Alain Colige
University of Liège
Matrix metalloproteinaseInternal medicineEndocrinologyPathologyMolecular biologyChemistryExtracellular matrixAlternative splicingImmunologyIn vivoADAMTSADAMTS2ChitosanPlatelet-rich plasmaTendonAngiogenesisCancer researchBiochemistryProcollagen peptidaseMedicineBiologyCell biology
Publications 203
#1Agnès NoëlH-Index: 92
#2Christine GillesH-Index: 43
Last. Alain ColigeH-Index: 50
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The evolution of cancers is dictated by the intrinsic characteristics of malignant cells, but also by the multiple dynamic and reciprocal interactions that they establish with their tissue and cellular environment. This tumour microenvironment is therefore the subject of an ever-increasing part of cancer researches. These notably shed light on the plasticity of function of these non-malignant cells and on the diversity of their impact on the progression of the disease, both in primary tumours an...
#1Laura Brohée (University of Liège)H-Index: 4
#2Julie Crémer (University of Liège)
Last. Christophe Deroanne (University of Liège)H-Index: 14
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The rewiring of lipid metabolism is a major adaptation observed in cancer, and it is generally associated with the increased aggressiveness of cancer cells. Targeting lipid metabolism is therefore an appealing therapeutic strategy, but it requires a better understanding of the specific roles played by the main enzymes involved in lipid biosynthesis. Lipin-1 is a central regulator of lipid homeostasis, acting either as an enzyme or as a co-regulator of transcription. In spite of its important fun...
A disintegrin and metalloproteinase with thrombospondin type I motif (ADAMTS)2 and ADAMTS14 were originally known for their ability to cleave the aminopropeptides of fibrillar collagens. Previous work using N-terminomic approach (N-TAILS) in vitro led to the identification of new substrates, including some molecules involved in TGF-β signaling. Here, N-TAILS was used to investigate the substrates of these two enzymes in vivo, by comparing the N-terminomes of the skin of wild type mice, mice defi...
#1Guangxia WangH-Index: 4
#2Lars Muhl (KI: Karolinska Institutet)H-Index: 18
Last. Andreas van ImpelH-Index: 12
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Proteolytical processing of the growth factor VEGFC through the concerted activity of CCBE1 and ADAMTS3 is required for lymphatic development to occur. How these factors act together in time and space, and which cell types produce these factors is not understood. Here we assess the function of Adamts3 and the related protease Adamts14 during zebrafish lymphangiogenesis and show both proteins to be able to process Vegfc. Only the simultaneous loss of both protein functions results in lymphatic de...
13 CitationsSource
#1Fida Azar (French Institute of Health and Medical Research)H-Index: 1
#2Kevin Courtet (French Institute of Health and Medical Research)H-Index: 1
Last. Nathalie Théret (French Institute of Health and Medical Research)H-Index: 17
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BACKGROUND & AIMS: Activation of hepatic stellate cells (HSC) is a critical process involved in liver fibrosis. Several miRNAs are implicated in gene regulation during this process but their exact and respective contributions is still incompletely understood. Here we propose an integrative approach of miRNA-regulatory networks to predict new targets. METHODS: miRNA regulatory networks in activated HSCs were build using lists of validated miRNAs and the CyTargetLinker tool. The resulting graphs w...
3 CitationsSource
#1Raphaël Riva (University of Liège)H-Index: 21
#2Urmil Shah (University of Liège)H-Index: 1
Last. Christine Jérôme (University of Liège)H-Index: 72
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In the recent decades, biodegradable and biocompatible polyphosphoesters (PPEs) gain wide attention in the biomedical field as relevant substitutes for conventional aliphatic polyesters. These amorphous materials of low glass transition temperature offer promise for the design of soft scaffolds for tissue engineering. Advantageously, the easy variation of the nature of the lateral pendant groups of PPEs allows the insertion of pendent unsaturations valuable for their further crosslinking. In add...
5 CitationsSource
Background: Some studies focusing on the endovascular repair of abdominal aortic aneurysms (AAA) have demonstrated that cancer is often found in such patients. Retrospective investigations have also indicated that AAA patients have an increased risk of cancer. However, the incidence rate of cancer and survival rate in patients with AAA compared to the population remains unknown. Methods: We conducted a prospective, single center, non-randomized, comparative cohort study including 223 AAA patient...
#1Alain Colige (University of Liège)H-Index: 50
#1Alain Colige (University of Liège)H-Index: 12
: ADAMTS are secreted metalloproteinases implicated in many key biological processes. The 19 different members of this family share an identical domain composition at the level of their amino-terminal portion, whereas the identity and number of the domains forming their carboxy-terminal half are divergent and define distinct ADAMTS subfamilies. Due to their large size, extensive glycosylation, the presence of specific domains, their tendency to form aggregates, their relatively low abundance in ...
2 CitationsSource
#1Alain Colige (University of Liège)H-Index: 50
: ADAMTS constitute a family of 19 secreted metalloproteinases involved in diverse physiopathological conditions. Most of their roles first emerged from analysis of spontaneous human and animal mutations or genetically engineered animals. However, the involved mechanisms and the full repertoire of their functions are still largely unrecognized, in part because they are difficult to produce and purify as recombinant active enzymes. Here we describe protocols, tips, and tricks specifically regardi...
#1Benoit Blomme (University of Liège)H-Index: 2
#2Christophe Deroanne (University of Liège)H-Index: 12
Last. Alain Colige (University of Liège)H-Index: 12
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Abstract The mitral valve is a complex multilayered structure populated by fibroblast-like cells, valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold and are submitted to the mechanical deformations affecting valve at each heartbeat, for an average of 40 million times per year. Myxomatous mitral valve (MMV) is the most frequent heart valve disease characterized by disruption of several valvular structures due to alterations of their ECM preventing the c...
6 CitationsSource