Hans C. Helms
Lundbeck
1Publications
0Citations
Publications 1
Newest
#1Andrea E. Tóth (Lundbeck)H-Index: 12
#2Hans C. Helms (Lundbeck)
Last. Morten Nielsen (Lundbeck)H-Index: 42
view all 16 authors...
Brain homeostasis depends on the existence of the blood-brain barrier (BBB). Despite decades of research, the factors and signalling pathways for modulating and maintaining BBB integrity are not fully elucidated. Here, we characterise the expression and function of the multifunctional receptor, sortilin, in the cells of the BBB, in vivo and in vitro. We show that sortilin acts as an important regulatory protein of the BBB's tightness. In rats lacking sortilin, the BBB was leaky, which correlated...
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