Nicholas S. Abend
Children's Hospital of Philadelphia
Retrospective cohort studyIntensive care medicinePediatricsProspective cohort studyCohort studyObservational studyStatus epilepticusEpilepsyPediatric intensive care unitMEDLINENeonatal seizureEeg monitoringSymptomatic seizuresIntensive careCritically illAnesthesiaRefractoryElectroencephalographyAudiologyMedicine
Publications 200
#1Theodore Sheehan (Boston Children's Hospital)
#2Marta Amengual-Gual (UIB: University of the Balearic Islands)H-Index: 5
Last. Jessica L. Carpenter (GW: George Washington University)H-Index: 20
view all 46 authors...
OBJECTIVE This study was undertaken to evaluate benzodiazepine (BZD) administration patterns before transitioning to non-BZD antiseizure medication (ASM) in pediatric patients with refractory convulsive status epilepticus (rSE). METHODS This retrospective multicenter study in the United States and Canada used prospectively collected observational data from children admitted with rSE between 2011 and 2020. Outcome variables were the number of BZDs given before the first non-BZD ASM, and the numbe...
#1Monica E. Lemmon (Duke University)H-Index: 14
#2Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 37
Last. Taeun Chang (GW: George Washington University)H-Index: 30
view all 19 authors...
Abstract null null Purpose null Parents of neonates with seizures are at risk of mental health symptoms due to the impact of illness on family life, prognostic uncertainty, and the emotional toll of hospitalization. A family-centered approach is the preferred model to mitigate these challenges. We aimed to identify strategies to promote family-centered care through an analysis of parent-offered advice to clinicians caring for neonates with seizures. null null null Basic procedures null This pros...
#1Alexis A. Topjian (Children's Hospital of Philadelphia)H-Index: 40
#2Bingqing Zhang (Children's Hospital of Philadelphia)H-Index: 4
Last. Nicholas S. Abend (Children's Hospital of Philadelphia)H-Index: 46
view all 6 authors...
Abstract null null Aims null Assessment of brain injury severity early after cardiac arrest (CA) may guide therapeutic interventions and help clinicians counsel families regarding neurologic prognosis. We aimed to determine whether adding EEG features to predictive models including clinical variables and examination signs increased the accuracy of short-term neurobehavioral outcome prediction. null null null Methods null This was a prospective, observational, single-center study of consecutive i...
1 CitationsSource
#1Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
#2Courtney J. Wusthoff (Stanford University)H-Index: 28
Last. Cameron Thomas (UC: University of Cincinnati)H-Index: 8
view all 16 authors...
OBJECTIVE We aimed to evaluate early-life epilepsy incidence, seizure types, severity, risk factors, and treatments among survivors of acute neonatal seizures. METHODS Neonates with acute symptomatic seizures born 7/2015-3/2018 were prospectively enrolled at nine Neonatal Seizure Registry sites. One-hour EEG was recorded at age three months. Post-neonatal epilepsy and functional development (Warner Initial Developmental Evaluation of Adaptive and Functional Skills - WIDEA-FS) were assessed. Cox ...
#1Vasily A. Vakorin (SFU: Simon Fraser University)H-Index: 16
#2Dragos A. Nita (North York General Hospital)
Last. Cecil D. Hahn (U of T: University of Toronto)H-Index: 27
view all 17 authors...
Abstract Objective We aimed to test the hypothesis that computational features of the first several minutes of EEG recording can be used to estimate the risk for development of acute seizures in comatose critically-ill children. Methods In a prospective cohort of 118 comatose children, we computed features of the first five minutes of artifact-free EEG recording (spectral power, inter-regional synchronization and cross-frequency coupling) and tested if these features could help identify the 25 c...
#1Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 37
#2Janet S. Soul (Boston Children's Hospital)H-Index: 37
Last. Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
view all 17 authors...
Importance Antiseizure medication (ASM) treatment duration for acute symptomatic neonatal seizures is variable. A randomized clinical trial of phenobarbital compared with placebo after resolution of acute symptomatic seizures closed early owing to low enrollment. Objective To assess whether ASM discontinuation after resolution of acute symptomatic neonatal seizures and before hospital discharge is associated with functional neurodevelopment or risk of epilepsy at age 24 months. Design, Setting, ...
4 CitationsSource
Abstract Objective Evaluate the influence of weekends and holidays on time to treatment of pediatric refractory convulsive status epilepticus. Methods We performed a retrospective analysis of prospectively collected observational data from June 2011 to March 2020 of pediatric patients (1 month-21 years) with refractory status epilepticus, defined as convulsive seizures that continued after administration of at least two anti-seizure medications (ASMs), including at least one non-benzodiazepine A...
OBJECTIVES To characterize the pediatric super-refractory status epilepticus population by describing treatment variability in super-refractory status epilepticus patients and comparing relevant clinical characteristics, including outcomes, between super-refractory status epilepticus, and nonsuper-refractory status epilepticus patients. DESIGN Retrospective cohort study with prospectively collected data between June 2011 and January 2019. SETTING Seventeen academic hospitals in the United States...
#1Courtney J. Wusthoff (Stanford University)H-Index: 28
#2Vandana Sundaram (Stanford University)H-Index: 25
Last. Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
view all 15 authors...
OBJECTIVE To determine whether screening continuous EEG monitoring (cEEG) is associated with greater odds of treatment success for neonatal seizures. METHODS We included term neonates with acute symptomatic seizures enrolled in the Neonatal Seizure Registry (NSR), a prospective, multicenter cohort of neonates with seizures. We compared two cEEG approaches: (1) Screening cEEG, initiated for indications of encephalopathy or paralysis without suspected clinical seizures, and (2) Confirmatory cEEG, ...
#20Nicholas S. Abend (Children's Hospital of Philadelphia)H-Index: 46
#21Ingo Helbig (Children's Hospital of Philadelphia)H-Index: 49
OBJECTIVE Improvement in epilepsy care requires standardized methods to assess disease severity. We report the results of implementing common data elements (CDEs) to document epilepsy history data in the electronic medical record (EMR) after 12 months of clinical use in outpatient encounters. METHODS Data regarding seizure frequency were collected during routine clinical encounters using a CDE-based form within our EMR. We extracted CDE data from the EMR and developed measurements for seizure se...