Journal of Drug Targeting
IF
5.12
Papers
2,167
Papers 2,132
1 page of 214 pages (2,132 results)
Newest
#1Mishal Pokharel (UMD: University of Massachusetts Dartmouth)
#2Kihan Park (UMD: University of Massachusetts Dartmouth)
Achieving a novel drug delivery system needs site-specificity along with dosage control. Many physical, chemical, mechanical, and biological signals are used for developing these systems, out of which light has been used predominantly in the past decade. Light responsive drug delivery systems have tremendous potential, and their exploration is crucial in developing a precise and controlled delivery system. Spatio-temporal and intensity control of light allows better manipulation of drug delivery...
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#1B. Barczynski (MUL: Medical University of Lublin)H-Index: 8
#2Karolina Frąszczak (MUL: Medical University of Lublin)H-Index: 2
Last. Jan Kotarski (MUL: Medical University of Lublin)H-Index: 18
view all 3 authors...
Insulin resistance and hyperinsulinemia play a key role in type 1 endometrial cancer pathogenesis. Most of these cancers develop on a background of overweight or type 2 diabetes mellitus (T2DM). One of the medications widely used in the treatment of T2DM is biguanide derivative, metformin, which exerts promising anticancer properties principally through activation of adenosine monophosphate kinase (AMPK) and inhibition of mammalian target of rapamycin (mTOR) pathways. Many epidemiological studie...
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#1Xiangtian Deng (NKU: Nankai University)H-Index: 1
#2Qingcheng Song (HMU: Hebei Medical University)H-Index: 1
Last. Yingze Zhang (NKU: Nankai University)H-Index: 1
view all 6 authors...
BACKGROUND Existing therapeutic efficacy of chemotherapy and photodynamic therapy (PDT) is always affected by some resistance factors from tumour environment (TME), such as hypoxia and the antioxidant defense system. PURPOSE This study aims at developing a cascaded intelligent multifunctional nanoplatforms to modulate the TME resistance for synergistically enhanced chemo- and photodynamic therapies. METHODS In this study, we synthesised hollow manganese dioxide nanoparticles (HMDNs) loaded with ...
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#1Yan Du (ZJU: Zhejiang University)H-Index: 3
#2Di Liu (ZJU: Zhejiang University)H-Index: 8
Last. Yong-Zhong Du (ZJU: Zhejiang University)H-Index: 53
view all 3 authors...
Hepatocellular carcinoma (HCC) is one of the most common malignant cancer in the world, which greatly threatens human health. However, the routine treatment strategies for HCC have failed to specifically eradicate the tumorigenic cells, leading to the occurrence of metastasis and recurrence. To improve treatment efficacies, the development of novel effective technologies is urgently required. Recently, nanotechnologies have gained the extensive attention in cancer targeted therapy, which could p...
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#1Yi-Hui Chen (ECUST: East China University of Science and Technology)H-Index: 1
#2Si Li (ECUST: East China University of Science and Technology)
Last. Fu-Jun Wang (SHU: Shanghai University)H-Index: 5
view all 5 authors...
Cell-penetrating peptides (CPPs) have been regarded as potential drug carriers for cancer therapy. However, most well-studied CPPs fail to deliver exogenous drugs efficiently and selectively. In this study, a tumour-targeted CPP with high efficiency derived from heparin-binding domain (HBD) of Midkine (named HMD) was discovered. HMD exhibited higher delivery efficiency than classic CPPs (TAT and R9) and manifested selectivity in tumour cells. Normally, the positive charge is the key factor for t...
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#1Muhammad Suhail (KMU: Kaohsiung Medical University)H-Index: 6
#2Arshad Khan (IUB: Islamia University of Bahawalpur)H-Index: 5
Last. Ashok Kumar Janakiraman (UCSI University)H-Index: 1
view all 8 authors...
Progress in the drug delivery system in the last few decades has led to many advancements for efficient drug delivery. Both micro and nanorobots, are regarded as superior drug delivery systems to d...
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#1Dan Han (CPU: China Pharmaceutical University)
Last. Siliang Wang (NU: Nanjing University)H-Index: 1
view all 9 authors...
Ischaemic stroke remains a leading cause of disability and mortality worldwide and ageing-associated inflammation for the aged patients specifically leads to worse post-stroke blood-brain barrier (BBB) disruption than young subjects. Accordingly, suppression of excessive inflammation can alleviate BBB injury, which provides potential therapeutic treatment for ischaemic stroke of the aged. Prior studies revealed that mesencephalic astrocyte-derived neurotrophic factor (MANF) regulated inflammator...
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The review highlights the safety issues of drug delivery systems based on liposomes. Due to their small sizes (about 80-120 nm, sometimes even smaller), phospholipid nanoparticles interact intensively with living systems during parenteral administration. This interaction significantly affects both their transport role and safety; therefore, special attention is paid to these issues. The review summarizes the data on the basic factors affecting the safety of nanoliposomes: composition, size, surf...
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#1Rahul S. TadeH-Index: 6
#2Mahesh P. MoreH-Index: 10
Last. Pravin O. PatilH-Index: 14
view all 4 authors...
Lung cancer (LC) is heading up as a substantial cause of mortality worldwide. Despite enormous progress in cancer management, LC remains a crucial problem for oncologists due to the lack of early diagnosis and precise treatment. In this context, numerous early diagnosis and treatment approaches for LC at the cellular level have been developed using advanced nanomaterials in the last decades. Amongst this, graphene quantum dots (GQDs) as a novel fluorescent material overwhelmed the horizons of ma...
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#1Ahmet Erdem (KOU: University of Kocaeli)H-Index: 8
#2Reihaneh Haghniaz (UCLA: University of California, Los Angeles)H-Index: 11
Last. Nureddin Ashammakhi (UCLA: University of California, Los Angeles)H-Index: 41
view all 7 authors...
Sustained external supply of oxygen (O2) to engineered tissue constructs is important for their survival in the body while angiogenesis is taking place. In the recent years, the trend towards the fabrication of various O2-generating materials that can provide prolonged and controlled O2 source to the large volume tissue constructs resulted in preventing necrosis associated with the lack of O2 supply. In this review, we explain different methods employed in the fabrication of O2-generating materi...
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