Satomi Adegawa
Japan Society for the Promotion of Science
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#1Satomi Adegawa (Japan Society for the Promotion of Science)
#2Naomi Yamaguchi (TUAT: Tokyo University of Agriculture and Technology)
Last. Ryoichi Sato (TUAT: Tokyo University of Agriculture and Technology)H-Index: 29
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Little information is available regarding the region of Cry toxins involved in binding to their major receptors, the ATP-binding cassette (ABC) transporters. We analyzed which Cry1Aa amino acid residues contribute to binding to Bombyx mori ABC transporter C2 (BmABCC2). Several two oxidized double-cysteine substitution mutant toxins were made. In these, two amino acids at distant positions on toxin loop α8 and loop 2 or loop 2 and loop 3 were substituted with cysteine residues and crosslinked. Th...
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