Diagnostic Pathology
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#1Giovanna Giordano (University of Parma)H-Index: 17
#2Chiara Petrolini (Boston Children's Hospital)
Last. Serafina Perrone (Boston Children's Hospital)H-Index: 1
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Introduction null COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, is a severe systemic thrombotic syndrome that emerged in 2019, with an ensuing pandemic. To evaluate the impact of this disease on placental tissue and perinatal outcome, histological, immunohistochemical and ultrastructural analyses of placental tissue were performed for five cases of pregnant women with COVID-19. null Case reports null All five pregnant women in this series developed COVID-19 in late pregnancy....
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BACKGROUND Soft tissue perineurioma of the kidney is rare, with only a few reported cases. We report two additional cases with histologic, immunohistochemical and genetic analyses. CASE PRESENTATION Both tumors were from adults (1 female aged 49 years and 1 male aged 42 years) and grossly had maximum diameters of 6.5 and 10 cm, respectively. The tumors were overall well circumscribed but unencapsulated, with focally entrapped benign native renal tubules in one case; both tumors seemed to arise i...
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#1Sofia S Liou (UCLA: University of California, Los Angeles)H-Index: 1
#2Neshat Nilforoushan (UCLA: University of California, Los Angeles)
Last. Neda A. Moatamed (UCLA: University of California, Los Angeles)H-Index: 13
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BACKGROUND The aim of this study was to determine how Stathmin-1 and Heat Shock Protein 27 (HSP27) can be used as adjunctive biomarkers to differentiate high-grade dysplasia from benign/reactive lesions in cervical tissues. In addition, we aimed to see if any of these markers can differentiate endometrial from endocervical adenocarcinomas. METHODS Fifty cases including benign cervical tissue, low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), ade...
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#1Irene Y. Chen (URMC: University of Rochester Medical Center)
#2Christa L. Whitney-Miller (URMC: University of Rochester Medical Center)H-Index: 10
Last. Xiaoyan Liao (URMC: University of Rochester Medical Center)H-Index: 8
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BACKGROUND Congenital hepatic fibrosis (CHF) is a rare inherited form of ductal plate malformation associated with polycystic kidney disease. The diagnosis requires histopathologic confirmation, but can be challenging to distinguish from other undefined fibrocystic liver diseases. We aimed to describe the clinicopathologic features of congenital hepatic fibrosis (CHF), with comparisons to other entities that may clinically and/or histologically mimic CHF. METHODS Nineteen cases that carried a cl...
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#1Haibin Zhong (STU: Shantou University)
#2Yang Zheng (STU: Shantou University)
Last. Feiran Zhang (STU: Shantou University)
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Background null Monomorphic epitheliotropic intestinal T-cell lymphomas (MEITL) is a rare and aggressive subtype of lymphoma. The most common site of origin is small intestine. Patients are often presented with diagnosis of intestinal perforation with abdominal pain as the main consulting symptoms. Because of the deficiency of specific diagnostic measures and effective management, diagnosis is often confirmed in advanced stage with poor prognosis. null Case presentation null Here, we introduce a...
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#1Shintaro Sugita (Sapporo Medical University)H-Index: 12
#2Tomoyuki Aoyama (Sapporo Medical University)H-Index: 9
Last. Tadashi Hasegawa (Sapporo Medical University)H-Index: 62
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Background null A definitive diagnosis of malignant peripheral nerve sheath tumor (MPNST) is challenging, especially in cases without neurofibromatosis 1 (NF1), because MPNST lacks specific markers on immunohistochemistry (IHC). null Methods null We performed IHC for histone 3 trimethylated on lysine 27 (H3K27me3) and evaluated the percentage of cells with H3K27me3 loss using measured values at 10% intervals, categorized as complete loss (100% of tumor cells lost staining), partial loss (10% to ...
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#1Yan Wu (PKU: Peking University)H-Index: 1
#2Yumei Lai (PKU: Peking University)H-Index: 8
Last. Zhongwu Li (PKU: Peking University)H-Index: 21
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Background null Melanoma is a highly malignant tumor with diverse histopathological morphology and frequent aberrant expression of immunohistochemical markers. An occasionally reported phenomenon is the abnormal expression of neuroendocrine markers. Awareness of this situation is essential because such tumors need to be differentiated from neuroendocrine tumors because of their significant therapeutic and prognostic implications. null Methods null We retrospectively analyzed the expression of ch...
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BACKGROUND Histopathological classification of Wilms tumors determines treatment regimen. Machine learning has been shown to contribute to histopathological classification in various malignancies but requires large numbers of manually annotated images and thus specific pathological knowledge. This study aimed to assess whether trained, inexperienced observers could contribute to reliable annotation of Wilms tumor components for classification performed by machine learning. METHODS Four inexperie...
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#1Lisa Browning (University of Oxford)H-Index: 9
#2Richard Colling (John Radcliffe Hospital)H-Index: 10
Last. Clare Verrill (John Radcliffe Hospital)H-Index: 22
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BACKGROUND There are recognised potential pitfalls in digital diagnosis in urological pathology, including the grading of dysplasia. The World Health Organisation/International Society of Urological Pathology (WHO/ISUP) grading system for renal cell carcinoma (RCC) is prognostically important in clear cell RCC (CCRCC) and papillary RCC (PRCC), and is included in risk stratification scores for CCRCC, thus impacting on patient management. To date there are no systematic studies examining the conco...
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#1Charlotte Holmes (Freeman Hospital)
#2Peh Sun Loo (Freeman Hospital)
Last. Sion Barnard (Freeman Hospital)H-Index: 7
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BACKGROUND First described in 1955 Primary mediastinal seminomas are rare. Only 1-4% of mediastinal tumours are germ cell tumors; majority of which are teratomas. They typically present in men aged between 20 and 40 years. Very few cases are reported in the literature. Florid follicular lymphoid hyperplasia can obscure the malignant cells and is a rarer finding still. We present a rare case of a 48 year old man with a primary mediastinal seminoma with florid follicular lymphoid hyperplasia; foun...
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Immunohistochemistry
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