Annika Schulz
Internal medicineEndocrinologyVascular endothelial growth factorPreeclampsiaKidney diseaseDiabetic nephropathyKidneyKidney transplantationEndothelial dysfunctionTyrosine kinaseMedicine
1Publications
0Citations
Publications 1
Newest
Soluble Fms-like tyrosine kinase (sFlt-1/sVEGFR1) is a natural occurring antagonist of vascular endothelial growth factor (VEGF). Despite being a secreted, soluble protein lacking cytoplasmic and transmembrane domains, sFlt-1 can act locally and be protective against excessive microenvironmental VEGF concentration, or exert autocrine functions independently of VEGF. Circulating sFlt-1 may indiscriminately affect endothelial function and the microvasculature on distant target organs. The clinical...
Source