Jun Eguchi
Okayama University
Internal medicineDownregulation and upregulationEndocrinologyMolecular biologyReceptorAdipose tissueChemistryApoptosisInflammationType 2 diabetesInsulin resistanceInsulinDiabetic nephropathyKidneyFibrosisDiabetes mellitusMedicineUrinary systemBiologyCell biology
47Publications
22H-index
1,585Citations
Publications 49
Newest
#1Tomokazu Nunoue (Okayama University)H-Index: 4
#2Satoshi Yamaguchi (Okayama University)H-Index: 4
Last. Jun Wada (Okayama University)H-Index: 63
view all 8 authors...
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#1Noriko Fujiwara (Okayama University)
#2Mayu Watanabe (Okayama University)H-Index: 3
Last. Jun Wada (Okayama University)H-Index: 63
view all 8 authors...
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#1Dongxiao Zhang (Okayama University)H-Index: 1
#2Satoshi Yamaguchi (Okayama University)H-Index: 4
Last. Takeshi Y. Hiyama (Okayama University)H-Index: 15
view all 12 authors...
In obesity and type 2 diabetes, numerous genes are differentially expressed, and microRNAs are involved in transcriptional regulation of target mRNAs, but miRNAs critically involved in the appetite control are not known. Here, we identified upregulation of miR-342-3p and its host gene Evl in brain and adipose tissues in C57BL/6 mice fed with high fat-high sucrose (HFHS) chow by RNA sequencing. Mir342 (-/-) mice fed with HFHS chow were protected from obesity and diabetes. The hypothalamic arcuate...
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#1Koki MiseH-Index: 15
#2Mariko ImamuraH-Index: 1
Last. Jun WadaH-Index: 63
view all 25 authors...
1 CitationsSource
#1Atsuko Nakatsuka (Okayama University)H-Index: 17
#2Satoshi Yamaguchi (Okayama University)H-Index: 4
Last. Jun Wada (Okayama University)H-Index: 63
view all 7 authors...
Proximal tubular cells (PTCs) are crucial for maintaining renal homeostasis, and tubular injuries contribute to progression of diabetic kidney disease (DKD). However, the roles of visceral adipose tissue-derived serine protease inhibitor (vaspin) in the development of DKD is not known. We found vaspin maintains PTCs through ameliorating ER stress, autophagy impairment, and lysosome dysfunction in DKD. Vaspin−/− obese mice showed enlarged and leaky lysosomes in PTCs associated with increased apop...
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#1Tomokazu Nunoue (Okayama University)H-Index: 4
#2Satoshi Yamaguchi (Okayama University)H-Index: 4
Last. Jun Wada (Okayama University)H-Index: 63
view all 8 authors...
The adipose tissue is regarded as an endocrine organ and secretes bioactive adipokines modulating chronic inflammation and oxidative stress in obesity. Gal-9 is secreted out upon cell injuries, interacts with T-cell immunoglobulin-3 (Tim-3) and induces apoptosis in activated Th1 cells. Gal-9 also binds to protein disulfide isomerase (PDI), maintains PDI on surface of T cells, and increases free thiols in the disulfide/thiol cycles. To explore the molecular mechanism of obesity, we investigated G...
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#1Ichiro Nojima (Okayama University)H-Index: 1
#2Shingo Eikawa (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 11
Last. Jun Wada (Okayama University)H-Index: 63
view all 14 authors...
The metabolic changes and dysfunction in CD8 + T cells may be involved in tumor progression and susceptibility to virus infection in type 2 diabetes (T2D). In C57BL/6JJcl mice fed with high fat-high sucrose chow (HFS), multifunctionality of CD8 + splenic and tumor-infiltrating lymphocytes (TILs) was impaired and associated with enhanced tumor growth, which were inhibited by metformin. In CD8 + splenic T cells from the HFS mice, glycolysis/basal respiration ratio was significantly reduced and rev...
4 CitationsSource
#1Akihiro Katayama (Okayama University)H-Index: 12
#2Atsuhito ToneH-Index: 8
Last. Jun Wada (Okayama University)H-Index: 63
view all 9 authors...
Aims/introduction The predictive low glucose management (PLGM) system was introduced in March 2018 in Japan. Although there are some reports demonstrating the benefit of PLGM in preventing hypoglycemia, no data are currently available in Japanese patients with type 1 diabetes mellitus (T1DM). The aim of the present study is to evaluate the effect of PLGM with sensor-augmented pump therapy in the prevention of hypoglycemia in Japanese patients.
1 CitationsSource
#1Tomoyo Mifune-Morioka (Okayama University)
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun WadaH-Index: 63
view all 19 authors...
Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3...
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#1Jun Eguchi (Okayama University)H-Index: 22
#2Kazuya Miyashita (Gunma University)H-Index: 13
Last. Anne P. Beigneux (UCLA: University of California, Los Angeles)H-Index: 45
view all 19 authors...
Background Autoantibodies against glycosylphosphatidylinositol-anchored high-density lipoprotein–binding protein 1 (GPIHBP1) cause chylomicronemia by blocking the ability of GPIHBP1 to bind lipoprotein lipase (LPL) and transport the enzyme to its site of action in the capillary lumen. Objective A patient with multiple sclerosis developed chylomicronemia during interferon (IFN) β1a therapy. The chylomicronemia resolved when the IFN β1a therapy was discontinued. Here, we sought to determine whethe...
6 CitationsSource