Fábio Aguiar-Alves
Federal Fluminense University
SCCmecInternal medicineGenotypeChemistryMedical microbiologyColonizationMethicillin-resistant Staphylococcus aureusStaphylococcal infectionsClindamycinLeukocidinPanton–Valentine leukocidinSepsisStaphylococcus aureusCarriageBiofilmMedicineMultilocus sequence typingBiologyMicrobiologyAntibiotic resistance
35Publications
8H-index
193Citations
Publications 29
Newest
#1Renata Freire Alves Pereira (Federal Fluminense University)H-Index: 5
#2Lialyz Soares Pereira Andre (Federal Fluminense University)H-Index: 2
Last. Fábio Aguiar-Alves (Federal Fluminense University)H-Index: 8
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Staphylococcus aureus is considered the most common opportunistic pathogen in humans, capable of forming biofilm, increasing the chances of antibiotic resistance and causes several chronic diseases. Biodiversity is a source of inspiration in the search for new agents against these microorganisms. Hitherto, the efficacy of Hypericum sp. extracts as an antibacterial agent has already been demonstrated against Gram-positive and Gram-negative bacteria. In this study, we observed that until 4 µg/mL, ...
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#1Priscilla Gonçalves Lomardo (Federal Fluminense University)H-Index: 1
#2N.T. Cardoso-Marques (Federal Fluminense University)
Last. Priscila Ladeira Casado (Federal Fluminense University)H-Index: 15
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Abstract Aim This study aimed to evaluate the prevalence of S. pneumoniae colonization in three different sites in healthy adults: nasopharynx, oropharynx and gingival sulcus. Methods Two-hundred and sixty five adults, aged 20–60 years, who attended dental clinics in one public university (n = 106) and one military institution (n = 159) were enrolled in this study. Pneumococcal detection was performed by direct culture (DC) and PCR for lytA gene after a broth enrichment step. Capsular types were...
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#1Thamiris Santana Machado (Federal Fluminense University)H-Index: 2
#2Felipe Ramos Pinheiro (Federal Fluminense University)H-Index: 1
Last. Fábio Aguiar-Alves (Federal Fluminense University)H-Index: 8
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Hospitalizations related to Methicillin-resistant Staphylococcus aureus (MRSA) are frequent, increasing mortality and health costs. In this way, this study aimed to compare the genotypic and phenotypic characteristics of MRSA isolates that colonize and infect patients seen at two hospitals in the city of Niteroi-Rio de Janeiro, Brazil. A total of 147 samples collected between March 2013 and December 2015 were phenotyped and genotyped to identify the protein A (SPA) gene, the mec staphylococcal c...
1 CitationsSource
#1Luiz C. S. Pinheiro (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 14
#2Lucas Villas Bôas Hoelz (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 9
Last. Fábio Aguiar-Alves (Federal Fluminense University)H-Index: 8
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Following the appearance of several antimicrobial agents to control the spread of infections, two major challenges have emerged: 1- the occurrence and blowout of multiresistant bacteria and the increase of chronic diseases, and 2- difficult-to-eradicate infections. In this study, we tested five benzoylthiourea derivatives for their ability to inhibit and stop bacterial growth and evaluated the possible influence of 1,2,4-triazolyl-benzoylthiourea derivative 4 on the formation and eradication of ...
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#1Maria de Fátima Nogueira de Freitas Alves (Federal Fluminense University)H-Index: 1
#2Bruno Penna (Federal Fluminense University)H-Index: 12
Last. Fábio Aguiar-Alves (Federal Fluminense University)H-Index: 8
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MRSA infection and colonization have been reported in both companion and food-chain animals, highlighting MRSA as an important veterinary and zoonotic pathogen. Another mec allele, the mecC gene, also confers beta-lactam resistance in Staphylococcus aureus and shows 69% nucleotide identity to mecA. The main aim of this study was to investigate the genotypic and clonal profile of methicillin-resistant S. aureus (MRSA) from cows with mastitis in dairy herds. Thirty-five samples suggestive of bovin...
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#1Egidio Domingos André Neto (Federal Fluminense University)H-Index: 1
#2Jaclyn Guerrero (University of California, Berkeley)H-Index: 1
Last. Fábio Aguiar-Alves (Federal Fluminense University)H-Index: 8
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Abstract Staphylococcus aureus nasal colonization is a major risk factor for infection. Studies have suggested an epidemiologic shift in the methicillin-resistant S. aureus (MRSA) strains that circulate in Brazil. We conducted cross-sectional studies of MRSA carriage among 1) children and adolescents in community daycare centers, 2) an outpatient clinic, and 3) hospitals in a large Brazilian metropolitan setting. There were 1.500 study subjects, 500 from each locale: 768 (51.2%) carried S. aureu...
1 CitationsSource
#1Giorgio Silva-Santana (Federal Fluminense University)H-Index: 1
#2Fábio Aguiar-Alves (Federal Fluminense University)H-Index: 8
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AIMS: Staphylococcus aureus is one of the most common pathogens in hospital environment and community. Panton-Valentine leukocidin (PVL) production is clinically associated with skin abscesses, soft tissues infections, bacteraemia and sepsis. This study aimed to investigate the effects of the presence of genes lukF/S-PV coding for PVL, in histological and haematological features during systemic infection, using a Swiss mice experimental model. METHODS AND RESULTS: Experiments were performed usin...
1 CitationsSource
#1Aline Peçanha Muzy Dias (Federal Fluminense University)H-Index: 1
Last. Fábio Aguiar-Alves (Federal Fluminense University)H-Index: 8
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Context: Nosocomial infections arise from many microorganisms, including Staphylococcus aureus. Aims: The aim of this study is to determine the molecular epidemiology of circulating methicillin-resistant S. aureus (MRSA) clones among patients attending community and health-care facilities in Nova Friburgo, RJ, Brazil. Methods: A total of 1002 nasal swab samples were collected from May 2010 to September 2015. S. aureus isolates were identified through phenotypic tests, submitted to antimicrobial ...
1 CitationsSource
BACKGROUND Resistance to antimicrobial agents is a major public health problem, being Staphylococcus aureus prevalent in infections in hospital and community environments and, admittedly, related to biofilm formation in biotic and abiotic surfaces. Biofilms form a complex and structured community of microorganisms surrounded by an extracellular matrix adhered to each other and to a surface that gives them even more protection and resistance to the action of antimicrobial agents, as well as again...
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#1Stephanie Montechiari Pereira da Silva (Federal Fluminense University)
#2Thayssa da Silva Ferreira Fagundes (Federal Fluminense University)H-Index: 2
Last. Alessandra L. Valverde (Federal Fluminense University)H-Index: 8
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