Biomedical Optics Express
Papers 4,551
1 page of 456 pages (4,551 results)
#1Jinchao Feng (Beijing University of Technology)H-Index: 8
#2Shudong Jiang (Dartmouth College)H-Index: 37
Last. Keith D. Paulsen (Dartmouth College)H-Index: 100
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Integration of magnetic resonance imaging (MRI) and near-infrared spectral tomography (NIRST) has yielded promising diagnostic performance for breast imaging in the past. This study focused on whether MRI-guided NIRST can quantify hemoglobin concentration using only continuous wave (CW) measurements. Patients were classified into four breast density groups based on their MRIs. Optical scattering properties were assigned based on average values obtained from these density groups, and MRI-guided N...
#1Julia Schottenhamml (FAU: University of Erlangen-Nuremberg)H-Index: 7
#2Tobias Würfl (Siemens)H-Index: 2
Last. Andreas Maier (FAU: University of Erlangen-Nuremberg)H-Index: 39
view all 9 authors...
Glaucoma is among the leading causes of irreversible blindness worldwide. If diagnosed and treated early enough, the disease progression can be stopped or slowed down. Therefore, it would be very valuable to detect early stages of glaucoma, which are mostly asymptomatic, by broad screening. This study examines different computational features that can be automatically deduced from images and their performance on the classification task of differentiating glaucoma patients and healthy controls. D...
#1Meiqi Wu (CU: Cornell University)H-Index: 1
#2Siyang Liu (CU: Cornell University)H-Index: 2
Last. Steven G. Adie (CU: Cornell University)H-Index: 23
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Optical microscopy suffers from multiple scattering (MS), which limits the optical imaging depth into scattering media. We previously demonstrated aberration-diverse optical coherence tomography (AD-OCT) for MS suppression, based on the principle that for datasets acquired with different aberration states of the imaging beam, MS backgrounds become decorrelated while single scattering (SS) signals remain correlated, so that a simple coherent average can be used to enhance the SS signal over the M...
#1Alexander L. Matveyev (RAS: Russian Academy of Sciences)H-Index: 17
#2Lev A. Matveev (RAS: Russian Academy of Sciences)H-Index: 22
Last. Vladimir Y. Zaitsev (RAS: Russian Academy of Sciences)H-Index: 22
view all 6 authors...
We present a computationally highly efficient full-wave spectral model of OCT-scan formation with the following features: allowance of arbitrary phase-amplitude profile of illuminating beams; absence of paraxial approximation; utilization of broadly used approximation of ballistic scattering by discrete scatterers without limitations on their density/location and scattering strength. The model can easily incorporate the wave decay, dispersion, measurement noises with given signal-to-noise ratios...
#1Radim Kolář (BUT: Brno University of Technology)H-Index: 3
#2Jan Odstrcilik (BUT: Brno University of Technology)H-Index: 11
Last. R. P. Tornow (FAU: University of Erlangen-Nuremberg)H-Index: 7
view all 3 authors...
Assessment of retinal blood flow inside the optic nerve head (ONH) and the peripapillary area is an important task in retinal imaging. For this purpose, an experimental binocular video ophthalmoscope that acquires precisely synchronized video sequences of the optic nerve head and peripapillary area from both eyes has been previously developed. It enables to compare specific characteristics of both eyes and efficiently detect the eye asymmetry. In this paper, we describe a novel methodology for t...
#1Evan T. Jelly (Duke University)H-Index: 4
#2Yang Zhao (Duke University)H-Index: 4
Last. Adam Wax (Duke University)H-Index: 56
view all 7 authors...
For many clinical applications, such as dermatology, optical coherence tomography (OCT) suffers from limited penetration depth due primarily to the highly scattering nature of biological tissues. Here, we present a novel implementation of dual-axis optical coherence tomography (DA-OCT) that offers improved depth penetration in skin imaging at 1.3 µm compared to conventional OCT. Several unique aspects of DA-OCT are examined here, including the requirements for scattering properties to realize th...
#1Molly A. May (MUI: Innsbruck Medical University)H-Index: 2
#2Kai K. Kummer (MUI: Innsbruck Medical University)H-Index: 10
Last. Alexander Jesacher (MUI: Innsbruck Medical University)H-Index: 28
view all 7 authors...
The two-photon fluorescence imaging depth has been significantly improved in recent years by compensating for tissue scattering with wavefront correction. However, in most approaches the wavefront corrections are valid only over a small sample region on the order of 1 to 10 µm. In samples where most scattering structures are confined to a single plane, sample conjugate correction geometries can increase the observable field to a few tens of µm. Here, we apply a recently introduced fast convergin...
#1Pablo Ortiz (Duke University)H-Index: 2
#2Mark Draelos (Duke University)H-Index: 7
Last. Joseph A. Izatt (Duke University)H-Index: 90
view all 7 authors...
Optical coherence tomography (OCT) has revolutionized diagnostics in ophthalmology. However, OCT requires a trained operator and patient cooperation to carefully align a scanner with the subject’s eye and orient it in such a way that it images a desired region of interest at the retina. With the goal of automating this process of orienting and aligning the scanner, we developed a robot-mounted OCT scanner that automatically aligned with the pupil while matching its optical axis with the target r...
#1Karina G. Bridger (UR: University of Rochester)
#2Jacob R. Roccabruna (UR: University of Rochester)
Last. Timothy M. Baran (UR: University of Rochester)H-Index: 10
view all 3 authors...
We describe a compact fiber-optic probe (2 mm outside diameter) that utilizes spatially-resolved diffuse reflectance for tissue optical property recovery. Validation was performed in phantoms containing Intralipid 20% as scatterer, and methylene blue (MB), MnTPPS, and/or India ink as absorbers. Over a range of conditions, the reduced scattering coefficient was recovered with a root mean square error (RMSE) of 0.86-2.7 cm-1 (average error = 3.8%). MB concentration was recovered with RMSE = 0.26-0...
#1Guangqian Yang (UESTC: University of Electronic Science and Technology of China)H-Index: 2
Last. Zhao Wang (UESTC: University of Electronic Science and Technology of China)H-Index: 2
view all 9 authors...
Coronary stenting or percutaneous coronary intervention (PCI) is widely used to treat coronary artery disease. Improper deployment of stents may lead to post-PCI complication, in-stent restenosis, stent fracture and stent thrombosis. Intravascular optical coherence tomography (OCT) with micron-scale resolution provides accurate in vivo assessment of stent apposition/malapposition and neointima coverage. However, manual stent analysis is labor intensive and time consuming. Existing automated meth...
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