Journal of General Virology
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#1Emad Mohamed Elgendy (Kyoto Prefectural University of Medicine)H-Index: 7
#2Yasuha Arai (Kyoto Prefectural University of Medicine)H-Index: 9
Last. Yohei Watanabe (Kyoto Prefectural University of Medicine)H-Index: 16
view all 11 authors...
Avian H9N2 influenza viruses in East Asia are genetically diversified and multiple genotypes (A-W) have been established in poultry. Genotype S strains are currently the most prevalent strains, have caused many human infections and pose a public health threat. In this study, human adaptation mutations in the PB2 polymerase in genotype S strains were identified by database screening. Several PB2 double mutations were identified that acted cooperatively to produce higher genotype S virus polymeras...
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#1David Prangishvili (TSU: Tbilisi State University)H-Index: 1
#2Ying Liu (Pasteur Institute)H-Index: 14
Last. Mart Krupovic (Pasteur Institute)H-Index: 60
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Portogloboviridae is a family of viruses with circular, double-stranded DNA genomes of about 20 kbp. Their icosahedral virions have a diameter of 87 nm, and consist of an outer protein shell, an inner lipid layer and a nucleoprotein core wound up into a spherical coil. Portogloboviruses infect hyperthermophilic archaea of the genus Saccharolobus, order Sulfolobales and are presumably nonlytic. Portogloboviruses encode mini-CRISPR arrays which they use to compete against other co-infecting viruse...
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#1Simon N. CoveyH-Index: 18
#2John StanleyH-Index: 72
Last. George P. Lomonossoff (JIC: John Innes Centre)H-Index: 70
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#1Qiu-Yan Zhang (CAS: Chinese Academy of Sciences)H-Index: 12
#2Cheng-Lin Deng (CAS: Chinese Academy of Sciences)H-Index: 11
Last. Han-Qing Ye (CAS: Chinese Academy of Sciences)H-Index: 8
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The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, which is highly pathogenic and classified as a biosafety level 3 (BSL-3) agent, has greatly threatened global health and efficacious antivirals are urgently needed. The high requirement of facilities to manipulate the live virus has limited the development of antiviral study. Here, we constructed a reporter replicon of SARS-CoV-2, which can be handled in a BSL-2 laboratory. The Renilla luciferase activity effectively reflect...
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#1Thrimendra Kaushika Dissanayake (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 2
#2Bingpeng Yan (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 4
Last. Kelvin K. W. To (QMUL: Queen Mary University of London)H-Index: 73
view all 8 authors...
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a bronchial epithelial cell line. Most lipid features were downregulated for both influenza virus and rhinovirus, especially for the sphingomyelin features. Pathway analysis showed that sphingolipid met...
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#1Annika Lundstig (Lund University)H-Index: 5
#2Sharia L McDonald (CDC: Centers for Disease Control and Prevention)
Last. Anna-Lena NilssonH-Index: 3
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Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes patients (n=67) and school children controls (n=292) from Jamtland county in Sweden. NLVA were found i...
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#1Joseph W. Golden (USAMRIID: United States Army Medical Research Institute of Infectious Diseases)H-Index: 15
#2Xiankun Zeng (USAMRIID: United States Army Medical Research Institute of Infectious Diseases)H-Index: 20
Last. Jay W. Hooper (USAMRIID: United States Army Medical Research Institute of Infectious Diseases)H-Index: 39
view all 15 authors...
SARS-CoV-2 is the causative agent of COVID-19 and human infections have resulted in a global health emergency. Small animal models that reproduce key elements of SARS-CoV-2 human infections are needed to rigorously screen candidate drugs to mitigate severe disease and prevent the spread of SARS-CoV-2. We and others have reported that transgenic mice expressing the human angiotensin-converting enzyme 2 (hACE2) viral receptor under the control of the Keratin 18 (K18) promoter develop severe and le...
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#1Larissa J Osterbaan (Utica College)
#2Victoria Hoyle (Cornell University)H-Index: 1
Last. Marc Fuchs (Cornell University)H-Index: 46
view all 7 authors...
The RNA-dependent RNA polymerase (1EPol) is involved in replication of grapevine fanleaf virus (GFLV, Nepovirus, Secoviridae) and causes vein clearing symptoms in Nicotiana benthamiana. Information on protein 1EPol interaction with other viral and host proteins is scarce. To study protein 1EPol biology, three GFLV infectious clones, i.e. GHu (a symptomatic wild-type strain), GHu-1EK802G (an asymptomatic GHu mutant) and F13 (an asymptomatic wild-type strain), were engineered with protein 1EPol fu...
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#1Yin Wang (KSU: Kansas State University)H-Index: 7
#2Elizabeth Porter (KSU: Kansas State University)H-Index: 8
Last. Jianfa Bai (KSU: Kansas State University)H-Index: 28
view all 9 authors...
Rotavirus C (RVC) is associated with acute diarrhoea in both children and young animals. Because of its frequent occurrence, additional sequences have recently been generated. In this study, we sequenced 21 complete genomes from porcine diarrhoea samples and analysed them together with all available reference sequences collected from the GenBank database [National Center for Biotechnology Information (NCBI)]. Based on phylogenetic analysis and genetic distance calculation, the number of each seg...
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#1Petar Knezevic (University of Novi Sad)H-Index: 15
#2Evelien M. Adriaenssens (Norwich Research Park)H-Index: 21
Members of the family Plectroviridae produce particles that are non-enveloped rigid rods (70-280×10-16 nm). The supercoiled, circular, single-stranded DNA genome of about 4.5-8.3 kb, encodes 4-13 proteins. Viruses of this family infect cell wall-less bacteria, adsorbing to the bacterial surface, replicating their DNA by a rolling-circle mechanism or transposition, and releasing progeny from cells by extrusion, without killing the host. This is a summary of the International Committee on Taxonomy...
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