Journal of Lipid Research
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#1Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 86
Abstract null null Triglycerides are carried in the bloodstream as components of very low-density lipoproteins and chylomicrons. These circulating triglycerides are primarily hydrolyzed in muscle and adipose tissue by the enzyme lipoprotein lipase (LPL). The activity of LPL is regulated by numerous mechanisms, including by three members of the angiopoietin-like protein family: ANGPTL3, ANGPTL4, and ANGPTL8. In this review, we discuss the recent literature concerning the role and mechanism of act...
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#1Yujeong Choi (Ewha Womans University)H-Index: 1
#2Eun Goo Lee (SNU: Seoul National University)H-Index: 6
Last. Eun Sook Hwang (Ewha Womans University)H-Index: 22
view all 8 authors...
Testosterone is a hormone essential for male reproductive function. It is produced primarily by Leydig cells in the testicle through activation of steroidogenic acute regulatory protein (StAR) and a series of steroidogenic enzymes, including a cytochrome P450 side-chain cleavage enzyme (CYP11A1), 17α-hydroxylase (CYP17A1), and 3β-hydroxysteroid dehydrogenase (3βHSD). These steroidogenic enzymes are mainly regulated at the transcriptional level and their expression is increased by the nuclear rec...
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#1Anne-Marie Lund Winther (UCPH: University of Copenhagen)H-Index: 13
#2Kristian Kølby Kristensen (Finsen Laboratory)H-Index: 8
Last. Michael Ploug (Finsen Laboratory)H-Index: 61
view all 4 authors...
Abstract null Lipoprotein lipase (LPL) is essential for intravascular lipid metabolism and is of high medical relevance. Since LPL is notoriously unstable, there is an unmet need for a robust expression system producing high quantities of active and pure recombinant human LPL. We showed previously that bovine LPL purified from milk is unstable at body temperature (Tm is 34.8 °C), but in the presence of the endothelial transporter glycosylphosphatidylinositol-anchored high-density lipoprotein–bin...
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#1Henry N. Ginsberg (Columbia University)H-Index: 116
#2Robert S. Rosenson (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 79
Last. Christopher P. Cannon (Brigham and Women's Hospital)H-Index: 172
view all 7 authors...
Accurate assessment of LDL-C levels is important, as they are often used for treatment recommendations. For many years, plasma LDL-C levels were calculated using the Friedewald equation, but there are limitations to this method compared with direct measurement via beta-quantification (BQ). Here we assessed differences between the Friedewald, Martin-Hopkins, and NIH Equation 2 methods of calculating LDL-C and the "gold standard" BQ method using pooled Phase 3 data with alirocumab (a PCSK9 inhibit...
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#1Yiran Liu (Agency for Science, Technology and Research)H-Index: 1
#2David Castaño (Agency for Science, Technology and Research)H-Index: 2
Last. Roshni R. Singaraja (Agency for Science, Technology and Research)H-Index: 51
view all 15 authors...
The myelin sheath, which is wrapped around axons, is a lipid-enriched structure produced by mature oligodendrocytes. Disruption of the myelin sheath is observed in several neurological diseases, such as multiple sclerosis. A crucial component of myelin is sphingomyelin, levels of which can be increased by ABCA8, a member of the ATP-binding cassette transporter family. ABCA8 is highly expressed in the cerebellum, specifically in oligodendroglia. However, whether ABCA8 plays a role in myelination ...
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#1Oleg Kovrov (Umeå University)H-Index: 6
#2Fredrik Landfors (Umeå University)H-Index: 1
Last. Gunilla Olivecrona (Umeå University)H-Index: 62
view all 5 authors...
Abstract null null Lipoprotein lipase (LPL) is a key player in plasma triglyceride metabolism. Consequently, LPL is regulated by several proteins during synthesis, folding, secretion, and transport to its site of action at the luminal side of capillaries, as well as during the catalytic reaction. Some proteins are well known, while others have been identified but are still not fully understood. We set out to study the effects of the natural variations in the plasma levels of all known LPL regula...
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#1Keisuke Kitakaze (Kawasaki Medical School)H-Index: 7
#2Kazuhito Tsuboi (Kawasaki Medical School)H-Index: 30
Last. Yasuo Okamoto (Kawasaki Medical School)H-Index: 33
view all 6 authors...
Abstract null Lysophosphatidic acid (LPA) is a lipid mediator that regulates various processes, including cell migration and cancer progression. Autotaxin (ATX) is a lysophospholipase D-type exoenzyme that produces extracellular LPA. In contrast, glycerophosphodiesterase (GDE) family members GDE4 and GDE7 are intracellular lysophospholipases D that form LPA, depending on Mg2+ and Ca2+, respectively. Since no fluorescent substrate for these GDEs has been reported, in the present study, we examine...
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#1Megan M. Knuth (UNC: University of North Carolina at Chapel Hill)
#2Whitney L. Stutts (NCSU: North Carolina State University)H-Index: 8
Last. Seth W. Kullman (NCSU: North Carolina State University)H-Index: 26
view all 5 authors...
Vitamin D is well known for its traditional role in bone mineral homeostasis; however, recent evidence suggests that vitamin D also plays a significant role in metabolic control. This study served to investigate putative linkages between vitamin D deficiency (VDD) and metabolic disruption of bioactive lipids by mass spectrometry imaging (MSI). Our approach employed infrared-matrix-assisted laser desorption electrospray ionization (IR-MALDESI) MSI for lipid metabolite profiling in 6-month-old zeb...
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#1Harald Köfeler (Medical University of Graz)H-Index: 33
#2Robert Ahrends (University of Vienna)H-Index: 22
Last. Gerhard Liebisch (University Hospital Regensburg)H-Index: 64
view all 9 authors...
In the last two decades, lipidomics has become one of the fastest expanding scientific disciplines in biomedical research. With an increasing number of new research groups to the field, it is even more important to design guidelines for assuring high standards of data quality. The Lipidomics Standards Initiative (LSI) is a community-based endeavor for the coordination of development of these best practice guidelines in lipidomics, and is embedded within the International Lipidomics Society (ILS)...
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#1Rumei Li (UMCG: University Medical Center Groningen)H-Index: 2
#2A. Palmiotti (UMCG: University Medical Center Groningen)H-Index: 2
Last. Jingyuan Fu (UMCG: University Medical Center Groningen)H-Index: 57
view all 13 authors...
Bile acids (BAs) play important roles in lipid homeostasis and BA signaling pathways serve as therapeutic targets for non-alcoholic fatty liver disease (NAFLD). Recently, we generated Cyp2c70-/- mice with a human-like BA composition lacking mouse/rat-specific muricholic acids (MCAs) to accelerate translation from mice to humans. We employed this model to assess the consequences of a human-like BA pool on diet-induced obesity and NAFLD development. Male and female Cyp2c70-/- mice and wild-type (W...
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