Stephen J. Pandol
Veterans Health Administration
CancerInternal medicineEndocrinologyOncologyMolecular biologyHepatic stellate cellChemistryApoptosisPancreatitisAcute pancreatitisPancreatic diseasePancreasPancreatic cancerAcinar cellCancer researchBiochemistryMedicineBiologyGastroenterologyCell biology
Publications 485
#1Stephen J. Pandol (Cedars-Sinai Medical Center)H-Index: 74
#2Chris E. Forsmark (UF: University of Florida)H-Index: 49
PURPOSE OF REVIEW To answer several important clinical questions, the Consortium for the study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) research consortium has established several ongoing clinical cohort studies focused on pancreatitis in adults and children, pancreatic cancer, and diabetes associated with pancreatic disease. These will provide a unique resource for clinical and basic science research into these hard-to-treat diseases. RECENT FINDINGS The cause, natural h...
#1Murli Manohar (Stanford University)H-Index: 15
#2Elaina K. Jones (Stanford University)H-Index: 1
Last. Vishal Sharma (Stanford University)H-Index: 4
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Abstract null Background and Aims null Acute pancreatitis (AP) is an inflammatory disease with mild to severe course that is associated with local and systemic complications and significant mortality. Uncovering inflammatory pathways that lead to progression and recovery will inform ways to monitor and/or develop effective therapies. null Methods null We performed single-cell mass cytometry (CyTOF) analysis to identify pancreatic and systemic inflammatory signals during mild (referred as AP), se...
#1Olga A. Mareninova (UCLA: University of California, Los Angeles)H-Index: 20
#2Eszter T. Vegh (UCLA: University of California, Los Angeles)H-Index: 3
Last. Samuel W. French (UCLA Medical Center)H-Index: 95
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Disordered lysosomal/autophagy pathways initiate and drive pancreatitis, but the underlying mechanisms and links to disease pathology are poorly understood. Here, we show that mannose-6-phosphate (M6P) pathway of hydrolase delivery to lysosomes critically regulates pancreatic acinar cell cholesterol metabolism. Ablation of the Gnptab gene coding for a key enzyme in M6P pathway disrupted acinar cell cholesterol turnover, causing accumulation of non-esterified cholesterol in lysosomes/autolysosome...
1 CitationsSource
#1Daniel LewH-Index: 5
Last. Srinivas GaddamH-Index: 29
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#1Dana K. AndersenH-Index: 21
#2Suresh T. ChariH-Index: 103
Last. Stephen J. PandolH-Index: 74
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#1Christie Y. Jeon (Veterans Health Administration)H-Index: 26
#2Georgios I. Papachristou (OSU: Ohio State University)H-Index: 49
Last. Dhiraj Yadav (University of Pittsburgh)H-Index: 52
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Abstract null null Background/Objectives null Alcohol is the most common etiology of recurrent acute pancreatitis and chronic pancreatitis. The extent and timing of drinking that increases the transient risk of acute pancreatitis is yet unknown. null null null Methods null We designed a case-crossover study to determine the effective hazard period of drinking in relation to episodes of pancreatitis. We aim to evaluate the dose-response relationship between excess drinking and pancreatitis compar...
#1Muhammad Aziz (UT: University of Toledo)H-Index: 13
#2Zohaib Ahmed (UT: University of Toledo)
Last. Stephen J. Pandol (Cedars-Sinai Medical Center)H-Index: 74
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Abstract null null Introduction null Recent studies have evaluated and compared the efficacy of normal saline (NS) and lactated Ringer's (LR) in reducing the severity of acute pancreatitis (AP) and improving outcomes such as length of stay, the occurrence of the systemic inflammatory response syndrome (SIRS), ICU admission and mortality. We performed an updated systematic review and meta-analysis of the available studies to assess the impact of these fluids on outcomes secondary to AP. null null...
#2Chenyu Sun (St. Joseph Hospital)
#2Chenyu Sun (St. Joseph Hospital)H-Index: 7