S. Dhivya
SRM University
OsseointegrationAnatomySelf-healing hydrogelsDrug carrierBiomedical engineeringChemistryMaterials scienceRUNX2OsteoblastSwellingBone tissueChitosanMTT assayBone regenerationChemical engineeringTissue engineeringPolymerBone resorptionProtein adsorptionNanofiber
10Publications
9H-index
747Citations
Publications 10
Newest
#1S. Dhivya (SRM University)H-Index: 9
#2A. Keshav Narayan (SRM University)H-Index: 1
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
view all 6 authors...
OBJECTIVES: Treatment of critical-sized bone defects with cells and biomaterials offers an efficient alternative to traditional bone grafts. Chitosan (CS) is a natural biopolymer that acts as a scaffold in bone tissue engineering (BTE). Polyphosphate (PolyP), recently identified as an inorganic polymer, acts as a potential bone morphogenetic material, whereas pigeonite (Pg) is a novel iron-containing ceramic. In this study, we prepared and characterized scaffolds containing CS, calcium polyphosp...
39 CitationsSource
#1K. Balagangadharan (SRM University)H-Index: 10
#2S. Dhivya (SRM University)H-Index: 9
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Bone tissue engineering involves biomaterials, cells and regulatory factors to make biosynthetic bone grafts with efficient mineralization for regeneration of fractured or damaged bones. Out of all the techniques available for scaffold preparation, electrospinning is given priority as it can fabricate nanostructures. Also, electrospun nanofibers possess unique properties such as the high surface area to volume ratio, porosity, stability, permeability and morphological similarity to that of extra...
96 CitationsSource
#1S. Preethi Soundarya (SRM University)H-Index: 3
#2V. Sanjay (SRM University)H-Index: 2
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Skeletal tissue damage caused by trauma, injury, or disease can often result in considerable morbidity and the need for new, more reliable strategies for skeletal regeneration. So, to address the unmet need for bone augmentation, bone tissue engineering and regenerative medicine have evolved in the recent years. Bone tissue engineering harnesses novel scaffolds, stem cells and biological factors that promise enhanced and more reliable bone formation. Increasingly phytochemicals, particularly fla...
28 CitationsSource
#1R. LogithKumar (SRM University)H-Index: 1
#2A. KeshavNarayan (SRM University)H-Index: 1
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Critical-sized bone defects treated with biomaterials offer an efficient alternative to traditional methods involving surgical reconstruction, allografts, and metal implants. Chitosan, a natural biopolymer is widely studied for bone regeneration applications owing to its tunable chemical and biological properties. However, the potential of chitosan to repair bone defects is limited due to its water insolubility, faster in vivo depolymerization, hemo-incompatibility, and weak antimicrobial proper...
263 CitationsSource
#1D. Sathya Seeli (Hindustan University)H-Index: 3
#2S. Dhivya (SRM University)H-Index: 9
Last. Mani Prabaharan (Hindustan University)H-Index: 32
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Abstract Guar gum succinate − sodium alginate (GGS-SA) beads cross-linked with barium ions were prepared and characterized as a pH sensitive carrier for colon-specific drug delivery. The structure of GGS-SA beads was confirmed by FT-IR spectroscopy. Scanning Electron Microscope (SEM) studies revealed that the drug loaded GGS-SA beads prepared using 2:2 (w/v) weight percent of GGS and SA had a diameter about 1.4 mm and roughly spherical in shape. X-ray diffraction (XRD) studies showed that the pe...
47 CitationsSource
#1R. LogithKumarH-Index: 1
#2A. KeshavNarayanH-Index: 1
Last. Nagarajan SelvamuruganH-Index: 59
view all 6 authors...
#1S. DhivyaH-Index: 9
#2Ajita JH-Index: 1
Last. Nagarajan SelvamuruganH-Index: 59
view all 3 authors...
Abstract Conventional grafting techniques for bone regeneration are currently being replaced by tissue engineering approaches of using 3D biomimetic materials. Of these biomaterials, metals have the highest mechanical strength; moreover, they play a major role in accelerating bone formation and promoting bone regeneration. They act as cofactors for enzymes, serving as a structural component of bone forming enzymes and proteins, stimulating angiogenesis, increasing extra-cellular matrix synthesis...
31 CitationsSource
#1R. Sainitya (SRM University)H-Index: 2
#2M. Sriram (SRM University)H-Index: 2
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Scaffold based bone tissue engineering utilizes a variety of biopolymers in different combinations aiming to deliver optimal properties required for bone regeneration. In the current study, we fabricated bio-composite scaffolds containing chitosan (CS), carboxymethylcellulose (CMC) with varied concentrations of mesoporous wollastonite (m-WS) particles by the freeze drying method. The CS/CMC/m-WS scaffolds were characterized by the SEM, EDS and FT-IR studies. Addition of m-WS particles had no eff...
70 CitationsSource
#1S. Dhivya (SRM University)H-Index: 9
#2Sekaran Saravanan (SRM University)H-Index: 31
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Background Bone loss during trauma, surgeries, and tumor resection often results in critical-sized bone defects that need to be filled with substitutionary materials. Complications associated with conventional grafting techniques have led to the development of bioactive tissue-engineered bone scaffolds. The potential application of hydrogels as three-dimensional (3D) matrices in tissue engineering has gained attention in recent years because of the superior sensitivity, injectability, and minima...
119 CitationsSource
#1M. Sriram (SRM University)H-Index: 2
#2R. Sainitya (SRM University)H-Index: 2
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Bone tissue engineering is an alternative strategy to overcome the problems associated with traditional treatments for bone defects. A number of bioactive materials along with new techniques like porous scaffold implantation, gene delivery, 3D organ printing are now-a-days emerging for traditional bone grafts and metal implants. Studying the molecular mechanisms through which these biomaterials induce osteogenesis is an equally hot field. Biomaterials could determine the fate of a cell via micro...
35 CitationsSource