Christoph Jan Wruck
RWTH Aachen University
Internal medicineEndocrinologyPathologyMolecular biologyReceptorChemistryImmunologyIn vivoOxidative stressInflammationPlacentaVascular endothelial growth factorPreeclampsiaAngiogenesisCancer researchSignal transductionMedicineTranscription factorBiologyCell biology
131Publications
34H-index
2,481Citations
Publications 132
Newest
#1Weiqiang Liang (RWTH Aachen University)H-Index: 1
#2Johannes GrevenH-Index: 6
Last. Philipp LichteH-Index: 16
view all 10 authors...
ABSTRACT Hemorrhagic shock/resuscitation (HS/R) is closely associated with overwhelming oxidative stress and systemic inflammation. As an effective activator of the nuclear factor-erythroid factor 2 related factor 2 (Nrf2) pathway, sulforaphane (SFN) exerts antioxidant and anti-inflammatory effects. We explored SFN's effects on alveolar macrophages (AMs), systemic inflammation, and pulmonary damage in an isolated murine HS/R model. Male C57/BL6 wild type and transgenic antioxidant response eleme...
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#1Yusuke Kubo (RWTH Aachen University)H-Index: 13
#2Wolf Drescher (RWTH Aachen University)H-Index: 21
Last. Thomas Pufe (RWTH Aachen University)H-Index: 34
view all 11 authors...
Significance Osteonecrosis (ON) is characterized by bone tissue death due to disturbance of the nutrient artery. The detailed process leading to the necrotic changes has not been fully elucidated. Clinically, high-dose corticosteroid therapy is one of the main culprits behind ON of the femoral head (ONFH). Recent Advances: Numerous studies have proposed that such ischemia concerns various intravascular mechanisms. Of all reported risk factors, the involvement of oxidative stress in the irreversi...
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#1Yusuke Kubo (RWTH Aachen University)H-Index: 13
#2H Dick (RWTH Aachen University)
Last. Thomas Pufe (RWTH Aachen University)H-Index: 34
view all 7 authors...
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#1AJ Herrera (RWTH Aachen University)
#2Mersedeh Tohidnezhad (RWTH Aachen University)H-Index: 17
Last. Yusuke Kubo (RWTH Aachen University)H-Index: 13
view all 9 authors...
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#2Christoph Jan WruckH-Index: 34
Last. Tim ClarnerH-Index: 27
view all 3 authors...
#2Christoph Jan WruckH-Index: 34
Last. Tim ClarnerH-Index: 27
view all 3 authors...
Source
#1Mersedeh Tohidnezhad (RWTH Aachen University)H-Index: 17
#2Yusuke Kubo (RWTH Aachen University)H-Index: 13
Last. Thomas Pufe (RWTH Aachen University)H-Index: 34
view all 22 authors...
It was hypothesized that strontium (Sr)-doped β-tricalcium phosphate (TCP)-based scaffolds have a positive effect on the regeneration of large bone defects (LBD). Readouts in our mice models were nuclear factor-kappa beta (NF-κB) activity and vascular endothelial growth factor receptor-2 (VEGFR-2) promoter activity during the healing process. A 2-mm critical-size femoral fracture was performed in transgenic NF-κB- and VEGFR-2-luciferase reporter mice. The fracture was filled with a 3D-printed β-...
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#1Anna Nellessen (RWTH Aachen University)H-Index: 1
#2Stella Nyamoya (University of Rostock)H-Index: 11
Last. Tim Clarner (RWTH Aachen University)H-Index: 27
view all 8 authors...
Oxidative stress is a pathophysiological hallmark of many CNS diseases, among multiple sclerosis (MS). Accordingly, boosting the astrocytic transcription factor nuclear factor E2-related factor 2 (Nrf2) system in an MS mouse model efficiently ameliorates oligodendrocyte loss, neuroinflammation and axonal damage. Moreover, Dimethylfumarate, an efficient activator of Nrf2, has recently been approved as therapeutic option in MS treatment. Here, we use the cuprizone mouse model of MS to induce oxida...
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#1Patricia Klemm (RWTH Aachen University)H-Index: 4
#2Anandhi Rajendiran (RWTH Aachen University)H-Index: 1
Last. Kim Ohl (RWTH Aachen University)H-Index: 16
view all 9 authors...
The transcription factor Nrf2 regulates oxidative stress responses. However, the specific function of Nrf2 in Tregs, the central regulators of immune homeostasis, is unclear. Here, we report an unexpected but important role of Nrf2 in Tregs. Nrf2 expression driven by Foxp3 specific deletion of Keap1 resulted in an autoinflammatory phenotype with enhanced effector T cell activation and immune cell infiltrates in the lung. While early postnatal death of mice with Foxp3 specific deletion of Keap1 w...
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