Mahmoud Elsabahy
Texas A&M University
MicelleBiophysicsNanomedicineNanoparticleNanotechnologyNanocarriersCationic polymerizationChemistryPolymer chemistryMaterials scienceIn vivoCombinatorial chemistryNucleic acidBiocompatibilityPaclitaxelEthylene glycolChitosanDrug deliveryDrugPolymerAmphiphileMedicinePharmacology
Publications 77
#1Yue Song (A&M: Texas A&M University)H-Index: 6
#2Mahmoud Elsabahy (A&M: Texas A&M University)H-Index: 28
Last. Lu Su (A&M: Texas A&M University)H-Index: 13
view all 14 authors...
Platelet-like and cylindrical nanostructures from sugar-based polymers are designed to mimic the aspect ratio of bacteria and achieve uroepithelial cell binding and internalization, thereby improving their potential for local treatment of recurrent urinary tract infections. Polymer nanostructures, derived from amphiphilic block polymers composed of zwitterionic poly(d-glucose carbonate) and semicrystalline poly(l-lactide) segments, were constructed with morphologies that could be tuned to enhanc...
1 CitationsSource
#1Mahmoud Elsabahy (A&M: Texas A&M University)H-Index: 28
#2Yue Song (A&M: Texas A&M University)H-Index: 6
Last. Karen L. Wooley (A&M: Texas A&M University)H-Index: 100
view all 6 authors...
Abstract Zwitterionic polymer nanoparticles of diverse morphologies (spherical, cylindrical, and platelet-like) constructed from biocompatible sugar-based polymers are designed to extend the pharmacological activities of short- and long-acting insulin peptides, thereby providing potential for therapeutic systems capable of reducing the frequency of administration and improving patient compliance. Amphiphilic block copolymers composed of zwitterionic poly( d -glucose carbonate) and semicrystallin...
1 CitationsSource
#1Ola A. Sayed (Al-Azhar University)
#2Sahar B. Hassan (Assiut University)H-Index: 3
Last. Ahmed M. El-Sayed (Assiut University)H-Index: 20
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BACKGROUND Intravenous administration of parenteral nutrition (PN) admixtures containing 4-oil lipid injectable emulsion (ILE) in preterm neonates is usually prohibited because of limited clinical data. The authors evaluated the stability, safety, and efficacy of PN admixtures containing 4-oil ILE, for the first time, in preterm neonates. METHODS A series of PN admixtures were prepared for consecutive administration in preterm neonates over a period of 15 days. Admixture stability was assessed a...
#1Mahmoud Elsabahy (Assiut University)H-Index: 28
#2Karen L. Wooley (A&M: Texas A&M University)H-Index: 100
Last. Kenneth J. Oh (Bio-Rad Laboratories)H-Index: 6
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Abstract A robust data mining algorithm is presented as a critical solution to the challenge of managing intensive data generated from the recently developed multiplexing techniques, which allow simultaneous detection of up to 500 biomarkers in a few microliters of a single sample. Furthermore, detailed methodology is provided for exploiting the new algorithm along with examples for description of the first application as a powerful diagnostic and therapeutic monitoring tool in the management of...
1 CitationsSource
#1Eman Gomaa (Zagazig University)H-Index: 1
#2Heba A. Fathi (Assiut University)H-Index: 3
Last. Mahmoud Elsabahy (Misr University for Science and Technology)H-Index: 28
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Abstract Construction of nanocarriers of different structures and properties have shown great promise as delivery systems for a wide range of drugs to improve therapeutic effects and reduce side effects. Nanostructured lipid carriers (NLCs) have been introduced as a new generation of solid lipid nanoparticles (SLNs) to overcome several of the limitations associated with the SLNs. NLCs consist of a blend of solid and liquid lipids which result in a partially crystallized lipid system that enables...
#1Yasmeena Thabet (FSU: Florida State University)
#2Mahmoud Elsabahy (Misr University for Science and Technology)H-Index: 28
Last. Noura G. Eissa (Zagazig University)H-Index: 1
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Abstract Development of nanocarriers has opened new avenues for the delivery of therapeutics of various pharmacological activities with improved targeting properties and reduced side effects. Niosomes, non-ionic-based vesicles, have drawn much interest in various biomedical applications, owing to their unique characteristics and their ability to encapsulate both hydrophilic and lipophilic cargoes. Niosomes share structural similarity with liposomes while overcoming limitations associated with st...
#1Noura G. Eissa (Zagazig University)H-Index: 1
#2Mahmoud Elsabahy (Assiut University)H-Index: 28
Last. Ayat A. Allam (Assiut University)H-Index: 9
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Abstract Glucagon-like peptide-1 (GLP-1) receptor agonists are being increasingly exploited in clinical practice for management of type 2 diabetes mellitus due to their ability to lower blood glucose levels and reduce off-target effects of current therapeutics. Nanomaterials had viewed myriad breakthroughs in protecting peptides against degradation and carrying therapeutics to targeted sites for maximizing their pharmacological activity and overcoming limitations associated with their applicatio...
2 CitationsSource
#1Mahmoud S. AbdelKarim (Assiut University)H-Index: 1
#2Noura H. Abd Ellah (Assiut University)H-Index: 8
Last. Sara A. Abouelmagd (Assiut University)H-Index: 9
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Abstract Channel-based microfluidics was proven to be a helpful platform for reproducible preparation of nanoparticles (NPs), where controlled mixing of fluids allows homogeneous and tuned process of NPs formation. Nanoprecipitation is a popular method for polymeric NPs formation based on controlled precipitation of a polymer upon mixing of two miscible solvents. Conventionally, flow rate, flow rate ratio and polymer concentration have been utilized to control NPs size and polydispersity. Howeve...
1 CitationsSource
#1Ayat A. Allam (Assiut University)H-Index: 9
#2Mahmoud Elsabahy (Misr University for Science and Technology)H-Index: 28
Last. Nermin E Eleraky (Assiut University)H-Index: 4
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Abstract Blindness and impaired vision are considered as the most troublesome health conditions leading to significant socioeconomic strains. The current study focuses on development of nanoparticulate systems (i.e., niosomes) as drug vehicles to enhance the ocular availability of betaxolol hydrochloride for management of glaucoma. Betaxolol-loaded niosomes were further laden into pH-responsive in situ forming gels to further extend precorneal retention of the drug. The niosomes were evaluated i...
1 CitationsSource
#1Radwa Radwan (Assiut University)H-Index: 1
#2Ayat Abdelkader (Assiut University)H-Index: 3
Last. Mahmoud El-Badry (Assiut University)H-Index: 19
view all 6 authors...
Letrozole (LTZ), an aromatase inhibitor with poor aqueous solubility, is used as the first line treatment for hormonal sensitive breast cancer in postmenopausal women. The purpose of the current study is to develop hyaluronic acid (HA)/chitosan (Cs)-coated poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles for the delivery of LTZ to improve therapeutic efficacy, control release and minimize side effects of LTZ. PLGA nanoparticles were prepared, and the effect of various parameters on particle s...
1 CitationsSource