Olga A. Dontsova
Russian Academy of Sciences
GeneMessenger RNATelomerase reverse transcriptaseTranslation (biology)Molecular biologyTransfer RNATelomereChemistryProtein biosynthesis23S ribosomal RNAGeneticsEscherichia coliDNABiochemistryRNARibosomal RNABiologyRibosomeTelomeraseCell biology
292Publications
34H-index
3,495Citations
Publications 226
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#1Yan A. Ivanenkov (Unitary enterprise)H-Index: 22
#2Kseniya Yu. Filyaeva (RAS: Russian Academy of Sciences)
Last. Olga A. Dontsova (MSU: Moscow State University)H-Index: 34
view all 17 authors...
Abstract The antibacterial properties of close noscapine analogs have not been previously reported. We used our pDualrep2 double-reporter High Throughput Screening (HTS) platform to identify a series of noscapine derivatives with promising antibacterial activity. The platform is based on RPF (SOS-response/DNA damage) and Katushka2S (inhibition of translation) proteins and simultaneously provides information on antibacterial activity and the mechanism of action of small-molecule compounds against...
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#1Aleksei Machulkin (MSU: Moscow State University)H-Index: 1
#2Radik R. Shafikov (MSU: Moscow State University)H-Index: 2
Last. Alexander G. Majouga (MSU: Moscow State University)H-Index: 22
view all 28 authors...
Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is a suitable target for specific delivery of antitumor drugs and diagnostic agents due to its overexpression in prostate cancer cells. In the current work, we describe the design, synthesis, and biological evaluation of novel low-molecular PSMA ligands and conjugates with fluorescent dyes FAM-5, SulfoCy5, and SulfoCy7. In vitro evaluation of synthesized PSMA ligands on the activity of PSMA shows that...
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#1Ting Wang (Peking Union Medical College)H-Index: 3
#2Fei-Na Li (Peking Union Medical College)H-Index: 7
Last. Cheng-Hang Sun (Peking Union Medical College)H-Index: 13
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Abstract Three hundred and twenty endophytic actinobacterial strains were isolated and identified from psammophytes collected in Taklamakan Desert. Among them, three strains already had been identified as new species of two genera and sixteen isolates showed relatively low 16S rRNA similarities (
3 CitationsSource
#1Shao-Wei LiuH-Index: 9
#2Ting WangH-Index: 3
Last. Cheng-Hang SunH-Index: 13
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Taklamakan desert is known as the largest dunefield in China and as the second largest shifting sand desert in the world. Although with long history and glorious culture, the Taklamakan desert remains largely unexplored and numerous microorganisms have not been harvested in culture or taxonomically identified yet. The main objective of this study is to explore the diversity, novelty, and pharmacological potential of the cultivable actinomycetes from soil samples at various sites along the Alar-H...
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#1G. N. SinginaH-Index: 1
#2Petr V. Sergiev (MSU: Moscow State University)H-Index: 28
Last. N. ZinovievaH-Index: 3
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Somatic Cell Nuclear Transfer (SCNT) technique was used to produce the first viable cloned cattle offspring in Russia. Whole-genome SNP genotyping confirmed that the cloned calf was identical to the fibroblast cell line that was used for SCNT. CRISPR/Cas9 approach was subsequently used to knock out genes for beta-lactoglobulin gene (PAEP) and the beta-lactoglobulin-like protein gene (LOC100848610) in the fibroblast cells. Gene editing (GE) efficiency was 4.4% for each of these genes. We successf...
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#1Dmitry A. Skvortsov (MSU: Moscow State University)H-Index: 11
#2Sophia K. Emashova (MSU: Moscow State University)
Last. Olga A. Dontsova (MSU: Moscow State University)H-Index: 34
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Delocalized lipophilic cations (DLCs) are known as mitochondria-addressed molecules. Mitochondria targeting may provide opportunities for tumor detection. DLCs may have antioxidant or anticancer properties. In this study, we focused on the toxicity and localization of 2-[(E)-2-(5-fluoro-2-methyl-1H-indol-3-yl)ethenyl]-1,6-dimethylpyridin-1-ium iodide (62E2), which has recently been found as a novel cytotoxic fluorescent compound. The excitation maximum of 62E2 is 452 ± 10 nm and its emission max...
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#1Dmitrii I. Shiriaev (MSU: Moscow State University)H-Index: 4
#2Alina A. Sofronova (MSU: Moscow State University)H-Index: 6
Last. Olga A. Dontsova (MSU: Moscow State University)H-Index: 34
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Bacterial type II topoisomerases, DNA gyrase and topoisomerase IV, are targets of many antibiotics including fluoroquinolones (FQs). Unfortunately, a number of bacterial species easily acquire resistance to FQs by mutations in either DNA gyrase or topoisomerase IV genes. The emergence of resistant pathogenic strains is a global problem in healthcare, therefore, identifying alternative pathways to thwart their persistence is the current frontier in drug discovery. An attractive class of compounds...
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#1Elena Maksimova (Petersburg Nuclear Physics Institute)H-Index: 2
#2Daria S. Vinogradova (Petersburg Nuclear Physics Institute)H-Index: 2
Last. Andrey L. Konevega (Petersburg Nuclear Physics Institute)H-Index: 21
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Amicoumacin A (Ami) halts bacterial growth by inhibiting the ribosome during translation. The Ami binding site locates in the vicinity of the E-site codon of mRNA. However, Ami does not clash with mRNA, rather stabilizes it, which is relatively unusual and implies a unique way of translation inhibition. In this work, we performed a kinetic and thermodynamic investigation of Ami influence on the main steps of polypeptide synthesis. We show that Ami reduces the rate of the functional canonical 70S...
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#1Marina A. Kalinina (Skolkovo Institute of Science and Technology)H-Index: 3
#2Dmitry A. Skvortsov (MSU: Moscow State University)H-Index: 11
Last. Dmitri D. Pervouchine (Skolkovo Institute of Science and Technology)H-Index: 19
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The mammalian Ate1 gene encodes an arginyl transferase enzyme with tumor suppressor function that depends on the inclusion of one of the two mutually exclusive exons (MXE), exons 7a and 7b. We report that the molecular mechanism underlying MXE splicing in Ate1 involves five conserved regulatory intronic elements R1-R5, of which R1 and R4 compete for base pairing with R3, while R2 and R5 form an ultra-long-range RNA structure spanning 30 Kb. In minigenes, single and double mutations that disrupt ...
2 CitationsSource