Patrick Pirrotte
Translational Genomics Research Institute
ProteomeCancerInternal medicineOncologyMolecular biologyChromatin remodelingKinaseChemistryImmunologyOvarySmall-cell carcinomaOvarian cancerPopulationRNA-binding proteinNeddylationProteomicsCancer researchRNA splicingShotgun proteomicsComputational biologyImmunoprecipitationMedicineSMARCA4ChromatinBiologyCell biology
Publications 54
#1Corina Lesseur (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 22
#2Khyatiben V. Pathak (TGen: Translational Genomics Research Institute)H-Index: 3
Last. Shanna H. Swan (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 60
view all 11 authors...
Human exposure to glyphosate-based herbicides (GBH) is increasing rapidly worldwide. Most existing studies on health effects of glyphosate have focused on occupational settings and cancer outcomes and few have examined this common exposure in relation to the health of pregnant women and newborns in the general population. We investigated associations between prenatal glyphosate exposure and length of gestation in The Infant Development and the Environment Study (TIDES), a multi-center US pregnan...
1 CitationsSource
#1Daniel LiefwalkerH-Index: 2
Last. Adriane Mosley (Stanford University)H-Index: 9
view all 7 authors...
#1Nanyun TangH-Index: 3
Last. Michael E. BerensH-Index: 72
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#9Emily S. Barrett (RU: Rutgers University)H-Index: 27
Abstract Human exposure to glyphosate has become ubiquitous because of its increasing agricultural use. Recent studies suggest endocrine disrupting effects of glyphosate. Specifically, in our work in rodents, low-dose early-life exposure to Roundup® (glyphosate-based herbicide) lengthened anogenital distance (AGD) in male and female offspring. AGD is a marker of the prenatal hormone milieu in rodents and humans. The relationship between glyphosate exposure and AGD has not been studied in humans....
2 CitationsSource
#1Devasier Bennet (UA: University of Arizona)H-Index: 12
#2Yasaman Khorsandian (UA: University of Arizona)
Last. Frederic Zenhausern (TGen: Translational Genomics Research Institute)H-Index: 27
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Several clinical examinations have shown the essential impact of monitoring (de)hydration (fluid and electrolyte imbalance) in cancer patients. There are multiple risk factors associated with (de)hydration, including aging, excessive or lack of fluid consumption in sports, alcohol consumption, hot weather, diabetes insipidus, vomiting, diarrhea, cancer, radiation, chemotherapy, and use of diuretics. Fluid and electrolyte imbalance mainly involves alterations in the levels of sodium, potassium, c...
#1Rebecca F. Halperin (TGen: Translational Genomics Research Institute)H-Index: 15
#2Apurva Hegde (TGen: Translational Genomics Research Institute)H-Index: 2
Last. Patrick Pirrotte (TGen: Translational Genomics Research Institute)H-Index: 8
view all 13 authors...
The robust detection of disease-associated splice events from RNAseq data is challenging due to the potential confounding effect of gene expression levels and the often limited number of patients with relevant RNAseq data. Here we present a novel statistical approach to splicing outlier detection and differential splicing analysis. Our approach tests for differences in the percentages of sequence reads representing local splice events. We describe a software package called Bisbee which can predi...
#1Lucas Vu (Barrow Neurological Institute)H-Index: 1
#2Asmita Ghosh (UdeM: Université de Montréal)H-Index: 1
Last. Christine Vande Velde (UdeM: Université de Montréal)H-Index: 29
view all 11 authors...
Cytoplasmic stress granules (SGs) are dynamic foci containing translationally arrested mRNA and RNA-binding proteins (RBPs) that form in response to a variety of cellular stressors. It has been debated that SGs may evolve into cytoplasmic inclusions observed in many neurodegenerative diseases. Recent studies have examined the SG proteome by interrogating the interactome of G3BP1. However, it is widely accepted that multiple baits are required to capture the full SG proteome. To gain further insi...
2 CitationsSource
#1David Carpentieri (Boston Children's Hospital)H-Index: 10
#2Amber Colvard (Boston Children's Hospital)
Last. T.A. Sivakumaran (Boston Children's Hospital)
view all 8 authors...
Dry blood spots (DBS) offer many advantages over other blood banking protocols due to the reduction of time and equipment needed for collection and the ease of processing, storage, and shipment. In...