Sylvia L. Asa
University Hospitals of Cleveland
Internal medicineEndocrinologyPathologyImmunohistochemistryAdenomaAcromegalyCarcinomaPituitary glandNeuroendocrine tumorsPituitary adenomaThyroid cancerPituitary tumorsPituitary neoplasmThyroid carcinomaCancer researchThyroidHormoneMedicineCorticotropic cellBiologySomatotropic cell
Publications 637
#1Jain Prantesh (Case Western Reserve University)
#2Jennifer A. Dorth (Case Western Reserve University)H-Index: 10
Last. Amr Mohamed (University Hospitals of Cleveland)H-Index: 1
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Most of neuroendocrine neoplasms (NENs) are located in the gastrointestinal tract and lung, and they are rarely found on the upper aero-digestive tract, which limit the current literature about nasopharyngeal NENs. This systemic review will summarize the clinical, pathological features and optimal diagnosis and management of different types of nasopharyngeal NENs (NP NENs). In-addition, we herein report an EBV negative TP53-mutated/ Rb-wild type nasopharyngeal neuroendocrine carcinoma (NEC) in a...
#1C. Christofer Juhlin (KI: Karolinska Institutet)H-Index: 25
#2Sylvia L. Asa (University Hospitals of Cleveland)H-Index: 9
Last. Jan Zedenius (KI: Karolinska Institutet)H-Index: 42
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Rarely, salivary gland tumors such as mucoepidermoid carcinoma, mammary analogue secretory carcinoma and mucinous carcinoma arise as primary tumors from ectopic or metaplastic salivary gland tissue adjacent to or within the thyroid gland. We report for the first time a case of primary salivary acinic cell carcinoma (AcCC) adjacent to the thyroid gland in a 71-year-old female patient with Crohns disease and a previous history of malignant melanoma. Following the development of a nodule adjacent t...
#1Sylvia L. Asa (University Hospitals of Cleveland)H-Index: 114
#2Knarik Arkun (Tufts Medical Center)H-Index: 7
Last. Ozgur Mete (UHN: University Health Network)H-Index: 35
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This morphological and immunohistochemical study demonstrates that tumors currently known as "middle ear adenomas" are truly well-differentiated epithelial neuroendocrine tumors (NETs) composed of cells comparable to normal intestinal L cells, and therefore, these tumors resemble hindgut NETs. These tumors show consistent expression of glucagon, pancreatic polypeptide, PYY, and the transcription factor SATB2, as well as generic neuroendocrine markers and keratins. The same L cell markers are exp...
#1Sylvia L. Asa (University Hospitals of Cleveland)H-Index: 114
#2Shereen Ezzat (UHN: University Health Network)H-Index: 40
An excess of growth hormone (GH) results in accelerated growth and in childhood, the clinical manifestation is gigantism. When GH excess has its onset after epiphyseal fusion at puberty, the overgrowth of soft tissue and bone results in acromegaly. Persistent GH excess in gigantism also causes acromegalic features that become evident in the adult years. The causes of GH excess are primarily lesions in the pituitary, which is the main source of GH. In this review, we provide an update on the clin...
#1Sylvia L. Asa (University Hospitals of Cleveland)H-Index: 114
#2Ozgur Mete (UHN: University Health Network)H-Index: 35
Last. Shereen Ezzat (UHN: University Health Network)H-Index: 40
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The classification of adenohypophysial neoplasms as "pituitary neuroendocrine tumors" (PitNETs) was proposed in 2017 to reflect their characteristics as epithelial neuroendocrine neoplasms with a spectrum of clinical behaviors ranging from small indolent lesions to large, locally invasive, unresectable tumors. Tumor growth and hormone hypersecretion cause significant morbidity and mortality in a subset of patients. The proposal was endorsed by a WHO working group that sought to provide a unified...
1 CitationsSource
#1Baris Boyraz (Harvard University)H-Index: 5
#2Peter M. Sadow (Harvard University)H-Index: 35
Last. Ozgur Mete (Princess Margaret Cancer Centre)H-Index: 35
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Tumors with papillary cribriform and morular architecture were initially considered to be variants of papillary thyroid carcinoma; however, recent observations have challenged this view. In this study, we reviewed the demographical, histopathological, and immunohistochemical features of the largest case series, consisting of 33 tumors. The age at time of pathological diagnosis ranged from 18 to 59 (mean 33) years, and all patients except one were female. Sixteen patients had multifocal and fifte...
#1Luvy Delfin (Case Western Reserve University)
#2Ozgur Mete (UHN: University Health Network)H-Index: 35
Last. Sylvia L. Asa (Case Western Reserve University)H-Index: 114
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Follicular cells (FCs) are thought to be agranular, non-hormone producing stellate cells distributed throughout the adenohypophysis, occasionally arranged around colloid-filled follicles, and thought to be more prominent in the vicinity of necrosis and apoptotic cells. A distinct but similar cell type, the folliculostellate cell (FSC), is a sustentacular cell that is negative for keratins and stains for S100, GFAP and SOX10. While several studies have examined FSCs in pituitary neuroendocrine tu...
Oncocytes are cells that have abundant eosinophilic cytoplasm due to the accumulation of mitochondria; they are also known as oxyphils. In the thyroid they have been called Hurthle cells but this is a misnomer, since Hurthle described C cells; for this reason, we propose the use of "oncocyte" as a scientific term rather than an incorrect eponym. Oncocytic change occurs in nontumorous thyroid disorders, in benign and malignant tumors of thyroid follicular cells, in tumors composed of thyroid C ce...
#1Sylvia L. Asa (University Hospitals of Cleveland)H-Index: 114
Detailed analysis of cytodifferentiation and hormone production has classified pituitary neuroendocrine tumors (PitNETs) in a formal system that reflects the lineage differentiation of nontumorous adenohypophysial cells as well as subtypes of tumors that have predictive value. In addition, tumors composed of cells that lack terminal differentiation are well characterized. To comply with the proposal to create an overarching classification of neuroendocrine neoplasia, these tumors are now called ...
#1Ozgur Mete (University Hospitals of Cleveland)H-Index: 2
#2Sara PakbazH-Index: 5
Last. Sylvia L. AsaH-Index: 114
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Alpha-inhibin expression has been reported in pheochromocytomas and paragangliomas (PPGLs). We analyzed alpha-inhibin immunohistochemistry in 77 PPGLs (37 pheochromocytomas [PCCs] and 40 paragangliomas) and correlated the results with catecholamine profile, tumor size, Ki-67 labeling index, succinate dehydrogenase B subunit and carbonic anhydrase IX (CAIX) staining, and genetic pathogenesis. PPGLs were classified as pseudohypoxic cluster 1 disease with documented VHL mutation or SDHx mutation or...