch, ...
#1Cheng Chen (UM: University of Macau)
#2Yong-Mei Ren (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Ligen Lin (UM: University of Macau)H-Index: 28
view all 8 authors...
Interleukin-1β (IL-1β), a key pro-inflammatory cytokine, is majorly produced by macrophages through NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome, which has been identified as the culprit to deteriorate the inflammatory crosstalk between macrophages and adipocytes. Ainsliadimer C (AC) is a disesquiterpenoid isolated from Ainsliaea macrocephala. In the current study, we investigated the effects of AC on adipose tissue inflammation in co-culture of macrophages and adipocyt...
#1Shuang Hu (Anhui Medical University)H-Index: 4
#2Yan Yao (Anhui Medical University)
Last. Tao Xu (Anhui Medical University)H-Index: 16
view all 13 authors...
Acetaminophen (APAP) is one of the major causes of drug-induced acute liver injury, and ethanol may aggravate APAP-induced liver injury. The problem of ethanol- and APAP-induced liver injury becomes increasingly prominent, but the mechanism of ethanol- and APAP-induced liver injury remains ambiguous. p38γ is one of the four isoforms of P38 mitogen activated protein kinases, that contributes to inflammation in different diseases. In this study we investigated the role of p38γ in ethanol- and APAP...
#1Hui-xi Zou (CUHK: The Chinese University of Hong Kong)
#2Yufeng Zhang (CUHK: The Chinese University of Hong Kong)H-Index: 9
Last. Xiaoyu Yan (CUHK: The Chinese University of Hong Kong)H-Index: 9
view all 9 authors...
Furmonertinib (AST2818) is a novel third-generation irreversible EGFR TKI and recently has been approved in China for the treatment of non-small cell lung cancer (NSCLC) with EGFR-sensitizing and T790M resistance mutations. In the current study, we developed a semi-mechanistic population pharmacokinetic model to characterize the nonstationary pharmacokinetics (PK) of the furmonertinib and its active metabolite AST5902 simultaneously. The PK data of furmonertinib and AST5902 were obtained from 38...
#1Xin Chen (Third Military Medical University)H-Index: 6
#2Jie Liu (Third Military Medical University)
Last. Xiaohui Li (Third Military Medical University)H-Index: 30
view all 12 authors...
#1Yang Li (CPU: China Pharmaceutical University)H-Index: 1
#2Bo-Xue Ren (CPU: China Pharmaceutical University)H-Index: 2
Last. Zhao-Qiu Wu (CPU: China Pharmaceutical University)H-Index: 6
view all 6 authors...
Omeprazole is a proton pump inhibitor that has recently been reported to exhibit anticancer activity against several types of cancer. However, the anticancer mechanisms of omeprazole remain elusive. Snail is an oncogenic zinc finger transcription factor; aberrant activation of Snail is associated with the occurrence and progression of cancer. In this study, we investigated whether Snail acted as a direct anticancer target of omeprazole. We showed that omeprazole displayed a high binding-affinity...
#1Jian Dong (NU: Nanjing University)H-Index: 2
#2Kaijia Zhang (NU: Nanjing University)H-Index: 10
Last. Qing Jiang (NU: Nanjing University)H-Index: 35
view all 11 authors...
Osteoarthritis (OA) is the most prevalent chronic degenerative joint disease with few treatment options. The pathogenesis of OA is characterized by sustained inflammation, oxidative stress and chondrocyte apoptosis that eventually lead to cartilage degradation and joint dysfunction. In the present study, we identified a synthetic triterpenoid CDDO-Im(1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole) as an activator of Nrf2 (nuclear factor erythroid 2-related factor 2) that displayed st...
#1Wu Luo (WMU: Wenzhou Medical College)H-Index: 10
#2Libin Yang (WMU: Wenzhou Medical College)
Last. Yi Wang (WMU: Wenzhou Medical College)H-Index: 61
view all 13 authors...
Acute lung injury (ALI) is a sudden onset systemic inflammatory response. ALI causes severe morbidity and death and currently no effective pharmacological therapies exist. Natural products represent an excellent resource for discovering new drugs. Screening anti-inflammatory compounds from the natural product bank may offer viable candidates for molecular-based therapies for ALI. In this study, 165 natural compounds were screened for anti-inflammatory activity in lipopolysaccharide (LPS)-challen...
#1Wei Feng (SYSU: Sun Yat-sen University)H-Index: 19
#2Xi Chen (SYSU: Sun Yat-sen University)H-Index: 76
Last. Li Zhang (SYSU: Sun Yat-sen University)H-Index: 76
view all 17 authors...
Gefitinib has been available in the market for 20 years, but its pharmacokinetic mechanism of response is little known. In this study, we examined the pharmacokinetic and metabolomic profiles in non-small cell lung cancer (NSCLC) patients with sensitive EGFR mutations. A total of 216 advanced NSCLC patients were enrolled, and administered gefitinib at the standard dosage of 250 mg/day, which was established in heterogeneous subjects with non-sensitive mutations. We identified and quantified thre...
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