Clinical Reviews in Allergy & Immunology
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#2Pedro Muñoz CachoH-Index: 5
Last. Víctor M. Martínez-Taboada (UC: University of Cantabria)H-Index: 38
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The natural history of antiphospholipid antibodies (aPL) carriers is not well-established. The objectives of the present study were (a) to study the probability of developing clinical criteria of antiphospholipid syndrome (APS), (b) to identify potential risk factors for developing thrombosis and/or obstetric complications, (c) to study the association between the antibody profile and development of APS, and (d) to determine the efficacy of primary prophylaxis. We retrospectively analyzed 138 su...
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#1Ankur Kumar Jindal (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 11
#2Avner ReshefH-Index: 25
Last. Hilary LonghurstH-Index: 31
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There are now more than 450 described monogenic germline mutations for inborn errors of immunity that result in the loss of expression, loss of function (LOF), or gain in function (GOF) of the encoded protein. Molecular characterization of these inborn errors of immunity has not only allowed us to characterize on a genetic basis these immune deficiency disorders but has provided a better understanding of the immunobiology of these inborn errors of immunity. More recently, these advances have all...
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#1Anastasios Apostolos (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Maria Drakopoulou (UoA: National and Kapodistrian University of Athens)H-Index: 17
Last. Konstantinos Toutouzas (UoA: National and Kapodistrian University of Athens)H-Index: 34
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Nickel is one of the most common contact allergens worldwide; it is used as the main component of the devices used for atrial septal defects (ASDs) and patent foramen ovale (PFO) closure. Developing nickel hypersensitivity after PFO/ASD occlusion is significantly rarer described in medical literature than typical nickel contact sensitization. The exact pathophysiological mechanism of this “device syndrome” remains unknown, and many question the real incidence or even the existence of this clinic...
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Systemic lupus erythematosus is a complex immunological disease where both environmental factors and genetic predisposition lead to the dysregulation of important immune mechanisms. Eventually, the combination of these factors leads to the production of self-reactive antibodies that can target any organ or tissue of the human body. Autoantibodies can form immune complexes responsible for both the organ damage and the most severe complications. Involvement of the central nervous system defines a ...
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#1Jingjing Chen (Peking Union Medical College)
#2Xu Yao (Peking Union Medical College)
Behcet's syndrome (BS) is a chronic systemic inflammatory vasculitis with a wide range of clinical manifestations including recurrent oral and genital ulcers; cutaneous lesions; and ophthalmic, neurologic, and gastrointestinal involvement. BS has a global distribution but is particularly prevalent in so-called Silk Road populations. Disease onset is usually around the third or fourth decade of life, and the sex ratio is roughly 1:1. Both environmental and genetic factors contribute to the etiolo...
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#2Jeffrey B. Travers (Wright State University)H-Index: 46
Last. Craig Rohan (Wright State University)H-Index: 1
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Sex differences have been well documented within hereditary angioedema (HAE) over the past several decades. Females often experience more frequent and more intense attacks compared to their male counterparts. Additionally, elevated estrogen levels-as seen in pregnancy and use of oral contraceptives-is a widely known trigger for angioedema attacks. In this review article, we will outline how estrogens' downstream effects increase bradykinin, a potent vasodilator and key mediator of HAE. Estrogen-...
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#1Troy Wanandy (Royal Hobart Hospital)H-Index: 5
#2Emily M. Mulcahy (UTAS: University of Tasmania)H-Index: 2
Last. Michael D. Wiese (UniSA: University of South Australia)H-Index: 29
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Hymenoptera venom allergy is characterised by systemic anaphylactic reactions that occur in response to stings from members of the Hymenoptera order. Stinging by social Hymenoptera such as ants, honeybees, and vespids is one of the 3 major causes of anaphylaxis; along with food and drug exposure, it accounts for up to 43% of anaphylaxis cases and 20% of anaphylaxis-related fatalities. Despite their recognition as being of considerable public health significance, stinging ant venoms are relativel...
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#1Anne Lise Ferrara (University of Naples Federico II)H-Index: 6
#2Leonardo Cristinziano (University of Naples Federico II)H-Index: 4
Last. Stefania Loffredo (University of Naples Federico II)H-Index: 22
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Hereditary angioedema (HAE) is a rare genetic disease, characterized by recurrent and unexpected potentially life-threatening mucosal swelling. HAE may be further classified into HAE with C1-inhibitor deficiency (C1-INH-HAE) and HAE with normal C1-INH activity (nlC1-INH-HAE), mostly due to mutations leading to increased vascular permeability. Recent evidence implicates also the innate and adaptive immune responses in several aspects of angioedema pathophysiology. Monocytes/macrophages, granulocy...
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#1Daniel Elieh Ali Komi (Urmia University of Medical Sciences)H-Index: 11
#2Wolfgang M. Kuebler (Charité)H-Index: 49
Mast cells (MCs) are critically involved in microbial defense by releasing antimicrobial peptides (such as cathelicidin LL-37 and defensins) and phagocytosis of microbes. In past years, it has become evident that in addition MCs may eliminate invading pathogens by ejection of web-like structures of DNA strands embedded with proteins known together as extracellular traps (ETs). Upon stimulation of resting MCs with various microorganisms, their products (including superantigens and toxins), or syn...
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