Journal of Pharmacology and Experimental Therapeutics
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#1Brendan J. Canning (JHU: Johns Hopkins University)H-Index: 52
#2Qi Liu (JHU: Johns Hopkins University)H-Index: 3
Last. Jing Liang (Apple)H-Index: 1
view all 8 authors...
Studies performed in healthy smokers have documented a diminished responsiveness to tussive challenges and several lines of experimental evidence implicate nicotine as an antitussive component in both cigarette smoke and the vapors generated by electronic cigarettes. We set out to identify the nicotinic receptor subtype involved in the antitussive actions of nicotine and to further evaluate the potential of nicotinic receptor-selective agonists as cough suppressing therapeutics. We confirmed an ...
#1Yaotian Hu (SDU: Shandong University)H-Index: 2
#2Wenjing ZhouH-Index: 6
Last. Jian WangH-Index: 31
view all 13 authors...
Thiabendazole (TBZ), approved by the U.S. Food and Drug Administration (FDA) for human oral use, elicits a potential anti-cancer activity on cancer cells in vitro and in animal models. Here, we evaluated the efficacy of TBZ in the treatment of human glioblastoma multiforme (GBM). TBZ reduced the viability of GBM cells (P3, U251, LN229, A172, and U118MG) relative to controls in a dose- and time-dependent manner. However, normal human astrocytes (NHA) exhibited a greater IC50 than tumor cells line...
#1Tianxiao Wang (Fudan University)
#2Pengying Zhang (Fudan University)
Last. Qunyi Li (Fudan University)H-Index: 12
view all 10 authors...
Esophageal squamous cell carcinoma (ESCC) is one of the major subtypes of esophageal cancer. More than half of the ESCC patients in the world are in China, and the 5-year survival rate is less than 10%. As a new oral proteasome inhibitor, ixazomib has shown strong therapeutic effect in many solid tumors. In this study, we aimed to investigate the effects of ixazomib on the proliferation inhibition and apoptosis of ESCC cells.We used four human ESCC cell lines, cell viability assay, cell cycle an...
#1Fátima Virgínia Gama Justi (UFC: Universidade Federal do Ceará)
#2Gabriella Araújo Matos (UFC: Universidade Federal do Ceará)H-Index: 2
Last. Reinaldo B. Oriá (UFC: Universidade Federal do Ceará)H-Index: 29
view all 9 authors...
Ruthenium (Ru) compounds, nitric oxide donors in biological systems, have emerged as a promising therapeutical alternative to conventional drugs in anticancer chemotherapy and as a potential neuroprotective agent, with less cytotoxic effects. This minireview summarizes promising studies with ruthenium complexes and their roles in cancer, neuroinflammation, neurovascular, and neurodegenerative diseases. The up-to-date evidence supports that ruthenium-based compounds have beneficial effects agains...
#1Mako Numazaki (Astellas Pharma)H-Index: 2
#2Masaki Abe (Astellas Pharma)H-Index: 7
Last. Yuji Saita (Astellas Pharma)H-Index: 5
view all 11 authors...
Thymic stromal lymphopoietin (TSLP), positioned at the top of the inflammatory cascade, is a key regulator that enhances allergic inflammatory responses by activating T helper type 2 (Th2) cells, Group 2 innate lymphoid cells (ILC2), and myeloid dendritic cells (mDCs) via the TSLP receptor (TSLPR). We evaluated the inhibitory effects of ASP7266, a novel recombinant fully human IgG1 monoclonal antibody against TSLPR, on TSLP signaling and inflammation. The inhibitory effects of ASP7266 and the co...
In mammals, MT1 and MT2 melatonin receptors are high affinity G protein-coupled receptors and are thought to be involved in the integration of the melatonin signaling throughout the brain and periphery. In the present study, we describe a new melatonin binding site, named MTx, with a peculiar pharmacological profile. This site had a low affinity for 2-[125I]-melatonin in saturation assays in hypothalamus and retina (pKD = 9.13 {plus minus} 0.05, Bmax = 1.12 {plus minus} 0.11 fmol/mg protein and ...
#1Ilari Tarvainen (UH: University of Helsinki)H-Index: 4
#2Rebecca Nunn (UH: University of Helsinki)
Last. Virpi Talman (UH: University of Helsinki)H-Index: 15
view all 5 authors...
Colorectal cancer is the third most commonly occurring cancer in men and the second in women. The global burden of colorectal cancer is projected to increase to over 2 million new cases with over 1 million deaths within the next 10 years and there is a great need for new compounds with novel mechanisms of action. Our group has developed PKC modulating isophthalic acid derivatives that induce cytotoxicity towards human cervical and prostate cancer cell lines. In this study, we investigated the ef...
#1Jessica I. Griffith (University of Minnesota)H-Index: 2
#2Minjee Kim (University of Minnesota)H-Index: 6
Last. William F. Elmquist (University of Minnesota)H-Index: 53
view all 10 authors...
Novel combinations of specific opioid agonists like loperamide and oxymorphindole targeting the µ- and δ-opioid receptors, respectively, have shown increased potency with minimized opioid-associated risks. However, whether their interaction is pharmacokinetic or pharmacodynamic in nature has not been determined. This study quantitatively determined whether these drugs have a pharmacokinetic interaction that alters systemic disposition or CNS distribution. We performed IV and oral in vivo pharmac...
#1Saeideh Nozohouri (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 6
#2Yong Zhang (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 1
Last. Thomas J. Abbruscato (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 24
view all 5 authors...
Opioids play crucial roles in the regulation of many important brain functions including pain, memory, and neurogenesis. Activation of opioid receptors is reported to have neuroprotective effects after ischemic reperfusion injury. The objective of this study was to understand the role of biphalin and nociceptin, opioid receptor agonists, on blood-brain barrier (BBB) integrity during ischemic stroke. In this study, we aimed to measure the effect of biphalin and nociceptin on astrocytic glutamate ...
#1Julien C. Dodu (VCU: Virginia Commonwealth University)
#2Rebecca Moncayo (VCU: Virginia Commonwealth University)H-Index: 1
Last. Aron H. Lichtman (VCU: Virginia Commonwealth University)H-Index: 80
view all 9 authors...
Opioid use disorder reflects a major public health crisis of morbidity and mortality where opioid withdrawal often contributes to continued use. However, current medications that treat opioid withdrawal symptoms are limited by their abuse liability or lack of efficacy. Although cannabinoid 1 (CB1) receptor agonists, including Δ9-tetrahydrocannabinol (THC), ameliorate opioid withdrawal in both clinical and pre-clinical studies of opioid dependence, this strategy elicits cannabimimetic side effect...
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