Mauri A. Kostiainen
Aalto University
Surface modificationDNA origamiBiophysicsDNA nanotechnologyDynamic light scatteringNanoparticleNanotechnologyCationic polymerizationChemistryNanostructurePolymer chemistryMaterials scienceSelf-assemblyDrug deliveryLigninChemical engineeringPolymerDNADendrimerSupramolecular chemistry
142Publications
36H-index
4,145Citations
Publications 142
Newest
#1Qing Liu (Aalto University)H-Index: 9
#2Zhuojun Meng (Aalto University)H-Index: 1
Last. Mauri A. Kostiainen (Aalto University)H-Index: 36
view all 5 authors...
Abstract Heparin is one of the most important anticoagulant agents used in clinical applications. Commercial heparin production includes an isolation from mucosa and an additional enrichment step by cationic resins. However, this process remains time-consuming while heparin is obtained in very low concentrations with the presence of macromolecular impurities, such as proteins. Therefore, an alternative with a fast, efficient and selective heparin-recovery performance is highly desirable. In this...
1 CitationsSource
#1João Pedro Martins (UH: University of Helsinki)H-Index: 11
#2Patrícia Figueiredo (UH: University of Helsinki)H-Index: 14
Last. Jarno Salonen (UTU: University of Turku)H-Index: 70
view all 17 authors...
Abstract null null Oral insulin delivery could change the life of millions of diabetic patients as an effective, safe, easy-to-use, and affordable alternative to insulin injections, known by an inherently thwarted patient compliance. Here, we designed a multistage nanoparticle (NP) system capable of circumventing the biological barriers that lead to poor drug absorption and bioavailability after oral administration. The nanosystem consists of an insulin-loaded porous silicon NP encapsulated into...
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#1Yang Xin (University of Paderborn)H-Index: 5
#2Boxuan Shen (Aalto University)H-Index: 14
Last. Adrian Keller (University of Paderborn)H-Index: 25
view all 7 authors...
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#1Gwendoline Delepierre (University of Fribourg)H-Index: 4
#2Katja Heise (Aalto University)H-Index: 5
Last. Alistair W. T. King (UH: University of Helsinki)H-Index: 23
view all 12 authors...
When cellulose nanocrystals (CNCs) are isolated from cellulose microfibrils, the parallel arrangement of the cellulose chains in the crystalline domains is retained so that all reducing end-groups (REGs) point to one crystallite end. This permits the selective chemical modification of one end of the CNCs. In this study, two reaction pathways are compared to selectively attach atom-transfer radical polymerization (ATRP) initiators to the REGs of CNCs, using reductive amination. This modification ...
1 CitationsSource
#1Sofia Ojasalo (Aalto University)
#2Petteri Piskunen (Aalto University)H-Index: 3
Last. Veikko Linko (Aalto University)H-Index: 25
view all 5 authors...
Viruses are among the most intriguing nanostructures found in nature. Their atomically precise shapes and unique biological properties, especially in protecting and transferring genetic information, have enabled a plethora of biomedical applications. On the other hand, structural DNA nanotechnology has recently emerged as a highly useful tool to create programmable nanoscale structures. They can be extended to user defined devices to exhibit a wide range of static, as well as dynamic functions. ...
1 CitationsSource
#1Asma Rahali (Carthage University)H-Index: 1
#1Asma Rahali (UAM: Autonomous University of Madrid)
Last. Eduardo Anaya-Plaza (Aalto University)H-Index: 8
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Design and synthesis of novel photosensitizer architectures is a key step toward new multifunctional molecular materials. Photoactive Janus-type molecules provide interesting building blocks for such systems by presenting two well-defined chemical functionalities that can be utilized orthogonally. Herein a multifunctional phthalocyanine is reported, bearing a bulky and positively charged moiety that hinders their aggregation while providing the ability to adhere on DNA origami nanostructures via...
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#1Heini Ijäs (Aalto University)H-Index: 4
#2Boxuan Shen (Aalto University)H-Index: 14
Last. Veikko Linko (Aalto University)H-Index: 25
view all 8 authors...
Doxorubicin (DOX) is a common drug in cancer chemotherapy, and its high DNA-binding affinity can be harnessed in preparing DOX-loaded DNA nanostructures for targeted delivery and therapeutics. Although DOX has been widely studied, the existing literature of DOX-loaded DNA-carriers remains limited and incoherent. Here, based on an in-depth spectroscopic analysis, we characterize and optimize the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs). In our experimental...
7 CitationsSource
#1Yang Xin (University of Paderborn)H-Index: 5
#2Boxuan Shen (Aalto University)H-Index: 14
Last. Adrian Keller (University of Paderborn)H-Index: 25
view all 7 authors...
The surface-assisted hierarchical assembly of DNA origami nanostructures is a promising route to fabricate regular nanoscale lattices. Herein, we explore the scalability of this approach and demonstrate the formation of a homogeneous polycrystalline DNA origami lattice at the mica-electrolyte interface over a total surface area of 18.75 cm². The topological analysis of more than 50 individual AFM images recorded at random locations over the sample surface showed only minuscule and random variati...
3 CitationsSource
#1Surachet ImlimthanH-Index: 3
Last. Mirkka SarparantaH-Index: 17
view all 9 authors...
Metastatic melanoma can be difficult to detect until at the advanced state that decreases the survival rate of patients. Several FDA-approved BRAF inhibitors have been used for treatment of metastatic melanoma, but overall therapeutic efficacy has been limited. Lutetium-177 (177 Lu) enables simultaneous tracking of tracer accumulation with single-photon emission computed tomography and radiotherapy. Therefore, the codelivery of 177 Lu alongside chemotherapeutic agents using nanoparticles (NPs) m...
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#1Salla VälimäkiH-Index: 5
#2Qing LiuH-Index: 9
Last. Mauri A. KostiainenH-Index: 36
view all 9 authors...
A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.
2 CitationsSource