Jane M Blazeby
University of Bristol
Quality of lifeCancerInternal medicineSurgeryOutcome (game theory)Health careRandomized controlled trialIntensive care medicinePhysical therapyQualitative researchMedical physicsAlternative medicinePsychological interventionMEDLINEQuality of life (healthcare)Medical educationFamily medicineColorectal cancerClinical trialGeneral surgeryMedicine
643Publications
83H-index
18.5kCitations
Publications 631
Newest
#1Marcus JepsonH-Index: 12
#2Michelle J. Lazaroo (UoB: University of Bristol)H-Index: 2
Last. Jane M Blazeby (University Hospitals Bristol NHS Foundation Trust)H-Index: 83
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BACKGROUND Recruitment to surgical randomised controlled trials (RCTs) can be challenging. The Sunflower study is a large-scale multi-centre RCT that seeks to establish the clinical and cost effectiveness of pre-operative imaging versus expectant management in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones. Trials such as Sunflower, with a large recruitment target, rely on teamworking. Recruitment can be optimised b...
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#1Melanie CalvertH-Index: 50
#2Madeleine King (USYD: University of Sydney)H-Index: 65
Last. Antonia V. Bennett (UNC: University of North Carolina at Chapel Hill)H-Index: 24
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Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on the impact of disease and treatment on patients' symptoms, function and quality of life. High-quality PRO data from trials can inform shared decision-making, regulatory and economic analyses and health policy. Recent evidence suggests the PRO content of past trial protocols was often incomplete or unclear, leading to research waste. To address this issue, international, consensus-based, PRO-specific guid...
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#1Madeleine Clout (UoB: University of Bristol)H-Index: 4
#2Jane M Blazeby (UoB: University of Bristol)H-Index: 83
Last. William Hollingworth (UoB: University of Bristol)H-Index: 64
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Introduction null Surgery to remove the gallbladder (laparoscopic cholecystectomy (LC)) is the standard treatment for symptomatic gallbladder disease. One potential complication of gallbladder disease is that gallstones can pass into the common bile duct (CBD) where they may remain dormant, pass spontaneously into the bowel or cause problems such as obstructive jaundice or pancreatitis. Patients requiring LC are assessed preoperatively for their risk of CBD stones using liver function tests and ...
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#1Bilal Alkhaffaf (University of Manchester)H-Index: 13
#2Aleksandra Metryka (Boston Children's Hospital)H-Index: 3
Last. Simon Law (HKU: University of Hong Kong)H-Index: 73
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BACKGROUND Surgery is the primary treatment that can offer potential cure for gastric cancer, but is associated with significant risks. Identifying optimal surgical approaches should be based on comparing outcomes from well designed trials. Currently, trials report different outcomes, making synthesis of evidence difficult. To address this, the aim of this study was to develop a core outcome set (COS)-a standardized group of outcomes important to key international stakeholders-that should be rep...
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#1David J BeardH-Index: 64
#2Michael J. CampbellH-Index: 86
Last. Jonathan PughH-Index: 9
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#1Moira Cruickshank (Aberd.: University of Aberdeen)H-Index: 9
#2Rumana Newlands (Aberd.: University of Aberdeen)H-Index: 8
Last. Katie Gillies (Aberd.: University of Aberdeen)H-Index: 15
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Background null Many completed trials of interventions for uncomplicated gallstone disease are not as helpful as they could be due to lack of standardisation across studies, outcome definition, collection and reporting. This heterogeneity of outcomes across studies hampers useful synthesis of primary studies and ultimately negatively impacts on decision making by all stakeholders. Core outcome sets offer a potential solution to this problem of heterogeneity and concerns over whether the ‘right’ ...
1 CitationsSource
#1Bilal AlkhaffafH-Index: 13
#2Jane M BlazebyH-Index: 83
Last. Simon LawH-Index: 73
view all 23 authors...
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Objectives null COVID-19 presents a risk of infection and transmission for operating theatre teams. Guidelines to protect patients and staff emerged and changed rapidly based on expert opinion and limited evidence. This paper presents the experiences and innovations developed by international surgical teams during the early stages of the pandemic to attempt to mitigate risk. null Design null In-depth, semistructured interviews were audio recorded, transcribed and analysed thematically using meth...
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#1Kerry N L Avery (University Hospitals Bristol NHS Foundation Trust)
#2Nicholas Wilson (UoB: University of Bristol)H-Index: 3
Last. Shelley Potter (UoB: University of Bristol)H-Index: 17
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Objective null To develop a core outcome set (COS), an agreed minimum set of outcomes to measure and report in all studies evaluating the introduction and evaluation of novel surgical techniques. null Summary background data null Agreement on the key outcomes to measure and report for safe and efficient surgical innovation is lacking, hindering transparency and risking patient harm. null Methods null (I) Generation of a list of outcome domains from published innovation-specific literature, polic...
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#2Chris A RogersH-Index: 50
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