Oncology Reports
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#1Jeong-Mi Kim (CBNU: Chonbuk National University)H-Index: 13
#2Jinny Park (Gachon University)H-Index: 20
Last. Young-Rae Lee (Wonkwang University)H-Index: 26
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Matriptases, members of the type II transmembrane serine protease family, are cell surface proteolytic enzymes that mediate tumor invasion and metastasis. Matriptase is highly expressed in breast cancer and is associated with poor patient outcome. However, the cellular mechanism by which matriptase mediates breast cancer invasion remains unknown. The present study aimed to determine the role of matriptase in the protein kinase C (PKC)‑mediated metastasis of MCF‑7 human breast cancer cells. Matri...
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#1So Mi Jeon (Dong-a University)
#2Je Sun Lim (Dong-a University)
Last. Jong Ho Lee (Dong-a University)H-Index: 23
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The activation of Wnt signaling has been detected in various types of human cancer and has been shown to be associated with cancer development. In the present study, it was revealed that Wnt signaling induced the expression of phosphofructokinase 1 platelet isoform (PFKP), which has been reported to catalyze a rate‑limiting reaction in glycolysis and is important for the Warburg effect, proliferation, colony formation and cancer cell migration. Moreover, it was demonstrated that Wnt3A induced PF...
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#1Liwei Xu (ZJU: Zhejiang University)H-Index: 3
#2Zeyi Lu (ZJU: Zhejiang University)H-Index: 2
Last. Yuanlei Chen (ZJU: Zhejiang University)H-Index: 3
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Currently, high‑throughput quantitative proteomic and transcriptomic approaches have been widely used for exploring the molecular mechanisms and acquiring biomarkers for cancers. Our study aimed to illuminate the multi-dimensional molecular mechanisms underlying renal cell carcinoma (RCC) via investigating the quantitative global proteome and the profile of phosphorylation. A total of 5,428 proteins and 8,632 phosphorylation sites were quantified in RCC tissues, with 709 proteins and 649 phospho...
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#1Stefania Mantziou (RMIT: RMIT University)H-Index: 4
#2Georgios S. Markopoulos (RMIT: RMIT University)H-Index: 10
Last. Theodore Tzavaras (RMIT: RMIT University)H-Index: 11
view all 7 authors...
Tinzaparin is an anticoagulant and antiangiogenic drug with inhibitory properties against tumor growth. VEGF stimulates angiogenesis, while an association between reactive oxygen species (ROS) and angiogenesis is involved in tumor progression. The present study aimed to investigate the effect of tinzaparin on VL30 retrotransposition‑positive mouse HC11 mammary stem‑like epithelial cells, previously reported to be associated with induced mammosphere/cancer stem cell (CSC) generation and tumorigen...
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#1Zhiwei Wang (Zhengzhou University)H-Index: 5
#2Mingxing Li (Zhengzhou University)H-Index: 5
Last. Bo Liu (Zhengzhou University)
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Dihydroartemisinin (DHA), an artemisinin derivate, has been investigated as a potential antitumor drug in primary liver cancer (PLC). Ferroptosis is a form of iron‑dependent cell death that can be driven by lipid peroxidation inducers. The present study aimed to determine whether and how DHA could promote the death of PLC cells by inducing ferroptosis. In total, four PLC cell lines with different p53 statuses, including Hep3B (p53 null), Huh7 (p53 mutant), PLC/PRF/5 (p53 mutant) and HepG2 (p53 w...
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#1Li-Min Liu (Southern Medical University)H-Index: 2
#2Wenjuan Shi (Southern Medical University)H-Index: 1
Last. Zhihua Liu (Southern Medical University)H-Index: 2
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Bacillus Calmette‑Guerin (BCG) immunotherapy increases macrophage polarization toward M1‑type macrophages. In the present study, to identify the M1/M2 marker genes in the carcinogenesis and progression of cervical cancer, the microarray datasets GSE9750 and GSE7803 were downloaded from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and the University of California Santa Cruz (UCSC) Xena browser. Survival analysis revealed that M1 markers (IL‑12) were involved in anti‑tumour progre...
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#1Dimitra P. Vageli (Yale University)H-Index: 14
#2Sotirios G. Doukas (Yale University)H-Index: 9
Last. Benjamin L. Judson (Yale University)H-Index: 26
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Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been considered a risk factor in the development of hypopharyngeal cancer. Bile acids are frequently present in the gastroesophageal refluxate and their effect has been associated with inflammatory and neoplastic changes in the upper aerodigestive tract. Recent in vitro and in vivo studies have provided direct evidence of the role of acidic bile refluxate in hypopharyngeal carcinogenesis and documented the crucial role o...
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#1Yunyao Deng (Southern Medical University)H-Index: 1
#2Min Yujuan (North Sichuan Medical College)
Last. Xie Zhang
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Colorectal cancer (CRC) is a common malignancy with significant prevalence and mortality rates. Circular RNA FOXO3 (circ‑FOXO3; hsa_circ_0006404) has been reported to be involved in cancer regulation; however, its role in CRC is yet to be fully elucidated. Therefore, the aim of the present study was to investigate the effect of circ‑FOXO3 on CRC progression and identify its underlying mechanism. In the present study, the expression of circ‑FOXO3 was investigated in CRC tissues and cells via reve...
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#1Xiangling Chen (Chengdu Medical College)
#2Fangfang Liu (MUC: Minzu University of China)
Last. Fan Xu (Chengdu Medical College)
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Pancreatic cancer (PC) is a lethal malignancy. Its prevalence rate remains low but continues to grow each year. Among all stages of PC, metastatic PC is defined as late‑stage (stage IV) PC and has an even higher fatality rate. Patients with PC do not have any specific clinical manifestations. Most cases are inoperable at the time‑point of diagnosis. Prognosis is also poor even with curative‑intent surgery. Complications during surgery, postoperative pancreatic fistula and recurrence with metasta...
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Last. Juan Du (Capital Medical University)
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Despite the marked success of molecular targeted therapy in lung cancer in this era of personalized medicine, its efficacy has been limited by the presence of resistance mechanisms. The prognosis of patients with lung cancer remains poor, and there is an unmet need to develop more effective therapies to improve clinical outcomes. The increasing insight into the human immune system has led to breakthroughs in immunotherapy and has prompted research interest in employing immunotherapy to treat lun...
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