Shangjin Li
Novo Nordisk
ImmunologyImmunotherapyCytokineAutoimmune diseaseImmunosuppressionType 1 diabetesDiabetes mellitusMedicineInterleukinImmune system
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#1Philippe P. Pagni (Novo Nordisk)H-Index: 4
#2Chaplin Jay (Novo Nordisk)
Last. Shangjin Li (Novo Nordisk)
view all 16 authors...
Type 1 diabetes is an autoimmune disease in which insulin-secreting β-cells are destroyed, leading to a life-long dependency on exogenous insulin. There are no approved disease-modifying therapies available, and future immunotherapies would need to avoid generalized immune suppression. We developed a novel plasmid expressing preproinsulin2 and a combination of immune-modulatory cytokines (transforming growth factor-beta-1, interleukin [IL] 10 and IL-2) capable of near-complete prevention of auto...
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