Journal of Cancer Research and Clinical Oncology
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7483
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#1Shaoyang Li (NCU: Nanchang University)
#2Le Yang (NCU: Nanchang University)H-Index: 3
Last. Xiao Wu (NCU: Nanchang University)H-Index: 3
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Accurate prediction of topographical correlation between craniopharyngiomas (CPs) and hypothalamus is important for treatment. This study sought to develop a predicting tool based on preoperative-MRI through radiological–surgical–pathological–outcome analysis. Third ventricle floor (TVF), mammillary bodies and cerebral peduncle were evaluated through preoperative-MRI. An eagle-head-like sign named “eagle sign” was observed. Normal TVF on sagittal-MRI was defined as the baseline. Variants of the ...
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#1Débora Cabral de Carvalho Corrêa (UNIFESP: Federal University of São Paulo)H-Index: 1
#2Francine Tesser-Gamba (UNIFESP: Federal University of São Paulo)H-Index: 4
Last. Silvia Regina Caminada de Toledo (UNIFESP: Federal University of São Paulo)H-Index: 23
view all 9 authors...
Gliomas represent the most frequent central nervous system (CNS) tumors in children and adolescents. However, therapeutic strategies for these patients, based on tumor molecular profile, are still limited compared to the wide range of treatment options for the adult population. We investigated molecular alterations, with a potential prognostic marker and therapeutic target in gliomas of childhood and adolescence using the next-generation sequencing (NGS) strategy. We selected 95 samples with ini...
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#1Aroosha Raja (CUI: COMSATS Institute of Information Technology)H-Index: 1
#2Farhan Haq (CUI: COMSATS Institute of Information Technology)H-Index: 8
Hepatocellular carcinoma (HCC) is a lethal human malignancy with a very low overall and long-term survival rate. Poor prognostic outcomes are predominantly associated with HCC due to a huge landscape of heterogeneity found in the deadliest disease. However, molecular subtyping of HCC has significantly improved the knowledge of the underlying mechanisms that contribute towards the heterogeneity and progression of the disease. In this review, we have extensively summarized the current information ...
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#1Shuxian Niu (PRC: China Medical University (PRC))
#2Wenyan Jiang (PRC: China Medical University (PRC))H-Index: 3
Last. Xiran Jiang (PRC: China Medical University (PRC))H-Index: 2
view all 8 authors...
This study aimed to investigate the efficacy of digital mammography (DM), digital breast tomosynthesis (DBT), diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI separately and combined in the prediction of molecular subtypes of breast cancer. A total of 241 patients were enrolled and underwent breast MD, DBT, DW and DCE scans. Radiomics features were calculated from intra- and peritumoral regions, and selected with least absolute shrinkage and selection operator (LASSO) regression t...
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#1Ya-Nan JinH-Index: 4
#2Huijiao Cao (SYSU: Sun Yat-sen University)H-Index: 2
Last. Liangping XiaH-Index: 9
view all 7 authors...
Adding neoadjuvant chemotherapy (NAC) to concurrent chemoradiotherapy (CCRT) is the main strategy in treatment of children and adolescents with locoregionally advanced nasopharyngeal carcinoma (CA-LANPC). Yet, an optimal number of NAC cycles remains unknown. We aimed to optimize the NAC cycle and potentially contribute to clinical decision making for the individual treatment of CA-LANPC. Utilizing an NPC-specific database through an acknowledged big-data information system at our center, we iden...
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#1Sharath M Bhat (Manipal University)
#2Vaishnavi A Badiger (Manipal University)
Last. Manjunath B. Joshi (Manipal University)H-Index: 19
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The development of blood vessels, referred to as angiogenesis, is an intricate process regulated spatially and temporally through a delicate balance between the qualitative and quantitative expression of pro and anti-angiogenic molecules. As angiogenesis is a prerequisite for solid tumors to grow and metastasize, a variety of tumor angiogenesis models have been formulated to better understand the underlying mechanisms and associated clinical applications. Studies have demonstrated independent me...
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#1Yu-Chi Chen (UM: University of Macau)
#2Wei Shi (UM: University of Macau)
Last. Jin-Jian Lu (UM: University of Macau)H-Index: 38
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CD47, a transmembrane protein, acts as a "do not eat me" signal that is overexpressed in many tumor cell types, thereby forming a signaling axis with its ligand signal regulatory protein alpha (SIRPα) and enabling the tumor cells to escape from macrophage-mediated phagocytosis. Several clinical trials with CD47 targeting agents are underway and have achieved impressive results preliminarily. However, hematotoxicity (particularly anemia) has emerged as the most common side effect that cannot be n...
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Curative intended treatment is challenging in patients with relapsed or refractory acute myeloid leukemia (r/r AML) and associated with a dismal prognosis for long-term survival. Despite novel treatment options, the majority of patients are treated with chemotherapy-based regimens. Although widely used, little data exist on the combination of fludarabine, cytarabine, granulocyte colony stimulating factor (FLAG) and mitoxantrone as salvage strategy for r/r AML. Sixty-six patients receiving Mito-F...
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Although development of immune checkpoint inhibitors has revolutionized the treatment of metastatic melanoma, more than a half of treated patients experience disease progression during therapy. Cases of spontaneous vitiligo-like leukoderma have been described in melanoma patients and have been associated with a favorable outcome. This vitiligo-like leukoderma can also appear in melanoma patients undergoing immune therapies such as immune checkpoint inhibitors. However, no consensus exists about ...
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